Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation.
(2007) In Seminars in Cancer Biology 17(3). p.248-256- Abstract
- Neuroblastoma is a childhood tumor derived from precursor or immature cells of the sympathetic nervous system. Neuroblastomas show a tremendous clinical heterogeneity, encompassing truly benign as well as extremely aggressive forms. In vivo as well as in vitro data have shown that the degree of sympathetic neuronal tumor cell differentiation influences patient outcome. Unraveling mechanisms governing neuroblastoma cell differentiation is therefore a central issue in the neuroblastoma research field. In this communication, we discuss some of the in vitro models frequently used to study human neuroblastoma cell differentiation. We also review recent data demonstrating that oxygen shortage, hypoxia, shifts neuroblastoma cells toward an... (More)
- Neuroblastoma is a childhood tumor derived from precursor or immature cells of the sympathetic nervous system. Neuroblastomas show a tremendous clinical heterogeneity, encompassing truly benign as well as extremely aggressive forms. In vivo as well as in vitro data have shown that the degree of sympathetic neuronal tumor cell differentiation influences patient outcome. Unraveling mechanisms governing neuroblastoma cell differentiation is therefore a central issue in the neuroblastoma research field. In this communication, we discuss some of the in vitro models frequently used to study human neuroblastoma cell differentiation. We also review recent data demonstrating that oxygen shortage, hypoxia, shifts neuroblastoma cells toward an immature, stem cell-like phenotype and discuss the potential clinical impact of hypoxia on neuroblastoma behavior. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/159109
- author
- Edsjö, Anders LU ; Holmquist Mengelbier, Linda LU and Påhlman, Sven LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- neuroblastoma, hypoxia, sympathetic nervous, neuronal differentiation, system
- in
- Seminars in Cancer Biology
- volume
- 17
- issue
- 3
- pages
- 248 - 256
- publisher
- Academic Press
- external identifiers
-
- wos:000246860300009
- scopus:33947138135
- ISSN
- 1096-3650
- DOI
- 10.1016/j.semcancer.2006.04.005
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular Medicine (013031200)
- id
- ab56c19f-e2d1-4618-86a6-442cdeee9d47 (old id 159109)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16828305&dopt=Abstract
- date added to LUP
- 2016-04-01 16:24:32
- date last changed
- 2022-03-22 18:32:14
@article{ab56c19f-e2d1-4618-86a6-442cdeee9d47,
abstract = {{Neuroblastoma is a childhood tumor derived from precursor or immature cells of the sympathetic nervous system. Neuroblastomas show a tremendous clinical heterogeneity, encompassing truly benign as well as extremely aggressive forms. In vivo as well as in vitro data have shown that the degree of sympathetic neuronal tumor cell differentiation influences patient outcome. Unraveling mechanisms governing neuroblastoma cell differentiation is therefore a central issue in the neuroblastoma research field. In this communication, we discuss some of the in vitro models frequently used to study human neuroblastoma cell differentiation. We also review recent data demonstrating that oxygen shortage, hypoxia, shifts neuroblastoma cells toward an immature, stem cell-like phenotype and discuss the potential clinical impact of hypoxia on neuroblastoma behavior.}},
author = {{Edsjö, Anders and Holmquist Mengelbier, Linda and Påhlman, Sven}},
issn = {{1096-3650}},
keywords = {{neuroblastoma; hypoxia; sympathetic nervous; neuronal differentiation; system}},
language = {{eng}},
number = {{3}},
pages = {{248--256}},
publisher = {{Academic Press}},
series = {{Seminars in Cancer Biology}},
title = {{Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation.}},
url = {{http://dx.doi.org/10.1016/j.semcancer.2006.04.005}},
doi = {{10.1016/j.semcancer.2006.04.005}},
volume = {{17}},
year = {{2007}},
}