Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent
(2018) In Molecular Nutrition & Food Research 62(3).- Abstract
Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10−7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058,... (More)
Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10−7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10−8) such that each serving of low-fat dairy was associated with 0.225 kg m−2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.
(Less)
- author
- organization
- publishing date
- 2018-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- body mass index, CHARGE consortium, dairy intake, genome-wide interaction study, meta-analysis
- in
- Molecular Nutrition & Food Research
- volume
- 62
- issue
- 3
- article number
- 1700347
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85041378879
- pmid:28941034
- ISSN
- 1613-4125
- DOI
- 10.1002/mnfr.201700347
- language
- English
- LU publication?
- yes
- id
- aa4c3f3c-9b75-46a3-ad41-76eb1d703038
- date added to LUP
- 2018-02-15 14:34:25
- date last changed
- 2025-01-08 05:08:47
@article{aa4c3f3c-9b75-46a3-ad41-76eb1d703038,
abstract = {{<p>Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10<sup>−7)</sup>, and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10<sup>−8)</sup> such that each serving of low-fat dairy was associated with 0.225 kg m<sup>−2</sup> lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.</p>}},
author = {{Smith, Caren E. and Follis, Jack L. and Dashti, Hassan S. and Tanaka, Toshiko and Graff, Mariaelisa and Fretts, Amanda M. and Kilpeläinen, Tuomas O. and Wojczynski, Mary K. and Richardson, Kris and Nalls, Mike A. and Schulz, Christina Alexandra and Liu, Yongmei and Frazier-Wood, Alexis C. and van Eekelen, Esther and Wang, Carol and de Vries, Paul S. and Mikkilä, Vera and Rohde, Rebecca and Psaty, Bruce M. and Hansen, Torben and Feitosa, Mary F. and Lai, Chao Qiang and Houston, Denise K. and Ferruci, Luigi and Ericson, Ulrika and Wang, Zhe and de Mutsert, Renée and Oddy, Wendy H. and de Jonge, Ester A.L. and Seppälä, Ilkka and Justice, Anne E. and Lemaitre, Rozenn N. and Sørensen, Thorkild I.A. and Province, Michael A. and Parnell, Laurence D. and Garcia, Melissa E. and Bandinelli, Stefania and Orho-Melander, Marju and Rich, Stephen S. and Rosendaal, Frits R. and Pennell, Craig E. and Kiefte-de Jong, Jessica C. and Kähönen, Mika and Young, Kristin L. and Pedersen, Oluf and Aslibekyan, Stella and Rotter, Jerome I. and Mook-Kanamori, Dennis O. and Zillikens, M. Carola and Raitakari, Olli T. and North, Kari E. and Overvad, Kim and Arnett, Donna K. and Hofman, Albert and Lehtimäki, Terho and Tjønneland, Anne and Uitterlinden, André G. and Rivadeneira, Fernando and Franco, Oscar H. and German, J. Bruce and Siscovick, David S. and Cupples, L. Adrienne and Ordovás, José M.}},
issn = {{1613-4125}},
keywords = {{body mass index; CHARGE consortium; dairy intake; genome-wide interaction study; meta-analysis}},
language = {{eng}},
month = {{02}},
number = {{3}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Molecular Nutrition & Food Research}},
title = {{Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent}},
url = {{http://dx.doi.org/10.1002/mnfr.201700347}},
doi = {{10.1002/mnfr.201700347}},
volume = {{62}},
year = {{2018}},
}