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Insulin resistance and its relationship with long-term exposure to ozone : Data based on a national population cohort

Zhang, Zenglei ; Luan, Cheng LU ; Wang, Chunqi ; Li, Tiantian ; Wu, Yi ; Huang, Xin ; Jin, Bolin ; Zhang, Enming LU ; Gong, Qiuhong and Zhou, Xianliang , et al. (2024) In Journal of Hazardous Materials 472.
Abstract

The relationship of ozone (O3), particularly the long-term exposure, with impacting metabolic homeostasis in population was understudied and under-recognised. Here, we used data from ChinaHEART, a nationwide, population-based cohort study, combined with O3 and PM2.5 concentration data with high spatiotemporal resolution, to explore the independent association of exposure to O3 with the prevalence of insulin resistance (IR). Among the 271 540 participants included, the crude prevalence of IR was 39.1%, while the age and sex standardized prevalence stood at 33.0%. Higher IR prevalence was observed with each increase of 10.0 μg/m3 in long-term O3 exposure, yielding adjusted... (More)

The relationship of ozone (O3), particularly the long-term exposure, with impacting metabolic homeostasis in population was understudied and under-recognised. Here, we used data from ChinaHEART, a nationwide, population-based cohort study, combined with O3 and PM2.5 concentration data with high spatiotemporal resolution, to explore the independent association of exposure to O3 with the prevalence of insulin resistance (IR). Among the 271 540 participants included, the crude prevalence of IR was 39.1%, while the age and sex standardized prevalence stood at 33.0%. Higher IR prevalence was observed with each increase of 10.0 μg/m3 in long-term O3 exposure, yielding adjusted odds ratios (OR) of 1.084 (95% CI: 1.079–1.089) in the one-pollutant model and 1.073 (95% CI: 1.067–1.079) in the two-pollutant model. Notably, a significant additive interaction between O3 and PM2.5 on the prevalence of IR was observed (P for additive interaction < 0.001). Our main findings remained consistent and robust in the sensitivity analyses. Our study suggests long-term exposure to O3 was independently and positively associated with prevalence of IR. It emphasized the benefits of policy interventions to reduce O3 and PM2.5 exposure jointly, which could ultimately alleviate the health and economic burden related to DM.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Airborne pollutants, Estimated glucose disposal rate, Insulin resistance, Long-term exposure, Ozone
in
Journal of Hazardous Materials
volume
472
article number
134504
publisher
Elsevier
external identifiers
  • pmid:38704910
  • scopus:85192108317
ISSN
0304-3894
DOI
10.1016/j.jhazmat.2024.134504
language
English
LU publication?
yes
id
a9c60d12-b1a9-4474-aab3-d025a1d25a35
date added to LUP
2024-05-20 12:38:32
date last changed
2024-06-17 14:15:02
@article{a9c60d12-b1a9-4474-aab3-d025a1d25a35,
  abstract     = {{<p>The relationship of ozone (O<sub>3</sub>), particularly the long-term exposure, with impacting metabolic homeostasis in population was understudied and under-recognised. Here, we used data from ChinaHEART, a nationwide, population-based cohort study, combined with O<sub>3</sub> and PM<sub>2.5</sub> concentration data with high spatiotemporal resolution, to explore the independent association of exposure to O<sub>3</sub> with the prevalence of insulin resistance (IR). Among the 271 540 participants included, the crude prevalence of IR was 39.1%, while the age and sex standardized prevalence stood at 33.0%. Higher IR prevalence was observed with each increase of 10.0 μg/m<sup>3</sup> in long-term O<sub>3</sub> exposure, yielding adjusted odds ratios (OR) of 1.084 (95% CI: 1.079–1.089) in the one-pollutant model and 1.073 (95% CI: 1.067–1.079) in the two-pollutant model. Notably, a significant additive interaction between O<sub>3</sub> and PM<sub>2.5</sub> on the prevalence of IR was observed (P for additive interaction &lt; 0.001). Our main findings remained consistent and robust in the sensitivity analyses. Our study suggests long-term exposure to O<sub>3</sub> was independently and positively associated with prevalence of IR. It emphasized the benefits of policy interventions to reduce O<sub>3</sub> and PM<sub>2.5</sub> exposure jointly, which could ultimately alleviate the health and economic burden related to DM.</p>}},
  author       = {{Zhang, Zenglei and Luan, Cheng and Wang, Chunqi and Li, Tiantian and Wu, Yi and Huang, Xin and Jin, Bolin and Zhang, Enming and Gong, Qiuhong and Zhou, Xianliang and Li, Xi}},
  issn         = {{0304-3894}},
  keywords     = {{Airborne pollutants; Estimated glucose disposal rate; Insulin resistance; Long-term exposure; Ozone}},
  language     = {{eng}},
  month        = {{07}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Hazardous Materials}},
  title        = {{Insulin resistance and its relationship with long-term exposure to ozone : Data based on a national population cohort}},
  url          = {{http://dx.doi.org/10.1016/j.jhazmat.2024.134504}},
  doi          = {{10.1016/j.jhazmat.2024.134504}},
  volume       = {{472}},
  year         = {{2024}},
}