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Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study

Michaud, Dominique S. ; Izard, Jacques ; Rubin, Zachary ; Johansson, Ingegerd ; Weiderpass, Elisabete ; Tjonneland, Anne ; Olsen, Anja ; Overvad, Kim ; Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise , et al. (2013) In Cancer Causes and Control 24(11). p.1901-1909
Abstract
Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing... (More)
Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. IgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL; p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL). Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria. (Less)
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published
subject
keywords
Antibodies to oral bacteria, Smoking, Lifestyle factors
in
Cancer Causes and Control
volume
24
issue
11
pages
1901 - 1909
publisher
Springer
external identifiers
  • wos:000325942000001
  • scopus:84886784454
  • pmid:23901020
ISSN
1573-7225
DOI
10.1007/s10552-013-0265-2
language
English
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yes
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aaf80b9e-1ca7-43f8-89a9-658f5872029c (old id 4212594)
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2016-04-01 11:15:52
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2020-04-07 01:53:25
@article{aaf80b9e-1ca7-43f8-89a9-658f5872029c,
  abstract     = {Increasing evidence suggests that oral microbiota play a pivotal role in chronic diseases, in addition to the well-established role in periodontal disease. Moreover, recent studies suggest that oral bacteria may also be involved in carcinogenesis; periodontal disease has been linked to several cancers. In this study, we examined whether lifestyle factors have an impact on antibody levels to oral bacteria. Data on demographic characteristics, lifestyle factors, and medical conditions were obtained at the time of blood sample collection. For the current analysis, we measured antibody levels to 25 oral bacteria in 395 cancer-free individuals using an immunoblot array. Combined total immunoglobin G (IgG) levels were obtained by summing concentrations for all oral bacteria measured. IgG antibody levels were substantially lower among current and former smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960 ng/mL; p trend = 0.01), but did not vary by other factors, including body mass index, diabetes, physical activity, or by dietary factors, after adjusting for age, sex, education, country, and smoking status. The highest levels of total IgG were found among individuals with low education (2,419 ng/mL). Our findings on smoking are consistent with previous studies and support the notion that smokers have a compromised humoral immune response. Moreover, other major factors known to be associated with inflammatory markers, including obesity, were not associated with antibody levels to a large number of oral bacteria.},
  author       = {Michaud, Dominique S. and Izard, Jacques and Rubin, Zachary and Johansson, Ingegerd and Weiderpass, Elisabete and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise and Dossus, Laure and Kaaks, Rudolf and Katzke, Verena A. and Boeing, Heiner and Foerster, Jana and Trichopoulou, Antonia and Naska, Androniki and Ziara, Giana and Vineis, Paolo and Grioni, Sara and Palli, Domenico and Tumino, Rosario and Mattiello, Amalia and Peeters, Petra H. M. and Siersema, Peter D. and Barricarte, Aurelio and Huerta, Jose-Maria and Molina-Montes, Esther and Dorronsoro, Miren and Ramon Quiros, J. and Duell, Eric J. and Ohlsson, Bodil and Jeppsson, Bengt and Johansson, Anders and Lif, Pernilla and Khaw, Kay-Tee and Wareham, Nick and Travis, Ruth C. and Key, Tim J. and Freisling, Heinz and Duarte-Salles, Talita and Stepien, Magdalena and Riboli, Elio and Bueno-de-Mesquita, H. Bas},
  issn         = {1573-7225},
  language     = {eng},
  number       = {11},
  pages        = {1901--1909},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Lifestyle, dietary factors, and antibody levels to oral bacteria in cancer-free participants of a European cohort study},
  url          = {http://dx.doi.org/10.1007/s10552-013-0265-2},
  doi          = {10.1007/s10552-013-0265-2},
  volume       = {24},
  year         = {2013},
}