The Typology of Alcohol Use Disorder : Latent Class Analyses of a Population-Based Swedish Sample
(2022) In Journal of Studies on Alcohol and Drugs 83(5). p.672-679- Abstract
Objective: The purpose of this study was to clarify the clinical heterogeneity of alcohol use disorder (AUD) in a national Swedish sample of affected individuals using latent class analysis. Method: Using a Swedish population-based sample of AUD cases ascertained from medical, criminal, and pharmacy registries (n = 217,071), we applied latent class analysis to sex, externalizing and internalizing syndromes before first registration, and age at first registration. The re-sulting types were evaluated against 15 diverse validators and degree of resemblance in relative pairs concordant for AUD. Results: A three-class solution was preferred by fit indices. The three classes were as follows: type 1 (male preponderant, externalizing; 32%),... (More)
Objective: The purpose of this study was to clarify the clinical heterogeneity of alcohol use disorder (AUD) in a national Swedish sample of affected individuals using latent class analysis. Method: Using a Swedish population-based sample of AUD cases ascertained from medical, criminal, and pharmacy registries (n = 217,071), we applied latent class analysis to sex, externalizing and internalizing syndromes before first registration, and age at first registration. The re-sulting types were evaluated against 15 diverse validators and degree of resemblance in relative pairs concordant for AUD. Results: A three-class solution was preferred by fit indices. The three classes were as follows: type 1 (male preponderant, externalizing; 32%), type 2 (minimal prior psychopathology; 46%), and type 3 (mixed-sex internalizing; 23%). Repeated split-half analyses revealed the statistical stability of these solutions. Meaningful differences emerged between the classes on many validators. Type 1 had the greatest family disruption, lowest educational levels, most AUD registrations, highest rates of criminal registration, and highest genetic risk for externalizing disorders and AUD. Type 2 had the least social dysfunction. Type 3 had the highest educational attainment, genetic liability to internalizing disorders, and proportion of women. All types significantly aggregated in affected pairs of relatives. Conclu-sions: Meaningful and reproducible subtypes of AUD, consistent with prior typological results, can be obtained from national registry–based samples. Using a range of external validators and patterns of familial aggregation, our results suggest that our three-class solution captured a meaningful proportion of the clinical heterogeneity of AUD.
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- author
- Kendler, Kenneth S. ; Ohlsson, Henrik LU ; Sundquist, Jan LU and Sundquist, Kristina LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Studies on Alcohol and Drugs
- volume
- 83
- issue
- 5
- pages
- 8 pages
- publisher
- Alcohol Research Documentation, Inc.
- external identifiers
-
- pmid:36136437
- scopus:85138459872
- ISSN
- 1937-1888
- DOI
- 10.15288/jsad.21-00409
- language
- English
- LU publication?
- yes
- id
- a82cd530-273f-400d-b5b6-f41d097b1821
- date added to LUP
- 2023-01-19 15:47:13
- date last changed
- 2024-04-18 18:14:25
@article{a82cd530-273f-400d-b5b6-f41d097b1821,
abstract = {{<p>Objective: The purpose of this study was to clarify the clinical heterogeneity of alcohol use disorder (AUD) in a national Swedish sample of affected individuals using latent class analysis. Method: Using a Swedish population-based sample of AUD cases ascertained from medical, criminal, and pharmacy registries (n = 217,071), we applied latent class analysis to sex, externalizing and internalizing syndromes before first registration, and age at first registration. The re-sulting types were evaluated against 15 diverse validators and degree of resemblance in relative pairs concordant for AUD. Results: A three-class solution was preferred by fit indices. The three classes were as follows: type 1 (male preponderant, externalizing; 32%), type 2 (minimal prior psychopathology; 46%), and type 3 (mixed-sex internalizing; 23%). Repeated split-half analyses revealed the statistical stability of these solutions. Meaningful differences emerged between the classes on many validators. Type 1 had the greatest family disruption, lowest educational levels, most AUD registrations, highest rates of criminal registration, and highest genetic risk for externalizing disorders and AUD. Type 2 had the least social dysfunction. Type 3 had the highest educational attainment, genetic liability to internalizing disorders, and proportion of women. All types significantly aggregated in affected pairs of relatives. Conclu-sions: Meaningful and reproducible subtypes of AUD, consistent with prior typological results, can be obtained from national registry–based samples. Using a range of external validators and patterns of familial aggregation, our results suggest that our three-class solution captured a meaningful proportion of the clinical heterogeneity of AUD.</p>}},
author = {{Kendler, Kenneth S. and Ohlsson, Henrik and Sundquist, Jan and Sundquist, Kristina}},
issn = {{1937-1888}},
language = {{eng}},
number = {{5}},
pages = {{672--679}},
publisher = {{Alcohol Research Documentation, Inc.}},
series = {{Journal of Studies on Alcohol and Drugs}},
title = {{The Typology of Alcohol Use Disorder : Latent Class Analyses of a Population-Based Swedish Sample}},
url = {{http://dx.doi.org/10.15288/jsad.21-00409}},
doi = {{10.15288/jsad.21-00409}},
volume = {{83}},
year = {{2022}},
}