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Celiac disease : A review of current concepts in pathogenesis, prevention, and novel therapies

Tye-Din, Jason A. ; Galipeau, Heather J. and Agardh, Daniel LU (2018) In Frontiers in Pediatrics 6.
Abstract

Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. These studies underscore the importance of specific HLA susceptibility genes and gluten consumption in disease development and suggest that other genetic and environmental factors could also play a role. The emerging data on viral and bacterial microbe-host interactions and their alterations in celiac disease provides a plausible mechanism linking... (More)

Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. These studies underscore the importance of specific HLA susceptibility genes and gluten consumption in disease development and suggest that other genetic and environmental factors could also play a role. The emerging data on viral and bacterial microbe-host interactions and their alterations in celiac disease provides a plausible mechanism linking environmental risk and disease development. Although the inflammatory lesion of celiac disease is complex, the strong HLA association highlights a central role for pathogenic T cells responding to select gluten peptides that have now been defined for the most common genetic form of celiac disease. What remains less understood is how loss of tolerance to gluten occurs. New insights into celiac disease are now providing opportunities to intervene in its development, course, diagnosis, and treatment.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Celiac disease, Gluten, Microbiome, Pathogenesis, T cells
in
Frontiers in Pediatrics
volume
6
article number
00350
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85058211429
  • pmid:30519552
DOI
10.3389/fped.2018.00350
language
English
LU publication?
yes
id
a8f5620f-0dd5-4777-ad63-5be06a43bd10
date added to LUP
2019-01-09 14:29:22
date last changed
2020-01-22 07:23:58
@article{a8f5620f-0dd5-4777-ad63-5be06a43bd10,
  abstract     = {<p>Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. These studies underscore the importance of specific HLA susceptibility genes and gluten consumption in disease development and suggest that other genetic and environmental factors could also play a role. The emerging data on viral and bacterial microbe-host interactions and their alterations in celiac disease provides a plausible mechanism linking environmental risk and disease development. Although the inflammatory lesion of celiac disease is complex, the strong HLA association highlights a central role for pathogenic T cells responding to select gluten peptides that have now been defined for the most common genetic form of celiac disease. What remains less understood is how loss of tolerance to gluten occurs. New insights into celiac disease are now providing opportunities to intervene in its development, course, diagnosis, and treatment.</p>},
  author       = {Tye-Din, Jason A. and Galipeau, Heather J. and Agardh, Daniel},
  language     = {eng},
  publisher    = {Frontiers Media S. A.},
  series       = {Frontiers in Pediatrics},
  title        = {Celiac disease : A review of current concepts in pathogenesis, prevention, and novel therapies},
  url          = {http://dx.doi.org/10.3389/fped.2018.00350},
  doi          = {10.3389/fped.2018.00350},
  volume       = {6},
  year         = {2018},
}