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Human immunoglobulin G levels of viruses and associated glioma risk

Sjostrom, Sara ; Hjalmars, Ulf ; Juto, Per ; Wadell, Goran ; Hallmans, Goran ; Tjonneland, Anne ; Halkjaer, Jytte ; Manjer, Jonas LU ; Almquist, Martin LU and Melin, Beatrice S. (2011) In Cancer Causes and Control 22(9). p.1259-1266
Abstract
Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated pre-diagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including... (More)
Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated pre-diagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including the nuclear antigen (EBNA1) using plasma samples from 197 cases of adult glioma and 394 controls collected from population-based cohorts in Sweden and Denmark. Low VZV IgG levels were marginally significantly more common in glioma cases than the controls (odds ratio (OR) = 0.68, 95% CI 0.41-1.13) for the fourth compared with the first quartile (p = 0.06 for trend). These results were more prominent when analyzing cases with blood sampling at least 2 years before diagnosis (OR = 0.63, 95% CI 0.37-1.08) (p = 0.03). No association with glioma risk was observed for CMV, EBV, and adenovirus. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glioma, Glioblastoma, Immunoglobulin G, Virus, Case-control study
in
Cancer Causes and Control
volume
22
issue
9
pages
1259 - 1266
publisher
Springer
external identifiers
  • wos:000293296200004
  • scopus:80052306232
ISSN
1573-7225
DOI
10.1007/s10552-011-9799-3
language
English
LU publication?
yes
id
ab5be44c-e4cc-48af-aa94-7768a8943bac (old id 2072397)
date added to LUP
2016-04-01 10:30:22
date last changed
2025-04-04 14:49:40
@article{ab5be44c-e4cc-48af-aa94-7768a8943bac,
  abstract     = {{Few consistent etiological factors have been identified for primary brain tumors. Inverse associations to asthma and low levels of varicella-zoster virus, immunoglobulin (Ig) levels in prevalent cases have indicted a role for the immune system in the development of glioma. Because samples from prevalent cases of glioma could be influenced by treatments such as steroids and chemotherapy, we investigated pre-diagnostic samples from three large Scandinavian cohorts. To test the hypothesis that immune response levels to these viruses are associated etiologically with glioma risk, we investigated pre-diagnostic immunoglobulin levels for cytomegalovirus (CMV), varicella-zoster virus (VZV), adenovirus (Ad), and Epstein-Barr virus (EBV) including the nuclear antigen (EBNA1) using plasma samples from 197 cases of adult glioma and 394 controls collected from population-based cohorts in Sweden and Denmark. Low VZV IgG levels were marginally significantly more common in glioma cases than the controls (odds ratio (OR) = 0.68, 95% CI 0.41-1.13) for the fourth compared with the first quartile (p = 0.06 for trend). These results were more prominent when analyzing cases with blood sampling at least 2 years before diagnosis (OR = 0.63, 95% CI 0.37-1.08) (p = 0.03). No association with glioma risk was observed for CMV, EBV, and adenovirus.}},
  author       = {{Sjostrom, Sara and Hjalmars, Ulf and Juto, Per and Wadell, Goran and Hallmans, Goran and Tjonneland, Anne and Halkjaer, Jytte and Manjer, Jonas and Almquist, Martin and Melin, Beatrice S.}},
  issn         = {{1573-7225}},
  keywords     = {{Glioma; Glioblastoma; Immunoglobulin G; Virus; Case-control study}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1259--1266}},
  publisher    = {{Springer}},
  series       = {{Cancer Causes and Control}},
  title        = {{Human immunoglobulin G levels of viruses and associated glioma risk}},
  url          = {{http://dx.doi.org/10.1007/s10552-011-9799-3}},
  doi          = {{10.1007/s10552-011-9799-3}},
  volume       = {{22}},
  year         = {{2011}},
}