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Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Jakszyn, Paula ; Bingham, Sheila ; Pera, Guillem ; Agudo, Antonio ; Luben, Robert ; Welch, Ailsa ; Boeing, Heiner ; del Giudice, Giuseppe ; Palli, Domenico and Saieva, Calogero , et al. (2006) In Carcinogenesis 27(7). p.1497-1501
Abstract
The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was < 1 mu... (More)
The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was < 1 mu g on average compared with 93 mu g on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 mu g/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk. (Less)
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Carcinogenesis
volume
27
issue
7
pages
1497 - 1501
publisher
Oxford University Press
external identifiers
  • pmid:16571648
  • wos:000238906200024
  • scopus:33745596410
ISSN
0143-3334
DOI
10.1093/carcin/bgl019
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English
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a6b33902-537c-4452-9edc-a2ba83c17134 (old id 402292)
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2016-04-01 11:45:11
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@article{a6b33902-537c-4452-9edc-a2ba83c17134,
  abstract     = {The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was &lt; 1 mu g on average compared with 93 mu g on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7-1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14-1.78 for an increase of 40 mu g/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69-1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P &lt; 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.},
  author       = {Jakszyn, Paula and Bingham, Sheila and Pera, Guillem and Agudo, Antonio and Luben, Robert and Welch, Ailsa and Boeing, Heiner and del Giudice, Giuseppe and Palli, Domenico and Saieva, Calogero and Krogh, Vittorio and Sacerdote, Carlotta and Tumino, Rosario and Panico, Salvatore and Berglund, Göran and Simán, Henrik and Hallmans, Goran and Sanchez, Maria Jose and Larranaga, Nerea and Barricarte, Aurelio and Chirlaque, Maria Dolores and Quiros, Jose R. and Key, Timothy J. and Allen, Naomi and Lund, Eiliv and Carneiro, Fatima and Linseisen, Jakob and Nagel, Gabriele and Overvad, Kim and Tjonneland, Anne and Olsen, Anja and Bueno-de-Mesquita, H. Bas and Ocke, Marga O. and Peeters, Petra H. M. and Numans, Mattijs E. and Clavel-Chapelon, Francoise and Trichopoulou, Antonia and Fenger, Claus and Stenling, Roger and Ferrari, Pietro and Jenab, Mazda and Norat, Teresa and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {0143-3334},
  language     = {eng},
  number       = {7},
  pages        = {1497--1501},
  publisher    = {Oxford University Press},
  series       = {Carcinogenesis},
  title        = {Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study},
  url          = {http://dx.doi.org/10.1093/carcin/bgl019},
  doi          = {10.1093/carcin/bgl019},
  volume       = {27},
  year         = {2006},
}