Advanced

Microproteinuria Predicts Organ Failure in Patients Presenting with Acute Pancreatitis

Bertilsson, Sara LU ; Swärd, Per LU ; Håkansson, Anders LU ; Tofik, Rafid LU ; Rippe, Bengt LU and Kalaitzakis, Evangelos LU (2016) In Digestive Diseases and Sciences 61(12). p.3592-3601
Abstract

BACKGROUND AND AIMS: The disease course of acute pancreatitis (AP) ranges from mild and self-limiting to severe inflammation, associated with significant morbidity and mortality. At present, there are no universally accepted and reliable predictors for severity. Microproteinuria has been associated with the presence of systemic inflammatory response syndrome as well as trauma, although its association with AP is not well understood. The aim of this study was to investigate the value of microproteinuria to predict development of organ failure in AP.

METHODS: Consecutive AP patients were prospectively enrolled. Urine samples were collected upon admission, 12-24 h after admission, and 3 months post-discharge for calculation of urine... (More)

BACKGROUND AND AIMS: The disease course of acute pancreatitis (AP) ranges from mild and self-limiting to severe inflammation, associated with significant morbidity and mortality. At present, there are no universally accepted and reliable predictors for severity. Microproteinuria has been associated with the presence of systemic inflammatory response syndrome as well as trauma, although its association with AP is not well understood. The aim of this study was to investigate the value of microproteinuria to predict development of organ failure in AP.

METHODS: Consecutive AP patients were prospectively enrolled. Urine samples were collected upon admission, 12-24 h after admission, and 3 months post-discharge for calculation of urine α1-microglobulin-, albumin-, IgG-, and IgM/creatinine ratios. Data regarding AP etiology, severity, and development of organ failure were registered.

RESULTS: Overall, 92 AP patients were included (14 % with organ failure; 6 % with severe AP). The α1-microglobulin-, albumin-, and IgG/creatinine ratios correlated with high-sensitivity C-reactive protein 48 h after admission (r = 0.47-0.61, p < 0.001 for all). They were also significantly higher in patients with versus without organ failure (p < 0.05 for all). The α1-microglobulin/creatinine ratio upon admission predicted organ failure [adjusted odds ratio 1.286, 95 % confidence interval (CI) 1.024-1.614] with similar accuracy (AUROC 0.81, 95 % CI 0.69-0.94) as the more complex APACHE II score (AUROC 0.86, 95 % CI 0.70-1.00).

CONCLUSION: The α1-microglobulin/creatinine ratio upon presentation with AP is related to inflammation and predicts development of organ failure. Further studies are warranted to evaluate its potential usefulness in predicting outcome for AP patients.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Digestive Diseases and Sciences
volume
61
issue
12
pages
3592 - 3601
publisher
Springer
external identifiers
  • scopus:84991063116
  • wos:000388227400031
ISSN
1573-2568
DOI
10.1007/s10620-016-4335-7
language
English
LU publication?
yes
id
ab76d76c-eca1-47fe-ba0b-21b7cc2f1814
date added to LUP
2016-10-27 13:21:53
date last changed
2017-09-18 11:28:27
@article{ab76d76c-eca1-47fe-ba0b-21b7cc2f1814,
  abstract     = {<p>BACKGROUND AND AIMS: The disease course of acute pancreatitis (AP) ranges from mild and self-limiting to severe inflammation, associated with significant morbidity and mortality. At present, there are no universally accepted and reliable predictors for severity. Microproteinuria has been associated with the presence of systemic inflammatory response syndrome as well as trauma, although its association with AP is not well understood. The aim of this study was to investigate the value of microproteinuria to predict development of organ failure in AP.</p><p>METHODS: Consecutive AP patients were prospectively enrolled. Urine samples were collected upon admission, 12-24 h after admission, and 3 months post-discharge for calculation of urine α1-microglobulin-, albumin-, IgG-, and IgM/creatinine ratios. Data regarding AP etiology, severity, and development of organ failure were registered.</p><p>RESULTS: Overall, 92 AP patients were included (14 % with organ failure; 6 % with severe AP). The α1-microglobulin-, albumin-, and IgG/creatinine ratios correlated with high-sensitivity C-reactive protein 48 h after admission (r = 0.47-0.61, p &lt; 0.001 for all). They were also significantly higher in patients with versus without organ failure (p &lt; 0.05 for all). The α1-microglobulin/creatinine ratio upon admission predicted organ failure [adjusted odds ratio 1.286, 95 % confidence interval (CI) 1.024-1.614] with similar accuracy (AUROC 0.81, 95 % CI 0.69-0.94) as the more complex APACHE II score (AUROC 0.86, 95 % CI 0.70-1.00).</p><p>CONCLUSION: The α1-microglobulin/creatinine ratio upon presentation with AP is related to inflammation and predicts development of organ failure. Further studies are warranted to evaluate its potential usefulness in predicting outcome for AP patients.</p>},
  author       = {Bertilsson, Sara and Swärd, Per and Håkansson, Anders and Tofik, Rafid and Rippe, Bengt and Kalaitzakis, Evangelos},
  issn         = {1573-2568},
  language     = {eng},
  number       = {12},
  pages        = {3592--3601},
  publisher    = {Springer},
  series       = {Digestive Diseases and Sciences},
  title        = {Microproteinuria Predicts Organ Failure in Patients Presenting with Acute Pancreatitis},
  url          = {http://dx.doi.org/10.1007/s10620-016-4335-7},
  volume       = {61},
  year         = {2016},
}