Cognitively normal women with Alzheimer's disease proteinopathy show relative preservation of memory but not of hippocampal volume
Caldwell, Jessica Z.K. ; Cummings, Jeffrey L. ; Banks, Sarah J. ; Palmqvist, Sebastian LU
and Hansson, Oskar
LU
(2019)
In Alzheimer's Research & Therapy
11(1).
- Abstract
BACKGROUND: We examined interactive effects of sex, diagnosis, and cerebrospinal fluid (CSF) amyloid beta/phosphorylated tau ratio (Aβ/P-tau) on verbal memory and hippocampal volumes. METHODS: We assessed 682 participants (350 women) from BioFINDER (250 cognitively normal [CN]; and 432 symptomatic: 186 subjective cognitive decline [SCD], 246 mild cognitive impairment [MCI]). General linear models evaluated effects of Alzheimer's disease (AD) proteinopathy (CSF Aß/p-tau ratio), diagnosis, and sex on verbal memory (ADAS-cog 10-word recall), semantic fluency (animal naming fluency), visuospatial skills (cube copy), processing speed/attention functions (Symbol Digit Modalities Test and Trail Making Part A), and hippocampal volumes. RESULTS:... (More)
BACKGROUND: We examined interactive effects of sex, diagnosis, and cerebrospinal fluid (CSF) amyloid beta/phosphorylated tau ratio (Aβ/P-tau) on verbal memory and hippocampal volumes. METHODS: We assessed 682 participants (350 women) from BioFINDER (250 cognitively normal [CN]; and 432 symptomatic: 186 subjective cognitive decline [SCD], 246 mild cognitive impairment [MCI]). General linear models evaluated effects of Alzheimer's disease (AD) proteinopathy (CSF Aß/p-tau ratio), diagnosis, and sex on verbal memory (ADAS-cog 10-word recall), semantic fluency (animal naming fluency), visuospatial skills (cube copy), processing speed/attention functions (Symbol Digit Modalities Test and Trail Making Part A), and hippocampal volumes. RESULTS: Amyloid-positive (Aβ/P-tau+) CN women (women with preclinical AD) showed memory equivalent to amyloid-negative (Aβ/P-tau-) CN women. In contrast, Aβ/P-tau+ CN men (men with preclinical AD) showed poorer memory than Aβ/P-tau- CN men. Symptomatic groups showed no sex differences in effect of AD proteinopathy on memory. There was no interactive effect of sex, diagnosis, and Aβ/P-tau on other measures of cognition or on hippocampal volume. CONCLUSIONS: CN women show relatively preserved verbal memory, but not general cognitive reserve or preserved hippocampal volume in the presence of Aβ/P-tau+. Results have implications for diagnosing AD in women, and for clinical trials.
(Less)
- author
- Caldwell, Jessica Z.K.
; Cummings, Jeffrey L.
; Banks, Sarah J.
; Palmqvist, Sebastian
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2019-12-26
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Hippocampus, Mild cognitive impairment, Sex, Subjective cognitive decline, Verbal memory, Women
- in
- Alzheimer's Research & Therapy
- volume
- 11
- issue
- 1
- article number
- 109
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85077252729
- pmid:31878968
- ISSN
- 1758-9193
- DOI
- 10.1186/s13195-019-0565-1
- language
- English
- LU publication?
- yes
- id
- ab7e670f-6851-4baf-aefc-aec7d160accf
- date added to LUP
- 2020-01-10 12:30:06
- date last changed
- 2024-05-29 06:55:15
@article{ab7e670f-6851-4baf-aefc-aec7d160accf,
abstract = {{<p>BACKGROUND: We examined interactive effects of sex, diagnosis, and cerebrospinal fluid (CSF) amyloid beta/phosphorylated tau ratio (Aβ/P-tau) on verbal memory and hippocampal volumes. METHODS: We assessed 682 participants (350 women) from BioFINDER (250 cognitively normal [CN]; and 432 symptomatic: 186 subjective cognitive decline [SCD], 246 mild cognitive impairment [MCI]). General linear models evaluated effects of Alzheimer's disease (AD) proteinopathy (CSF Aß/p-tau ratio), diagnosis, and sex on verbal memory (ADAS-cog 10-word recall), semantic fluency (animal naming fluency), visuospatial skills (cube copy), processing speed/attention functions (Symbol Digit Modalities Test and Trail Making Part A), and hippocampal volumes. RESULTS: Amyloid-positive (Aβ/P-tau+) CN women (women with preclinical AD) showed memory equivalent to amyloid-negative (Aβ/P-tau-) CN women. In contrast, Aβ/P-tau+ CN men (men with preclinical AD) showed poorer memory than Aβ/P-tau- CN men. Symptomatic groups showed no sex differences in effect of AD proteinopathy on memory. There was no interactive effect of sex, diagnosis, and Aβ/P-tau on other measures of cognition or on hippocampal volume. CONCLUSIONS: CN women show relatively preserved verbal memory, but not general cognitive reserve or preserved hippocampal volume in the presence of Aβ/P-tau+. Results have implications for diagnosing AD in women, and for clinical trials.</p>}},
author = {{Caldwell, Jessica Z.K. and Cummings, Jeffrey L. and Banks, Sarah J. and Palmqvist, Sebastian and Hansson, Oskar}},
issn = {{1758-9193}},
keywords = {{Hippocampus; Mild cognitive impairment; Sex; Subjective cognitive decline; Verbal memory; Women}},
language = {{eng}},
month = {{12}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Alzheimer's Research & Therapy}},
title = {{Cognitively normal women with Alzheimer's disease proteinopathy show relative preservation of memory but not of hippocampal volume}},
url = {{http://dx.doi.org/10.1186/s13195-019-0565-1}},
doi = {{10.1186/s13195-019-0565-1}},
volume = {{11}},
year = {{2019}},
}