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Reservoir Pressure Integral Is Independently Associated With the Reduction in Renal Function in Older Adults

Aizawa, Kunihiko ; Hughes, Alun D. ; Casanova, Francesco ; Gates, Phillip E. ; Mawson, David M. ; Gooding, Kim M. ; Gilchrist, Mark ; Goncalves, Isabel LU orcid ; Nilsson, Jan LU and Khan, Faisel , et al. (2022) In Hypertension 79(10). p.2364-2372
Abstract

Background: Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimated glomerular filtration rate in 542 older adults (69.4±7.9 years, 194 females) at baseline and after 3 years. Methods: Reservoir-excess pressure parameters, including reservoir pressure integral, excess pressure integral, systolic, and diastolic rate constants, were obtained by radial artery tonometry. Results: After 3 years, and in a group of... (More)

Background: Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimated glomerular filtration rate in 542 older adults (69.4±7.9 years, 194 females) at baseline and after 3 years. Methods: Reservoir-excess pressure parameters, including reservoir pressure integral, excess pressure integral, systolic, and diastolic rate constants, were obtained by radial artery tonometry. Results: After 3 years, and in a group of 94 individuals (72.4±7.6 years, 26 females), there was an estimated glomerular filtration rate reduction of >5% per year (median reduction of 20.5% over 3 years). A multivariable logistic regression analysis revealed that higher baseline reservoir pressure integral was independently associated with a smaller reduction in estimated glomerular filtration rate after accounting for conventional cardiovascular risk factors and study centers (odds ratio: 0.660 [95% CIs, 0.494-0.883]; P=0.005). The association remained unchanged after further adjustments for potential confounders and baseline renal function (odds ratio: 0.528 [95% CIs, 0.351-0.794]; P=0.002). No other reservoir-excess pressure parameters exhibited associations with the reduction in renal function. Conclusions: This study demonstrates that baseline reservoir pressure integral was associated with the decline in renal function in older adults at 3-year follow-up, independently of conventional cardiovascular risk factors. This suggests that reservoir pressure integral may play a role in the functional decline of the kidneys.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, Blood pressure, Hemodynamics, Kidney, Risk factors
in
Hypertension
volume
79
issue
10
pages
9 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:35993228
  • scopus:85137765720
ISSN
0194-911X
DOI
10.1161/HYPERTENSIONAHA.122.19483
language
English
LU publication?
yes
id
a95d6e37-bdc0-41f6-b3a0-8633cfcc34f2
date added to LUP
2022-11-30 11:27:45
date last changed
2024-06-11 19:57:40
@article{a95d6e37-bdc0-41f6-b3a0-8633cfcc34f2,
  abstract     = {{<p>Background: Arterial hemodynamic parameters derived from reservoir-excess pressure analysis exhibit prognostic utility. Reservoir-excess pressure analysis may provide useful information about an influence of altered hemodynamics on target organ such as the kidneys. We determined whether the parameters derived from the reservoir-excess pressure analysis were associated with the reduction in estimated glomerular filtration rate in 542 older adults (69.4±7.9 years, 194 females) at baseline and after 3 years. Methods: Reservoir-excess pressure parameters, including reservoir pressure integral, excess pressure integral, systolic, and diastolic rate constants, were obtained by radial artery tonometry. Results: After 3 years, and in a group of 94 individuals (72.4±7.6 years, 26 females), there was an estimated glomerular filtration rate reduction of &gt;5% per year (median reduction of 20.5% over 3 years). A multivariable logistic regression analysis revealed that higher baseline reservoir pressure integral was independently associated with a smaller reduction in estimated glomerular filtration rate after accounting for conventional cardiovascular risk factors and study centers (odds ratio: 0.660 [95% CIs, 0.494-0.883]; P=0.005). The association remained unchanged after further adjustments for potential confounders and baseline renal function (odds ratio: 0.528 [95% CIs, 0.351-0.794]; P=0.002). No other reservoir-excess pressure parameters exhibited associations with the reduction in renal function. Conclusions: This study demonstrates that baseline reservoir pressure integral was associated with the decline in renal function in older adults at 3-year follow-up, independently of conventional cardiovascular risk factors. This suggests that reservoir pressure integral may play a role in the functional decline of the kidneys.</p>}},
  author       = {{Aizawa, Kunihiko and Hughes, Alun D. and Casanova, Francesco and Gates, Phillip E. and Mawson, David M. and Gooding, Kim M. and Gilchrist, Mark and Goncalves, Isabel and Nilsson, Jan and Khan, Faisel and Colhoun, Helen M. and Palombo, Carlo and Parker, Kim H. and Shore, Angela C.}},
  issn         = {{0194-911X}},
  keywords     = {{Aging; Blood pressure; Hemodynamics; Kidney; Risk factors}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{10}},
  pages        = {{2364--2372}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Hypertension}},
  title        = {{Reservoir Pressure Integral Is Independently Associated With the Reduction in Renal Function in Older Adults}},
  url          = {{http://dx.doi.org/10.1161/HYPERTENSIONAHA.122.19483}},
  doi          = {{10.1161/HYPERTENSIONAHA.122.19483}},
  volume       = {{79}},
  year         = {{2022}},
}