Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke
Santopolo, Giuseppe ; Magnusson, Jens P. ; Lindvall, Olle LU ; Kokaia, Zaal LU
and Frisén, Jonas
(2020)
In Cells
9(7).
- Abstract
Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activate neurogenesis by striatal astrocytes in the absence of an injury. Here we report that blocking Notch-signaling in stroke increases the neurogenic response to stroke 3.5-fold in mice. Deletion of Rbpj results in the recruitment of a larger number of parenchymal astrocytes to neurogenesis and over larger areas of the striatum. These data suggest... (More)
Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activate neurogenesis by striatal astrocytes in the absence of an injury. Here we report that blocking Notch-signaling in stroke increases the neurogenic response to stroke 3.5-fold in mice. Deletion of Rbpj results in the recruitment of a larger number of parenchymal astrocytes to neurogenesis and over larger areas of the striatum. These data suggest inhibition of Notch-signaling as a potential translational strategy to promote neuronal regeneration after stroke.
(Less)
- author
- Santopolo, Giuseppe
; Magnusson, Jens P.
; Lindvall, Olle
LU
; Kokaia, Zaal
LU
and Frisén, Jonas
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- astrocyte, neurogenesis, stem cell, striatum, stroke
- in
- Cells
- volume
- 9
- issue
- 7
- article number
- 1732
- publisher
- MDPI AG
- external identifiers
-
- pmid:32698472
- scopus:85088451635
- ISSN
- 2073-4409
- DOI
- 10.3390/cells9071732
- language
- English
- LU publication?
- yes
- id
- ab23c0b4-32f1-4f5a-84ad-788ffb5a273b
- date added to LUP
- 2020-08-04 11:07:50
- date last changed
- 2024-05-02 13:23:05
@article{ab23c0b4-32f1-4f5a-84ad-788ffb5a273b,
abstract = {{<p>Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activate neurogenesis by striatal astrocytes in the absence of an injury. Here we report that blocking Notch-signaling in stroke increases the neurogenic response to stroke 3.5-fold in mice. Deletion of Rbpj results in the recruitment of a larger number of parenchymal astrocytes to neurogenesis and over larger areas of the striatum. These data suggest inhibition of Notch-signaling as a potential translational strategy to promote neuronal regeneration after stroke.</p>}},
author = {{Santopolo, Giuseppe and Magnusson, Jens P. and Lindvall, Olle and Kokaia, Zaal and Frisén, Jonas}},
issn = {{2073-4409}},
keywords = {{astrocyte; neurogenesis; stem cell; striatum; stroke}},
language = {{eng}},
number = {{7}},
publisher = {{MDPI AG}},
series = {{Cells}},
title = {{Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke}},
url = {{http://dx.doi.org/10.3390/cells9071732}},
doi = {{10.3390/cells9071732}},
volume = {{9}},
year = {{2020}},
}