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Association between CD8(+) T cell subsets and cardiovascular disease.

Kolbus, Daniel; Ljungcrantz, Irena LU ; Andersson, Linda LU ; Hedblad, Bo LU ; Nordin Fredrikson, Gunilla LU ; Björkbacka, Harry LU and Nilsson, Jan (2013) In Journal of Internal Medicine1989-01-01+01:00 274(1). p.41-51
Abstract
OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events. DESIGN: The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140°C, were thawed and the different CD8(+) T cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by... (More)
OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events. DESIGN: The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140°C, were thawed and the different CD8(+) T cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. RESULTS: Subjects with a high fraction of CD8(+) T cells were characterized by decreased cytokine release from activated leukocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8(+) T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8(+) CD25(+) T cells and the degree of carotid stenosis (r=0.11, P<0.01), and between the CD8(+) CD56(-) IFN-γ(+) T cell fraction and the degree of stenosis (r=-0.18, P<0.005). The association between CD8(+) CD56(-) IFN-γ(+) T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. CONCLUSION: The present study provides prospective clinical evidence for a role of CD8(+) T cells in cardiovascular disease and suggests the existence of CD8(+) T cell subsets with different pathological functions. © 2013 The Association for the Publication of the Journal of Internal Medicine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine1989-01-01+01:00
volume
274
issue
1
pages
41 - 51
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000320279000003
  • pmid:23356723
  • scopus:84879109428
ISSN
1365-2796
DOI
10.1111/joim.12038
language
English
LU publication?
yes
id
a973b387-55ea-4d3a-b656-076896143250 (old id 3438206)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23356723?dopt=Abstract
date added to LUP
2013-02-04 17:55:55
date last changed
2019-05-14 01:36:38
@article{a973b387-55ea-4d3a-b656-076896143250,
  abstract     = {OBJECTIVES: The findings of experimental studies suggest that the immune system plays a key role in atherosclerosis but the clinical importance of different immune cells in cardiovascular disease remains poorly characterized. In this study we investigated the association between CD8(+) T cells and carotid disease as well as development of cardiovascular disease events. DESIGN: The study cohort comprised 700 subjects from the cardiovascular arm of the Malmö Diet and Cancer Study. Peripheral blood mononuclear cells, obtained at the 1991-1994 baseline investigation and stored at -140°C, were thawed and the different CD8(+) T cell populations analysed by flow cytometry. Baseline carotid intima-media thickness and stenosis were assessed by ultrasonography and clinical events were monitored through validated national registers. RESULTS: Subjects with a high fraction of CD8(+) T cells were characterized by decreased cytokine release from activated leukocytes, metabolic signs of insulin resistance and increased incidence of coronary events; hazard ratios (95% confidence intervals) for the second and third tertiles of CD8(+) T cells were 2.57 (1.16, 5.67) and 2.61 (1.19, 5,71), respectively, in a Cox proportional hazards regression model. Correlations were found between the fraction of CD8(+) CD25(+) T cells and the degree of carotid stenosis (r=0.11, P&lt;0.01), and between the CD8(+) CD56(-) IFN-γ(+) T cell fraction and the degree of stenosis (r=-0.18, P&lt;0.005). The association between CD8(+) CD56(-) IFN-γ(+) T cells and carotid stenosis remained significant after controlling for major cardiovascular disease risk factors. CONCLUSION: The present study provides prospective clinical evidence for a role of CD8(+) T cells in cardiovascular disease and suggests the existence of CD8(+) T cell subsets with different pathological functions. © 2013 The Association for the Publication of the Journal of Internal Medicine.},
  author       = {Kolbus, Daniel and Ljungcrantz, Irena and Andersson, Linda and Hedblad, Bo and Nordin Fredrikson, Gunilla and Björkbacka, Harry and Nilsson, Jan},
  issn         = {1365-2796},
  language     = {eng},
  number       = {1},
  pages        = {41--51},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine1989-01-01+01:00},
  title        = {Association between CD8(+) T cell subsets and cardiovascular disease.},
  url          = {http://dx.doi.org/10.1111/joim.12038},
  volume       = {274},
  year         = {2013},
}