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Red cell sodium-potassium adenosine triphosphatase sites and intracellular sodium increased in obese school children

Flodmark, Carl-Erik LU ; Henningsen, N.C. and Sveger, T. (1992) In Mineral and Electrolyte Metabolism 18(1). p.6-8
Abstract
Principally to ascertain whether mineral metabolism is involved in weight regulation, the 40 most obese of 1,774 children, aged 10-11 years, screened for obesity were compared with 46 age-matched controls. The obese children had more 3H-Ouabain erythrocyte binding sites (p = 0.04), higher intracellular sodium (p = 0.04), and lower plasma sodium (p = 0.002). After exclusion of the non-Scandinavians, the p values were p = 0.02, p = 0.03, and p = 0.03, respectively. Analysis of variance also showed the differences to be more dependent on obesity than on gender or nationality. It is concluded that obese children have more 3H-Ouabain erythrocyte binding sites indicating an increase of the sodium-potassium adenosine triphosphatase activity. The... (More)
Principally to ascertain whether mineral metabolism is involved in weight regulation, the 40 most obese of 1,774 children, aged 10-11 years, screened for obesity were compared with 46 age-matched controls. The obese children had more 3H-Ouabain erythrocyte binding sites (p = 0.04), higher intracellular sodium (p = 0.04), and lower plasma sodium (p = 0.002). After exclusion of the non-Scandinavians, the p values were p = 0.02, p = 0.03, and p = 0.03, respectively. Analysis of variance also showed the differences to be more dependent on obesity than on gender or nationality. It is concluded that obese children have more 3H-Ouabain erythrocyte binding sites indicating an increase of the sodium-potassium adenosine triphosphatase activity. The increase of intracellular sodium may increase the risk of future hypertension. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mineral and Electrolyte Metabolism
volume
18
issue
1
pages
6 - 8
publisher
Karger
external identifiers
  • scopus:0026494091
ISSN
1423-016X
language
English
LU publication?
yes
id
aab89ce5-faae-4026-9d41-1f7b570c7d1d (old id 1106803)
date added to LUP
2016-04-01 11:52:58
date last changed
2025-10-14 12:10:30
@article{aab89ce5-faae-4026-9d41-1f7b570c7d1d,
  abstract     = {{Principally to ascertain whether mineral metabolism is involved in weight regulation, the 40 most obese of 1,774 children, aged 10-11 years, screened for obesity were compared with 46 age-matched controls. The obese children had more 3H-Ouabain erythrocyte binding sites (p = 0.04), higher intracellular sodium (p = 0.04), and lower plasma sodium (p = 0.002). After exclusion of the non-Scandinavians, the p values were p = 0.02, p = 0.03, and p = 0.03, respectively. Analysis of variance also showed the differences to be more dependent on obesity than on gender or nationality. It is concluded that obese children have more 3H-Ouabain erythrocyte binding sites indicating an increase of the sodium-potassium adenosine triphosphatase activity. The increase of intracellular sodium may increase the risk of future hypertension.}},
  author       = {{Flodmark, Carl-Erik and Henningsen, N.C. and Sveger, T.}},
  issn         = {{1423-016X}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{6--8}},
  publisher    = {{Karger}},
  series       = {{Mineral and Electrolyte Metabolism}},
  title        = {{Red cell sodium-potassium adenosine triphosphatase sites and intracellular sodium increased in obese school children}},
  volume       = {{18}},
  year         = {{1992}},
}