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An ecoimmunological approach to study evolutionary and ancient links between coagulation, complement and Innate immunity

Papareddy, Praveen LU orcid ; Kasetty, Gopinath LU ; Alyafei, Saud ; Smeds, Emanuel LU ; Salo-Ahen, Outi M.H. ; Hansson, Stefan R. LU orcid ; Egesten, Arne LU and Herwald, Heiko LU orcid (2018) In Virulence 9(1). p.724-737
Abstract

Coagulation, complement, and innate immunity are tightly interwoven and form an alliance that can be traced back to early eukaryotic evolution. Here we employed an ecoimmunological approach using Tissue Factor Pathway Inhibitor (TFPI)-1-derived peptides from the different classes of vertebrates (i.e. fish, reptile, bird, and mammals) and tested whether they can boost killing of various human bacterial pathogens in plasma. We found signs of species-specific conservation and diversification during evolution in these peptides that significantly impact their antibacterial activity. Though all peptides tested executed bactericidal activity in mammalian plasma (with the exception of rodents), no killing was observed in plasma from birds,... (More)

Coagulation, complement, and innate immunity are tightly interwoven and form an alliance that can be traced back to early eukaryotic evolution. Here we employed an ecoimmunological approach using Tissue Factor Pathway Inhibitor (TFPI)-1-derived peptides from the different classes of vertebrates (i.e. fish, reptile, bird, and mammals) and tested whether they can boost killing of various human bacterial pathogens in plasma. We found signs of species-specific conservation and diversification during evolution in these peptides that significantly impact their antibacterial activity. Though all peptides tested executed bactericidal activity in mammalian plasma (with the exception of rodents), no killing was observed in plasma from birds, reptiles, and fish, pointing to a crucial role for the classical pathway of the complement system. We also observed an interference of these peptides with the human intrinsic pathway of coagulation though, unlike complement activation, this mechanism appears not to be evolutionary conserved.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antimicrobial, coagulation, complement, evolution, IgG, Immunoglobulins, peptide, TFPI-1, vertebrates
in
Virulence
volume
9
issue
1
pages
14 pages
publisher
Landes Bioscience
external identifiers
  • scopus:85053111928
  • pmid:29473457
ISSN
2150-5608
DOI
10.1080/21505594.2018.1441589
language
English
LU publication?
yes
id
a9465092-563f-4362-8e4b-c3b093947dc6
date added to LUP
2018-10-08 10:26:32
date last changed
2024-04-01 12:01:46
@article{a9465092-563f-4362-8e4b-c3b093947dc6,
  abstract     = {{<p>Coagulation, complement, and innate immunity are tightly interwoven and form an alliance that can be traced back to early eukaryotic evolution. Here we employed an ecoimmunological approach using Tissue Factor Pathway Inhibitor (TFPI)-1-derived peptides from the different classes of vertebrates (i.e. fish, reptile, bird, and mammals) and tested whether they can boost killing of various human bacterial pathogens in plasma. We found signs of species-specific conservation and diversification during evolution in these peptides that significantly impact their antibacterial activity. Though all peptides tested executed bactericidal activity in mammalian plasma (with the exception of rodents), no killing was observed in plasma from birds, reptiles, and fish, pointing to a crucial role for the classical pathway of the complement system. We also observed an interference of these peptides with the human intrinsic pathway of coagulation though, unlike complement activation, this mechanism appears not to be evolutionary conserved.</p>}},
  author       = {{Papareddy, Praveen and Kasetty, Gopinath and Alyafei, Saud and Smeds, Emanuel and Salo-Ahen, Outi M.H. and Hansson, Stefan R. and Egesten, Arne and Herwald, Heiko}},
  issn         = {{2150-5608}},
  keywords     = {{antimicrobial; coagulation; complement; evolution; IgG; Immunoglobulins; peptide; TFPI-1; vertebrates}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  pages        = {{724--737}},
  publisher    = {{Landes Bioscience}},
  series       = {{Virulence}},
  title        = {{An ecoimmunological approach to study evolutionary and ancient links between coagulation, complement and Innate immunity}},
  url          = {{http://dx.doi.org/10.1080/21505594.2018.1441589}},
  doi          = {{10.1080/21505594.2018.1441589}},
  volume       = {{9}},
  year         = {{2018}},
}