Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging

Stridh, Magne LU ; Dahlstrand, Ulf LU ; Naumovska, Magdalena LU ; Engelsberg, Karl LU ; Gesslein, Bodil LU ; Sheikh, Rafi LU orcid ; Merdasa, Aboma LU and Malmsjö, Malin LU (2024) In Orbit (London)
Abstract

PURPOSE: The gold standard for skin cancer diagnosis is surgical excisional biopsy and histopathological examination. Several non-invasive diagnostic techniques exist, although they have not yet translated into clinical use. This is a proof-of-concept study to assess the possibility of imaging an angiosarcoma in the periocular area.

METHODS: We use laser speckle, hyperspectral, and photoacoustic imaging to monitor blood perfusion and oxygen saturation, as well as the molecular composition of the tissue. The information obtained from each imaging modality was combined in order to yield a more comprehensive picture of the function, as well as molecular composition of a rapidly growing cutaneous angiosarcoma in the periocular... (More)

PURPOSE: The gold standard for skin cancer diagnosis is surgical excisional biopsy and histopathological examination. Several non-invasive diagnostic techniques exist, although they have not yet translated into clinical use. This is a proof-of-concept study to assess the possibility of imaging an angiosarcoma in the periocular area.

METHODS: We use laser speckle, hyperspectral, and photoacoustic imaging to monitor blood perfusion and oxygen saturation, as well as the molecular composition of the tissue. The information obtained from each imaging modality was combined in order to yield a more comprehensive picture of the function, as well as molecular composition of a rapidly growing cutaneous angiosarcoma in the periocular area.

RESULTS: We found an increase in perfusion coupled with a reduction in oxygen saturation in the angiosarcoma. We could also extract the molecular composition of the angiosarcoma at a depth, depicting both the oxygen saturation and highlighting the presence of connective tissue via collagen.

CONCLUSIONS: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Perfusion & oxygenation monitoring, hyperspectral imaging, laser speckle contrast imaging, Photoacoustic imaging, angiosarcoma
in
Orbit (London)
pages
11 pages
publisher
Informa Healthcare
external identifiers
  • scopus:85190467204
  • pmid:38591750
ISSN
0167-6830
DOI
10.1080/01676830.2024.2331718
language
English
LU publication?
yes
id
aab4c431-1352-4562-99b2-1f0d8551e1f8
date added to LUP
2024-04-10 22:32:09
date last changed
2024-04-29 08:42:16
@article{aab4c431-1352-4562-99b2-1f0d8551e1f8,
  abstract     = {{<p>PURPOSE: The gold standard for skin cancer diagnosis is surgical excisional biopsy and histopathological examination. Several non-invasive diagnostic techniques exist, although they have not yet translated into clinical use. This is a proof-of-concept study to assess the possibility of imaging an angiosarcoma in the periocular area.</p><p>METHODS: We use laser speckle, hyperspectral, and photoacoustic imaging to monitor blood perfusion and oxygen saturation, as well as the molecular composition of the tissue. The information obtained from each imaging modality was combined in order to yield a more comprehensive picture of the function, as well as molecular composition of a rapidly growing cutaneous angiosarcoma in the periocular area.</p><p>RESULTS: We found an increase in perfusion coupled with a reduction in oxygen saturation in the angiosarcoma. We could also extract the molecular composition of the angiosarcoma at a depth, depicting both the oxygen saturation and highlighting the presence of connective tissue via collagen.</p><p>CONCLUSIONS: We demonstrate the different physiological parameters that can be obtained with the different techniques and how these can be combined to provide detailed 3D maps of the functional and molecular properties of tumors useful in preoperative assessment.</p>}},
  author       = {{Stridh, Magne and Dahlstrand, Ulf and Naumovska, Magdalena and Engelsberg, Karl and Gesslein, Bodil and Sheikh, Rafi and Merdasa, Aboma and Malmsjö, Malin}},
  issn         = {{0167-6830}},
  keywords     = {{Perfusion & oxygenation monitoring; hyperspectral imaging; laser speckle contrast imaging; Photoacoustic imaging; angiosarcoma}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{Informa Healthcare}},
  series       = {{Orbit (London)}},
  title        = {{Functional and molecular 3D mapping of angiosarcoma tumor using non-invasive laser speckle, hyperspectral, and photoacoustic imaging}},
  url          = {{http://dx.doi.org/10.1080/01676830.2024.2331718}},
  doi          = {{10.1080/01676830.2024.2331718}},
  year         = {{2024}},
}