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Inhibition of Fast Axonal Transport by erythro‐9‐[3‐(2‐Hydroxynonyl)]Adenine

Ekström, Per LU and Kanje, Martin LU (1984) In Journal of Neurochemistry 43(5). p.1342-1345
Abstract

Abstract: erythro‐9‐[3‐(2‐Hydroxynonyl)]adenine, an inhibitor of protein carboxylmethylation and dynein‐ATPase activity, inhibited fast axonal transport in vitro in frog sciatic nerves. Its site of action might be associated with an ATPase on which transport depends, since specific carboxylmethylation inhibitors lacked effects on transport. The levels of high energy phosphates and protein synthesis were unaffected by the drug at a transport‐inhibiting concentration, making disturbances due to metabolic effects less likely. An erythro‐9‐[3‐(2‐hy‐droxynonyl)]adenine‐sensitive ATPase was looked for in various nerve fractions but has so far not been resolved.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ATP‐ases, Axonal transport, EHNA
in
Journal of Neurochemistry
volume
43
issue
5
pages
4 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:0021691112
ISSN
0022-3042
DOI
10.1111/j.1471-4159.1984.tb05392.x
language
English
LU publication?
yes
id
ab6200b7-cb63-4ed6-9502-7606f1668741
date added to LUP
2016-12-07 14:24:06
date last changed
2017-02-26 04:43:36
@article{ab6200b7-cb63-4ed6-9502-7606f1668741,
  abstract     = {<p>Abstract:   erythro‐9‐[3‐(2‐Hydroxynonyl)]adenine, an inhibitor of protein carboxylmethylation and dynein‐ATPase activity, inhibited fast axonal transport in vitro in frog sciatic nerves. Its site of action might be associated with an ATPase on which transport depends, since specific carboxylmethylation inhibitors lacked effects on transport. The levels of high energy phosphates and protein synthesis were unaffected by the drug at a transport‐inhibiting concentration, making disturbances due to metabolic effects less likely. An erythro‐9‐[3‐(2‐hy‐droxynonyl)]adenine‐sensitive ATPase was looked for in various nerve fractions but has so far not been resolved.</p>},
  author       = {Ekström, Per and Kanje, Martin},
  issn         = {0022-3042},
  keyword      = {ATP‐ases,Axonal transport,EHNA},
  language     = {eng},
  number       = {5},
  pages        = {1342--1345},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Neurochemistry},
  title        = {Inhibition of Fast Axonal Transport by erythro‐9‐[3‐(2‐Hydroxynonyl)]Adenine},
  url          = {http://dx.doi.org/10.1111/j.1471-4159.1984.tb05392.x},
  volume       = {43},
  year         = {1984},
}