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Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database

Ingegnoli, Francesca; Ardoino, Ilaria; Boracchi, Patrizia; Cutolo, Maurizio; Airo, Paolo; Ananieva, Lidia P.; Ancuta, Codrina; Andrade, Luis Eduardo; Becvar, Radim and Benenati, Alessia, et al. (2013) In Microvascular Research 89. p.122-128
Abstract
Objective: The aims of this study were to obtain cross-sectional data on capillaroscopy in an international multi-center cohort of Systemic Sclerosis (SSc) and to investigate the frequency of the capillaroscopic patterns and their disease-phenotype associations. Methods: Data collected between June 2004 and October 2011 in the EULAR Scleroderma Trials and Research (EUSTAR) registry were examined. Patients' profiles based on clinical and laboratory data were obtained by cluster analysis and the association between profiles and capillaroscopy was investigated by multinomial logistic regression. Results: 62 of the 110 EUSTAR centers entered data on capillaroscopy in the EUSTAR database. 376 of the 2754 patients (13.65%) were classified as... (More)
Objective: The aims of this study were to obtain cross-sectional data on capillaroscopy in an international multi-center cohort of Systemic Sclerosis (SSc) and to investigate the frequency of the capillaroscopic patterns and their disease-phenotype associations. Methods: Data collected between June 2004 and October 2011 in the EULAR Scleroderma Trials and Research (EUSTAR) registry were examined. Patients' profiles based on clinical and laboratory data were obtained by cluster analysis and the association between profiles and capillaroscopy was investigated by multinomial logistic regression. Results: 62 of the 110 EUSTAR centers entered data on capillaroscopy in the EUSTAR database. 376 of the 2754 patients (13.65%) were classified as scleroderma pattern absent, but non-specific capillary abnormalities were noted in 55.48% of the cases. Four major patients' profiles were identified characterized by a progressive severity for skin involvement, as well as an increased number of systemic manifestations. The "early" and "active" scleroderma patterns were generally observed in patients with mild/moderate skin involvement and a low number of disease manifestations, while the "late" scleroderma pattern was found more frequently in the more severe forms of the disease. Conclusion: These data indicate the importance of capillaroscopy in SSc management and that capillaroscopic patterns are directly related to the extent of organ involvement. (C) 2013 Elsevier Inc. All rights reserved. (Less)
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@article{a9cdca2e-9693-4a05-a2f7-1bc5abd8642c,
  abstract     = {Objective: The aims of this study were to obtain cross-sectional data on capillaroscopy in an international multi-center cohort of Systemic Sclerosis (SSc) and to investigate the frequency of the capillaroscopic patterns and their disease-phenotype associations. Methods: Data collected between June 2004 and October 2011 in the EULAR Scleroderma Trials and Research (EUSTAR) registry were examined. Patients' profiles based on clinical and laboratory data were obtained by cluster analysis and the association between profiles and capillaroscopy was investigated by multinomial logistic regression. Results: 62 of the 110 EUSTAR centers entered data on capillaroscopy in the EUSTAR database. 376 of the 2754 patients (13.65%) were classified as scleroderma pattern absent, but non-specific capillary abnormalities were noted in 55.48% of the cases. Four major patients' profiles were identified characterized by a progressive severity for skin involvement, as well as an increased number of systemic manifestations. The "early" and "active" scleroderma patterns were generally observed in patients with mild/moderate skin involvement and a low number of disease manifestations, while the "late" scleroderma pattern was found more frequently in the more severe forms of the disease. Conclusion: These data indicate the importance of capillaroscopy in SSc management and that capillaroscopic patterns are directly related to the extent of organ involvement. (C) 2013 Elsevier Inc. All rights reserved.},
  author       = {Ingegnoli, Francesca and Ardoino, Ilaria and Boracchi, Patrizia and Cutolo, Maurizio and Airo, Paolo and Ananieva, Lidia P. and Ancuta, Codrina and Andrade, Luis Eduardo and Becvar, Radim and Benenati, Alessia and Caramaschi, Paola and Carreira, Patricia E. and Cuomo, Giovanna and Damjanov, Nemanja and Distler, Oliver and Foti, Rosario and Guiducci, Serena and Hachulla, Eric and Highton, John and Kayser, Cristiane and Lubatti, Chiara and Cerinic, Marco Matucci and Meier, Florian and Meroni, Pier Luigi and Mihai, Carmen Marina and Morgiel, Ewa and Mueller-Ladner, Ulf and Loyo, Esthela and Ortiz, Vera and Riccieri, Valeria and Scheja, Agneta and Skacelova, Simona and Smith, Vanessa and Stamenkovic, Bojana and Stebbings, Simon and Stoica, Viktor and Sulli, Alberto and Szechinski, Jacek and Tyndall, Alan and Valentini, Gabriele and Walker, Ulrich and Zeni, Silvana and Zlatanovic, Maja},
  issn         = {1095-9319},
  language     = {eng},
  pages        = {122--128},
  publisher    = {Academic Press},
  series       = {Microvascular Research},
  title        = {Nailfold capillaroscopy in systemic sclerosis: Data from the EULAR scleroderma trials and research (EUSTAR) database},
  url          = {http://dx.doi.org/10.1016/j.mvr.2013.06.003},
  volume       = {89},
  year         = {2013},
}