Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype
Janelidze, Shorena LU ; Hertze, Joakim LU ; Nägga, Katarina LU ; Nilsson, Karin ; Nilsson, Christer LU ; Wennström, Malin LU ; van Westen, Danielle LU
; Blennow, Kaj
LU
; Zetterberg, Henrik
LU
and Hansson, Oskar
LU
(2017)
In Neurobiology of Aging
51.
p.104-112
- Abstract
Blood-brain barrier (BBB) dysfunction might be an important component of many neurodegenerative disorders. In this study, we investigated its role in dementia using large clinical cohorts. The cerebrospinal fluid (CSF)/plasma albumin ratio (Qalb), an indicator of BBB (and blood-CSF barrier) permeability, was measured in a total of 1015 individuals. The ratio was increased in patients with Alzheimer's disease, dementia with Lewy bodies or Parkinson's disease dementia, subcortical vascular dementia, and frontotemporal dementia compared with controls. However, this measure was not changed during preclinical or prodromal Alzheimer's disease and was not associated with amyloid positron emission tomography or APOE genotype. The Qalb was... (More)
Blood-brain barrier (BBB) dysfunction might be an important component of many neurodegenerative disorders. In this study, we investigated its role in dementia using large clinical cohorts. The cerebrospinal fluid (CSF)/plasma albumin ratio (Qalb), an indicator of BBB (and blood-CSF barrier) permeability, was measured in a total of 1015 individuals. The ratio was increased in patients with Alzheimer's disease, dementia with Lewy bodies or Parkinson's disease dementia, subcortical vascular dementia, and frontotemporal dementia compared with controls. However, this measure was not changed during preclinical or prodromal Alzheimer's disease and was not associated with amyloid positron emission tomography or APOE genotype. The Qalb was increased in diabetes mellitus and correlated positively with CSF biomarkers of angiogenesis and endothelial dysfunction (vascular endothelial growth factor, intracellular adhesion molecule 1, and vascular cell adhesion molecule 1). In healthy elderly, high body mass index and waist-hip ratio predicted increased Qalb 20 years later. In summary, BBB permeability is increased in major dementia disorders but does not relate to amyloid pathology or APOE genotype. Instead, BBB impairment may be associated with diabetes and brain microvascular damage.
(Less)
- author
- Janelidze, Shorena
LU
; Hertze, Joakim
LU
; Nägga, Katarina
LU
; Nilsson, Karin
; Nilsson, Christer
LU
; Wennström, Malin
LU
; van Westen, Danielle
LU
; Blennow, Kaj
LU
; Zetterberg, Henrik
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2017-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Amyloid, APOE ε4, Blood-brain barrier, Dementia, Diabetes, Vascular pathology
- in
- Neurobiology of Aging
- volume
- 51
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:28061383
- wos:000397168600011
- scopus:85007609372
- ISSN
- 0197-4580
- DOI
- 10.1016/j.neurobiolaging.2016.11.017
- language
- English
- LU publication?
- yes
- id
- ab5978cb-ead1-41d4-a770-debde7f827a6
- date added to LUP
- 2017-01-13 11:38:15
- date last changed
- 2025-01-12 19:25:34
@article{ab5978cb-ead1-41d4-a770-debde7f827a6,
abstract = {{<p>Blood-brain barrier (BBB) dysfunction might be an important component of many neurodegenerative disorders. In this study, we investigated its role in dementia using large clinical cohorts. The cerebrospinal fluid (CSF)/plasma albumin ratio (Qalb), an indicator of BBB (and blood-CSF barrier) permeability, was measured in a total of 1015 individuals. The ratio was increased in patients with Alzheimer's disease, dementia with Lewy bodies or Parkinson's disease dementia, subcortical vascular dementia, and frontotemporal dementia compared with controls. However, this measure was not changed during preclinical or prodromal Alzheimer's disease and was not associated with amyloid positron emission tomography or APOE genotype. The Qalb was increased in diabetes mellitus and correlated positively with CSF biomarkers of angiogenesis and endothelial dysfunction (vascular endothelial growth factor, intracellular adhesion molecule 1, and vascular cell adhesion molecule 1). In healthy elderly, high body mass index and waist-hip ratio predicted increased Qalb 20 years later. In summary, BBB permeability is increased in major dementia disorders but does not relate to amyloid pathology or APOE genotype. Instead, BBB impairment may be associated with diabetes and brain microvascular damage.</p>}},
author = {{Janelidze, Shorena and Hertze, Joakim and Nägga, Katarina and Nilsson, Karin and Nilsson, Christer and Wennström, Malin and van Westen, Danielle and Blennow, Kaj and Zetterberg, Henrik and Hansson, Oskar}},
issn = {{0197-4580}},
keywords = {{Amyloid; APOE ε4; Blood-brain barrier; Dementia; Diabetes; Vascular pathology}},
language = {{eng}},
month = {{03}},
pages = {{104--112}},
publisher = {{Elsevier}},
series = {{Neurobiology of Aging}},
title = {{Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype}},
url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2016.11.017}},
doi = {{10.1016/j.neurobiolaging.2016.11.017}},
volume = {{51}},
year = {{2017}},
}