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Incidence of Pediatric Celiac Disease Varies by Region

Stahl, Marisa ; Li, Qian ; Lynch, Kristian ; Koletzko, Sibylle ; Mehta, Pooja ; Gragert, Loren ; Norris, Jill M. ; Andrén Aronsson, Carin LU orcid ; Lindfors, Katri and Kurppa, Kalle , et al. (2023) In American Journal of Gastroenterology 118(3). p.539-545
Abstract

INTRODUCTION:The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions within Europe and the United States. Our aim was to identify regional differences in CD autoimmunity and CD cumulative incidence for children born between 2004 and 2010.METHODS:Children (n = 6,628) with DQ2.5 and/or DQ8.1 were enrolled prospectively from birth in Georgia, Washington, Colorado, Finland, Germany, and Sweden. Children underwent periodic study screening for tissue transglutaminase antibodies and then CD evaluation per clinical care. Population-specific estimates were calculated by weighting... (More)

INTRODUCTION:The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions within Europe and the United States. Our aim was to identify regional differences in CD autoimmunity and CD cumulative incidence for children born between 2004 and 2010.METHODS:Children (n = 6,628) with DQ2.5 and/or DQ8.1 were enrolled prospectively from birth in Georgia, Washington, Colorado, Finland, Germany, and Sweden. Children underwent periodic study screening for tissue transglutaminase antibodies and then CD evaluation per clinical care. Population-specific estimates were calculated by weighting the study-specific cumulative incidence with the population-specific haplogenotype frequencies obtained from large stem cell registries from each site.RESULTS:Individual haplogenotype risks for CD autoimmunity and CD varied by region and affected the cumulative incidence within that region. The CD incidence by age 10 years was highest in Swedish children at 3%. Within the United States, the incidence by age 10 years in Colorado was 2.4%. In the model adjusted for HLA, sex, and family history, Colorado children had a 2.5-fold higher risk of CD compared to Washington. Likewise, Swedish children had a 1.4-fold and 1.8-fold higher risk of CD compared with those in Finland and Germany, respectively.DISCUSSION:There is high regional variability in cumulative incidence of CD, which suggests differential environmental, genetic, and epigenetic influences even within the United States. The overall high incidence warrants a low threshold for screening and further research on region-specific CD triggers.

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type
Contribution to journal
publication status
published
subject
in
American Journal of Gastroenterology
volume
118
issue
3
pages
7 pages
publisher
Wolters Kluwer
external identifiers
  • pmid:36219178
  • scopus:85149420541
ISSN
0002-9270
DOI
10.14309/ajg.0000000000002056
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2023 Wolters Kluwer Health. All rights reserved.
id
a75afc12-4a5e-4612-b47a-64e048bb8554
date added to LUP
2024-01-12 14:42:04
date last changed
2024-04-13 08:09:31
@article{a75afc12-4a5e-4612-b47a-64e048bb8554,
  abstract     = {{<p>INTRODUCTION:The Environmental Determinants of Diabetes in the Young study follows an HLA risk selected birth cohort for celiac disease (CD) development using a uniform protocol. Children under investigation come from 6 different regions within Europe and the United States. Our aim was to identify regional differences in CD autoimmunity and CD cumulative incidence for children born between 2004 and 2010.METHODS:Children (n = 6,628) with DQ2.5 and/or DQ8.1 were enrolled prospectively from birth in Georgia, Washington, Colorado, Finland, Germany, and Sweden. Children underwent periodic study screening for tissue transglutaminase antibodies and then CD evaluation per clinical care. Population-specific estimates were calculated by weighting the study-specific cumulative incidence with the population-specific haplogenotype frequencies obtained from large stem cell registries from each site.RESULTS:Individual haplogenotype risks for CD autoimmunity and CD varied by region and affected the cumulative incidence within that region. The CD incidence by age 10 years was highest in Swedish children at 3%. Within the United States, the incidence by age 10 years in Colorado was 2.4%. In the model adjusted for HLA, sex, and family history, Colorado children had a 2.5-fold higher risk of CD compared to Washington. Likewise, Swedish children had a 1.4-fold and 1.8-fold higher risk of CD compared with those in Finland and Germany, respectively.DISCUSSION:There is high regional variability in cumulative incidence of CD, which suggests differential environmental, genetic, and epigenetic influences even within the United States. The overall high incidence warrants a low threshold for screening and further research on region-specific CD triggers.</p>}},
  author       = {{Stahl, Marisa and Li, Qian and Lynch, Kristian and Koletzko, Sibylle and Mehta, Pooja and Gragert, Loren and Norris, Jill M. and Andrén Aronsson, Carin and Lindfors, Katri and Kurppa, Kalle and Ilonen, Jorma and Krischer, Jeffrey and Alkolkar, Beena and Ziegler, Anette G. and Toppari, Jorma and Rewers, Marian J. and Agardh, Daniel and Hagopian, William and Liu, Edwin}},
  issn         = {{0002-9270}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{539--545}},
  publisher    = {{Wolters Kluwer}},
  series       = {{American Journal of Gastroenterology}},
  title        = {{Incidence of Pediatric Celiac Disease Varies by Region}},
  url          = {{http://dx.doi.org/10.14309/ajg.0000000000002056}},
  doi          = {{10.14309/ajg.0000000000002056}},
  volume       = {{118}},
  year         = {{2023}},
}