Human leukocyte antigen variation and Parkinson's disease.
Puschmann, Andreas LU
; Verbeeck, Christophe
; Heckman, Michael G
; Soto-Ortolaza, Alexandra I
; Lynch, Timothy
; Jasinska-Myga, Barbara
; Opala, Grzegorz
; Krygowska-Wajs, Anna
; Barcikowska, Maria
and Uitti, Ryan J
, et al.
(2011)
In Parkinsonism & Related Disorders
17.
p.376-378
- Abstract
- A role for the immune system in the pathogenesis of Parkinson's Disease (PD) has previously been suggested. A recent genome-wide association (GWA) study identified an association between one single nucleotide polymorphism (SNP) in the human leucocyte antigen (HLA) region (HLA-DRA rs3129882) and PD in a population of American patients with European ancestry. In that study, the minor rs3129882 allele (G) was associated with an increased risk of PD under an additive model. Due to the increased likelihood of obtaining false positive results in GWA studies compared to studies conducted based on a hypothesis-driven approach, repeated validation of findings from GWA studies are necessary. Herein, we evaluated the association between rs3129882 and... (More)
- A role for the immune system in the pathogenesis of Parkinson's Disease (PD) has previously been suggested. A recent genome-wide association (GWA) study identified an association between one single nucleotide polymorphism (SNP) in the human leucocyte antigen (HLA) region (HLA-DRA rs3129882) and PD in a population of American patients with European ancestry. In that study, the minor rs3129882 allele (G) was associated with an increased risk of PD under an additive model. Due to the increased likelihood of obtaining false positive results in GWA studies compared to studies conducted based on a hypothesis-driven approach, repeated validation of findings from GWA studies are necessary. Herein, we evaluated the association between rs3129882 and PD in three different Caucasian patient-control series (combined 1313 patients and 1305 controls) from the US, Ireland, and Poland. We observed no association (OR: 0.96, P = 0.50) between rs3129882 and PD when analyzing our data under an additive or dominant model. In contrast, when examined under a recessive model, the GG genotype was observed to be protective in the Irish (OR: 0.55, P = 0.008), Polish (OR: 0.67, P = 0.040) and combined (OR: 0.75, P = 0.006) patient-control series. In view of these diverging results, the exact role of genetic variation at the HLA region and susceptibility to PD remains to be resolved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1937263
- author
- Puschmann, Andreas
LU
; Verbeeck, Christophe
; Heckman, Michael G
; Soto-Ortolaza, Alexandra I
; Lynch, Timothy
; Jasinska-Myga, Barbara
; Opala, Grzegorz
; Krygowska-Wajs, Anna
; Barcikowska, Maria
and Uitti, Ryan J
, et al. (More)
- Puschmann, Andreas
LU
; Verbeeck, Christophe
; Heckman, Michael G
; Soto-Ortolaza, Alexandra I
; Lynch, Timothy
; Jasinska-Myga, Barbara
; Opala, Grzegorz
; Krygowska-Wajs, Anna
; Barcikowska, Maria
; Uitti, Ryan J
; Wszolek, Zbigniew K
and Ross, Owen A
(Less)
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Parkinsonism & Related Disorders
- volume
- 17
- pages
- 376 - 378
- publisher
- Elsevier
- external identifiers
-
- wos:000292487200015
- pmid:21482477
- scopus:79957935283
- ISSN
- 1873-5126
- DOI
- 10.1016/j.parkreldis.2011.03.008
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Division IV (013230800)
- id
- a6fd061b-7556-4425-aeab-f4ec0882076d (old id 1937263)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21482477?dopt=Abstract
- date added to LUP
- 2016-04-01 10:08:33
- date last changed
- 2023-08-30 18:44:27
@article{a6fd061b-7556-4425-aeab-f4ec0882076d,
abstract = {{A role for the immune system in the pathogenesis of Parkinson's Disease (PD) has previously been suggested. A recent genome-wide association (GWA) study identified an association between one single nucleotide polymorphism (SNP) in the human leucocyte antigen (HLA) region (HLA-DRA rs3129882) and PD in a population of American patients with European ancestry. In that study, the minor rs3129882 allele (G) was associated with an increased risk of PD under an additive model. Due to the increased likelihood of obtaining false positive results in GWA studies compared to studies conducted based on a hypothesis-driven approach, repeated validation of findings from GWA studies are necessary. Herein, we evaluated the association between rs3129882 and PD in three different Caucasian patient-control series (combined 1313 patients and 1305 controls) from the US, Ireland, and Poland. We observed no association (OR: 0.96, P = 0.50) between rs3129882 and PD when analyzing our data under an additive or dominant model. In contrast, when examined under a recessive model, the GG genotype was observed to be protective in the Irish (OR: 0.55, P = 0.008), Polish (OR: 0.67, P = 0.040) and combined (OR: 0.75, P = 0.006) patient-control series. In view of these diverging results, the exact role of genetic variation at the HLA region and susceptibility to PD remains to be resolved.}},
author = {{Puschmann, Andreas and Verbeeck, Christophe and Heckman, Michael G and Soto-Ortolaza, Alexandra I and Lynch, Timothy and Jasinska-Myga, Barbara and Opala, Grzegorz and Krygowska-Wajs, Anna and Barcikowska, Maria and Uitti, Ryan J and Wszolek, Zbigniew K and Ross, Owen A}},
issn = {{1873-5126}},
language = {{eng}},
pages = {{376--378}},
publisher = {{Elsevier}},
series = {{Parkinsonism & Related Disorders}},
title = {{Human leukocyte antigen variation and Parkinson's disease.}},
url = {{https://lup.lub.lu.se/search/files/1598753/1971376.pdf}},
doi = {{10.1016/j.parkreldis.2011.03.008}},
volume = {{17}},
year = {{2011}},
}