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Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age

Høyer, Birgit Bjerre; Bonde, Jens Peter; Tøttenborg, Sandra Søgaard; Ramlau-Hansen, Cecilia Høst; Lindh, Christian LU ; Pedersen, Henning Sloth and Toft, Gunnar (2018) In Hormones and Behavior 101. p.105-112
Abstract

We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5–9 years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N = 1023) were analysed for perfluoroalkyl substances (PFASs) and categorised into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorised as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal... (More)

We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5–9 years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N = 1023) were analysed for perfluoroalkyl substances (PFASs) and categorised into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorised as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal PFHxS exposure was associated with 1.16 (95% confidence interval (CI): 0.08; 2.25) point higher SDQ-total (more problem behaviour) in Greenland and 0.80 (CI: 0.06; 1.54) point higher SDQ-total in the combined analyses, whereas no association was present in Ukraine alone. One natural log-unit increase in prenatal PFNA exposure was associated with 0.90 (CI: 0.10; 1.71) points higher SDQ-total in Greenland and 0.72 (CI: 0.13; 1.31) points higher in the combined analysis and no association in Ukraine. Prenatal PFAS exposure was unrelated to problem behaviour (abnormal SDQ-total). In the combined analysis, odds ratio (OR) (CI) for hyperactivity was 1.8 (1.0; 3.2) for one natural log-unit increase in prenatal PFNA and 1.7 (1.0; 3.1) for one natural log-unit increase in prenatal PFDA exposure. Findings are compatible with weak effects on child behaviour of prenatal exposure to some PFASs although spurious results are not entirely unlikely. The associations were strongest in Greenland.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Behaviour, Child, Child development, Cohort study, Fluorocarbons, Prenatal exposure, delayed effects
in
Hormones and Behavior
volume
101
pages
105 - 112
publisher
Elsevier
external identifiers
  • scopus:85044367640
ISSN
0018-506X
DOI
10.1016/j.yhbeh.2017.11.007
language
English
LU publication?
yes
id
a6dd9ec6-b59f-4ab3-af76-2eb91f37eec2
date added to LUP
2018-04-10 07:28:26
date last changed
2019-09-17 04:29:36
@article{a6dd9ec6-b59f-4ab3-af76-2eb91f37eec2,
  abstract     = {<p>We examined associations between prenatal exposure to perfluorohexane sulfonic acid (PFHxS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), and perfluorodecanic acid (PFDA) - and child behaviour (SDQ-total) and hyperactivity (sub-scale) at 5–9 years of age in birth cohorts from Greenland and Ukraine. Pregnancy serum samples (N = 1023) were analysed for perfluoroalkyl substances (PFASs) and categorised into tertiles and also used as continuous exposure variables. Problem behaviour and hyperactivity were assessed, using the Strength and Difficulties Questionnaire (SDQ) and categorised as normal/borderline and abnormal. Associations were analysed using multiple logistic and linear regression. High compared to low prenatal PFHxS exposure was associated with 1.16 (95% confidence interval (CI): 0.08; 2.25) point higher SDQ-total (more problem behaviour) in Greenland and 0.80 (CI: 0.06; 1.54) point higher SDQ-total in the combined analyses, whereas no association was present in Ukraine alone. One natural log-unit increase in prenatal PFNA exposure was associated with 0.90 (CI: 0.10; 1.71) points higher SDQ-total in Greenland and 0.72 (CI: 0.13; 1.31) points higher in the combined analysis and no association in Ukraine. Prenatal PFAS exposure was unrelated to problem behaviour (abnormal SDQ-total). In the combined analysis, odds ratio (OR) (CI) for hyperactivity was 1.8 (1.0; 3.2) for one natural log-unit increase in prenatal PFNA and 1.7 (1.0; 3.1) for one natural log-unit increase in prenatal PFDA exposure. Findings are compatible with weak effects on child behaviour of prenatal exposure to some PFASs although spurious results are not entirely unlikely. The associations were strongest in Greenland.</p>},
  author       = {Høyer, Birgit Bjerre and Bonde, Jens Peter and Tøttenborg, Sandra Søgaard and Ramlau-Hansen, Cecilia Høst and Lindh, Christian and Pedersen, Henning Sloth and Toft, Gunnar},
  issn         = {0018-506X},
  keyword      = {Behaviour,Child,Child development,Cohort study,Fluorocarbons,Prenatal exposure, delayed effects},
  language     = {eng},
  pages        = {105--112},
  publisher    = {Elsevier},
  series       = {Hormones and Behavior},
  title        = {Exposure to perfluoroalkyl substances during pregnancy and child behaviour at 5 to 9 years of age},
  url          = {http://dx.doi.org/10.1016/j.yhbeh.2017.11.007},
  volume       = {101},
  year         = {2018},
}