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Effects of acute stress provocation on cortisol levels, zonulin and inflammatory markers in low- and high-stressed men

Linninge, Caroline LU ; Jönsson, Peter LU ; Bolinsson, Hans LU ; Önning, Gunilla LU ; Eriksson, Joakim LU ; Johansson, Gerd LU and Ahrné, Siv LU (2018) In Biological Psychology 138. p.48-55
Abstract

The virtual version of the Trier Social Stress Test (V-TSST) is an effective and standardized tool for social stress induction. This study aimed to examine gut permeability and physiological and inflammatory markers of reactivity to acute psychosocial stress. Forty young men were classified as high-stressed (HIGHS) or low-stressed (LOWS) according to the Shirom-Melamed Burnout Questionnaire. Cardiovascular reactivity and gut dysfunction were studied along with cortisol, zonulin and cytokines. Gut permeability was shown to be affected within one hour after the psychosocial stress induction, and shown to be dependent on age. Interleukin-6 increased with time, most pronounced at the end of the one-hour recovery after V-TSST, and was... (More)

The virtual version of the Trier Social Stress Test (V-TSST) is an effective and standardized tool for social stress induction. This study aimed to examine gut permeability and physiological and inflammatory markers of reactivity to acute psychosocial stress. Forty young men were classified as high-stressed (HIGHS) or low-stressed (LOWS) according to the Shirom-Melamed Burnout Questionnaire. Cardiovascular reactivity and gut dysfunction were studied along with cortisol, zonulin and cytokines. Gut permeability was shown to be affected within one hour after the psychosocial stress induction, and shown to be dependent on age. Interleukin-6 increased with time, most pronounced at the end of the one-hour recovery after V-TSST, and was positively correlated to age. HIGHS experienced more abdominal dysfunction compared to LOWS. In conclusion, this study is the first to show fluctuations in gut permeability after psychosocial stress induction. This was partly associated with changes in inflammatory markers.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gut permeability, HPA axis, Inflammatory markers, Psychosocial stress, TSST, Virtual reality
in
Biological Psychology
volume
138
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:85051826852
ISSN
0301-0511
DOI
10.1016/j.biopsycho.2018.08.013
language
English
LU publication?
yes
id
aa484055-933d-4d28-9613-c07145a58de6
date added to LUP
2018-09-06 11:13:58
date last changed
2019-03-19 03:58:54
@article{aa484055-933d-4d28-9613-c07145a58de6,
  abstract     = {<p>The virtual version of the Trier Social Stress Test (V-TSST) is an effective and standardized tool for social stress induction. This study aimed to examine gut permeability and physiological and inflammatory markers of reactivity to acute psychosocial stress. Forty young men were classified as high-stressed (HIGHS) or low-stressed (LOWS) according to the Shirom-Melamed Burnout Questionnaire. Cardiovascular reactivity and gut dysfunction were studied along with cortisol, zonulin and cytokines. Gut permeability was shown to be affected within one hour after the psychosocial stress induction, and shown to be dependent on age. Interleukin-6 increased with time, most pronounced at the end of the one-hour recovery after V-TSST, and was positively correlated to age. HIGHS experienced more abdominal dysfunction compared to LOWS. In conclusion, this study is the first to show fluctuations in gut permeability after psychosocial stress induction. This was partly associated with changes in inflammatory markers.</p>},
  author       = {Linninge, Caroline and Jönsson, Peter and Bolinsson, Hans and Önning, Gunilla and Eriksson, Joakim and Johansson, Gerd and Ahrné, Siv},
  issn         = {0301-0511},
  keyword      = {Gut permeability,HPA axis,Inflammatory markers,Psychosocial stress,TSST,Virtual reality},
  language     = {eng},
  month        = {10},
  pages        = {48--55},
  publisher    = {Elsevier},
  series       = {Biological Psychology},
  title        = {Effects of acute stress provocation on cortisol levels, zonulin and inflammatory markers in low- and high-stressed men},
  url          = {http://dx.doi.org/10.1016/j.biopsycho.2018.08.013},
  volume       = {138},
  year         = {2018},
}