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4,4′-Thiobis(2-tert-butyl-5-methylphenol), an antioxidant in medical devices that may cause allergic contact dermatitis

Antelmi, Annarita LU ; Lejding, Tina LU orcid ; Bruze, Magnus LU ; Mowitz, Martin LU and Dahlin, Jakob LU (2023) In Contact Dermatitis 89(2). p.103-106
Abstract

Background: Antioxidants in medical devices, added to protect polymers or adhesives, may also cause contact dermatitis in some individuals. Objectives: To present data on sensitization to 4,4′-thiobis(2-tert-butyl-5-methylphenol), an antioxidant detected in some types of medical devices, for six patients that experienced eczematous reactions to different medical devices. Methods: Patch testing with 4,4′-thiobis(2-tert-butyl-5-methylphenol), 1% pet was performed. Gas chromatography-mass spectrometry (GC-MS) was used for identification of 4,4′-thiobis(2-tert-butyl-5-methylphenol) in different medical device products. Results: Six patients with contact allergy to 4,4′-thiobis(2-tert-butyl-5-methylphenol) also had relevant contact allergic... (More)

Background: Antioxidants in medical devices, added to protect polymers or adhesives, may also cause contact dermatitis in some individuals. Objectives: To present data on sensitization to 4,4′-thiobis(2-tert-butyl-5-methylphenol), an antioxidant detected in some types of medical devices, for six patients that experienced eczematous reactions to different medical devices. Methods: Patch testing with 4,4′-thiobis(2-tert-butyl-5-methylphenol), 1% pet was performed. Gas chromatography-mass spectrometry (GC-MS) was used for identification of 4,4′-thiobis(2-tert-butyl-5-methylphenol) in different medical device products. Results: Six patients with contact allergy to 4,4′-thiobis(2-tert-butyl-5-methylphenol) also had relevant contact allergic reactions to medical devices containing the antioxidant. The presence of the antioxidant in products was detected using GC-MS analysis. Conclusions: The antioxidant 4,4′-thiobis(2-tert-butyl-5-methylphenol) may cause allergic contact dermatitis after exposure to different medical devices.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antioxidant, CAS 96-69-5, contact dermatitis, EMLA, GC-MS, Kendall AMD, Lowinox, medical device, Santonox, Steri-strip, Tegaderm, wound care
in
Contact Dermatitis
volume
89
issue
2
pages
4 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:37194199
  • scopus:85159266975
ISSN
0105-1873
DOI
10.1111/cod.14335
language
English
LU publication?
yes
id
aadc9cab-29cf-4823-9011-5727069d5ae6
date added to LUP
2023-08-15 09:09:52
date last changed
2025-05-18 13:56:34
@article{aadc9cab-29cf-4823-9011-5727069d5ae6,
  abstract     = {{<p>Background: Antioxidants in medical devices, added to protect polymers or adhesives, may also cause contact dermatitis in some individuals. Objectives: To present data on sensitization to 4,4′-thiobis(2-tert-butyl-5-methylphenol), an antioxidant detected in some types of medical devices, for six patients that experienced eczematous reactions to different medical devices. Methods: Patch testing with 4,4′-thiobis(2-tert-butyl-5-methylphenol), 1% pet was performed. Gas chromatography-mass spectrometry (GC-MS) was used for identification of 4,4′-thiobis(2-tert-butyl-5-methylphenol) in different medical device products. Results: Six patients with contact allergy to 4,4′-thiobis(2-tert-butyl-5-methylphenol) also had relevant contact allergic reactions to medical devices containing the antioxidant. The presence of the antioxidant in products was detected using GC-MS analysis. Conclusions: The antioxidant 4,4′-thiobis(2-tert-butyl-5-methylphenol) may cause allergic contact dermatitis after exposure to different medical devices.</p>}},
  author       = {{Antelmi, Annarita and Lejding, Tina and Bruze, Magnus and Mowitz, Martin and Dahlin, Jakob}},
  issn         = {{0105-1873}},
  keywords     = {{antioxidant; CAS 96-69-5; contact dermatitis; EMLA; GC-MS; Kendall AMD; Lowinox; medical device; Santonox; Steri-strip; Tegaderm; wound care}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{103--106}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{4,4′-Thiobis(2-tert-butyl-5-methylphenol), an antioxidant in medical devices that may cause allergic contact dermatitis}},
  url          = {{http://dx.doi.org/10.1111/cod.14335}},
  doi          = {{10.1111/cod.14335}},
  volume       = {{89}},
  year         = {{2023}},
}