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Exposure to phenoxyacetic acids and glyphosate as risk factors for non-Hodgkin lymphoma– pooled analysis of three Swedish case-control studies including the sub-type hairy cell leukemia

Hardell, Lennart ; Carlberg, Michael ; Nordström, Marie and Eriksson, Mikael LU orcid (2023) In Leukemia and Lymphoma 64(5). p.997-1004
Abstract

The association between pesticide exposure and non-Hodgkin lymphoma (NHL) including hairy cell leukemia (HCL) was analyzed in a pooled study of three case-control studies. Results on exposure to pesticides were based on 1,425 cases and 2,157 controls participating in the studies. Exposures were assessed by self-administered questionnaires completed as needed by phone. In the pooled univariate analyses adjusted by age, gender and year of diagnosis, exposure to herbicides of the phenoxyacetic acid type yielded statistically significant increased risk with odds ratio (OR) = 1.9, 95% confidence interval CI) = 1.4–2.5. The herbicide glyphosate gave OR = 2.2, 95% CI = 1.3–3.8. Impregnating agents increased the risk. No clear dose-response... (More)

The association between pesticide exposure and non-Hodgkin lymphoma (NHL) including hairy cell leukemia (HCL) was analyzed in a pooled study of three case-control studies. Results on exposure to pesticides were based on 1,425 cases and 2,157 controls participating in the studies. Exposures were assessed by self-administered questionnaires completed as needed by phone. In the pooled univariate analyses adjusted by age, gender and year of diagnosis, exposure to herbicides of the phenoxyacetic acid type yielded statistically significant increased risk with odds ratio (OR) = 1.9, 95% confidence interval CI) = 1.4–2.5. The herbicide glyphosate gave OR = 2.2, 95% CI = 1.3–3.8. Impregnating agents increased the risk. No clear dose-response effect was seen. OR was highest in the >10–20 years latency group for herbicides and impregnating agents. In the multivariate analysis including main pesticide groups, statistically significant increased risk was found for herbicides, OR = 1.6, 95% CI = 1.2–2.1 and impregnating agents with OR = 1.4, 95% CI = 1.1–1.8. This analysis confirmed an association between NHL including HCL and exposure to certain herbicides.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
glyphosate, hairy cell leukemia, Non-Hodgkin lymphoma, pesticides, phenoxyacetic acids
in
Leukemia and Lymphoma
volume
64
issue
5
pages
997 - 1004
publisher
Taylor & Francis
external identifiers
  • pmid:36938909
  • scopus:85150865021
ISSN
1042-8194
DOI
10.1080/10428194.2023.2190434
language
English
LU publication?
yes
id
a8bab3b0-c00c-4550-9b79-34229c356882
date added to LUP
2023-05-26 13:45:46
date last changed
2024-10-05 15:22:50
@article{a8bab3b0-c00c-4550-9b79-34229c356882,
  abstract     = {{<p>The association between pesticide exposure and non-Hodgkin lymphoma (NHL) including hairy cell leukemia (HCL) was analyzed in a pooled study of three case-control studies. Results on exposure to pesticides were based on 1,425 cases and 2,157 controls participating in the studies. Exposures were assessed by self-administered questionnaires completed as needed by phone. In the pooled univariate analyses adjusted by age, gender and year of diagnosis, exposure to herbicides of the phenoxyacetic acid type yielded statistically significant increased risk with odds ratio (OR) = 1.9, 95% confidence interval CI) = 1.4–2.5. The herbicide glyphosate gave OR = 2.2, 95% CI = 1.3–3.8. Impregnating agents increased the risk. No clear dose-response effect was seen. OR was highest in the &gt;10–20 years latency group for herbicides and impregnating agents. In the multivariate analysis including main pesticide groups, statistically significant increased risk was found for herbicides, OR = 1.6, 95% CI = 1.2–2.1 and impregnating agents with OR = 1.4, 95% CI = 1.1–1.8. This analysis confirmed an association between NHL including HCL and exposure to certain herbicides.</p>}},
  author       = {{Hardell, Lennart and Carlberg, Michael and Nordström, Marie and Eriksson, Mikael}},
  issn         = {{1042-8194}},
  keywords     = {{glyphosate; hairy cell leukemia; Non-Hodgkin lymphoma; pesticides; phenoxyacetic acids}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{997--1004}},
  publisher    = {{Taylor & Francis}},
  series       = {{Leukemia and Lymphoma}},
  title        = {{Exposure to phenoxyacetic acids and glyphosate as risk factors for non-Hodgkin lymphoma– pooled analysis of three Swedish case-control studies including the sub-type hairy cell leukemia}},
  url          = {{http://dx.doi.org/10.1080/10428194.2023.2190434}},
  doi          = {{10.1080/10428194.2023.2190434}},
  volume       = {{64}},
  year         = {{2023}},
}