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The plasma protein profile and cardiovascular risk differ between intima-media thickness of the common carotid artery and the bulb : A meta-analysis and a longitudinal evaluation

Lind, Lars ; Gigante, Bruna ; Borne, Yan LU ; Mälarstig, Anders ; Sundström, Johan ; Ärnlöv, Johan ; Ingelsson, Erik ; Baldassarre, Damiano ; Tremoli, Elena and Veglia, Fabrizio , et al. (2020) In Atherosclerosis 295. p.25-30
Abstract

Background and aims: Genetic loci associated with CHD show different relationships with intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. Methods: In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n > 7000), IMT-CCA and IMT-bulb were assessed by ultrasound at baseline, and 86 cardiovascular-related proteins were analyzed. In the PIVUS study only, IMT-CCA and IMT-bulb were investigated in relation to incident atherosclerotic disease over 10 years of follow-up. Results: In a meta-analysis of the analysis performed separately in the cohorts, three proteins,... (More)

Background and aims: Genetic loci associated with CHD show different relationships with intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. Methods: In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n > 7000), IMT-CCA and IMT-bulb were assessed by ultrasound at baseline, and 86 cardiovascular-related proteins were analyzed. In the PIVUS study only, IMT-CCA and IMT-bulb were investigated in relation to incident atherosclerotic disease over 10 years of follow-up. Results: In a meta-analysis of the analysis performed separately in the cohorts, three proteins, matrix metalloproteinase-12 (MMP-12), hepatocyte growth factor (HGF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), were associated with IMT-CCA when adjusted for traditional cardiovascular risk factors. Five proteins were associated with IMT-bulb (MMP-12, growth/differentiation factor 15 (GDF-15), osteoprotegerin, growth hormone and renin). Following adjustment for cardiovascular risk factors, IMT-bulb was significantly more closely related to incident stroke or myocardial infarction (total number of cases, 111) than IMT-CCA in the PIVUS study (HR 1.51 for 1 SD, 95%CI 1.21–1.87, p < 0.001 vs HR 1.17, 95%CI 0.93–1.47, p = 0.16). MMP-12 levels were related to this combined end-point (HR 1.30, 95%CI 1.08–1.56, p = 0.0061). Conclusions: Elevated levels of MMP-12 were associated with both IMT-CCA and IMT-bulb, but other proteins were significantly related to IMT in only one of these locations. The finding that IMT-bulb was more closely related to incident atherosclerotic disease than IMT-CCA emphasizes a difference between these measurements of IMT.

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type
Contribution to journal
publication status
published
subject
keywords
Atherosclerosis, Carotid artery, Meta-analysis, Proteomics, Ultrasound
in
Atherosclerosis
volume
295
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85078552368
  • pmid:31981948
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2020.01.011
language
English
LU publication?
yes
id
a7e169d3-3339-4e5a-88fe-f709ada61ac7
date added to LUP
2020-12-28 12:29:47
date last changed
2025-01-10 00:57:19
@article{a7e169d3-3339-4e5a-88fe-f709ada61ac7,
  abstract     = {{<p>Background and aims: Genetic loci associated with CHD show different relationships with intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. Methods: In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n &gt; 7000), IMT-CCA and IMT-bulb were assessed by ultrasound at baseline, and 86 cardiovascular-related proteins were analyzed. In the PIVUS study only, IMT-CCA and IMT-bulb were investigated in relation to incident atherosclerotic disease over 10 years of follow-up. Results: In a meta-analysis of the analysis performed separately in the cohorts, three proteins, matrix metalloproteinase-12 (MMP-12), hepatocyte growth factor (HGF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), were associated with IMT-CCA when adjusted for traditional cardiovascular risk factors. Five proteins were associated with IMT-bulb (MMP-12, growth/differentiation factor 15 (GDF-15), osteoprotegerin, growth hormone and renin). Following adjustment for cardiovascular risk factors, IMT-bulb was significantly more closely related to incident stroke or myocardial infarction (total number of cases, 111) than IMT-CCA in the PIVUS study (HR 1.51 for 1 SD, 95%CI 1.21–1.87, p &lt; 0.001 vs HR 1.17, 95%CI 0.93–1.47, p = 0.16). MMP-12 levels were related to this combined end-point (HR 1.30, 95%CI 1.08–1.56, p = 0.0061). Conclusions: Elevated levels of MMP-12 were associated with both IMT-CCA and IMT-bulb, but other proteins were significantly related to IMT in only one of these locations. The finding that IMT-bulb was more closely related to incident atherosclerotic disease than IMT-CCA emphasizes a difference between these measurements of IMT.</p>}},
  author       = {{Lind, Lars and Gigante, Bruna and Borne, Yan and Mälarstig, Anders and Sundström, Johan and Ärnlöv, Johan and Ingelsson, Erik and Baldassarre, Damiano and Tremoli, Elena and Veglia, Fabrizio and Hamsten, Anders and Orho-Melander, Marju and Nilsson, Jan and Melander, Olle and Engström, Gunnar}},
  issn         = {{0021-9150}},
  keywords     = {{Atherosclerosis; Carotid artery; Meta-analysis; Proteomics; Ultrasound}},
  language     = {{eng}},
  pages        = {{25--30}},
  publisher    = {{Elsevier}},
  series       = {{Atherosclerosis}},
  title        = {{The plasma protein profile and cardiovascular risk differ between intima-media thickness of the common carotid artery and the bulb : A meta-analysis and a longitudinal evaluation}},
  url          = {{http://dx.doi.org/10.1016/j.atherosclerosis.2020.01.011}},
  doi          = {{10.1016/j.atherosclerosis.2020.01.011}},
  volume       = {{295}},
  year         = {{2020}},
}