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RIFM fragrance ingredient safety assessment, butyl 10-undecenoate, CAS Registry Number 109-42-2

Api, A. M. ; Belsito, D. ; Botelho, D. ; Bruze, M. LU ; Burton, G. A. ; Buschmann, J. ; Dagli, M. L. ; Date, M. ; Dekant, W. and Deodhar, C. , et al. (2019) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 130(Suppl. 1).
Abstract

Butyl 10-undecenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not expected to be genotoxic. Data on butyl 10-undecenoate and read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not a safety concern under the current, declared levels of use for the skin sensitization endpoint. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to butyl 10-undecenoate is... (More)

Butyl 10-undecenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not expected to be genotoxic. Data on butyl 10-undecenoate and read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not a safety concern under the current, declared levels of use for the skin sensitization endpoint. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to butyl 10-undecenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; butyl 10-undecenoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; butyl 10-undecenoate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
volume
130
issue
Suppl. 1
article number
110619
publisher
Elsevier
external identifiers
  • scopus:85070181422
  • pmid:31233879
ISSN
1873-6351
DOI
10.1016/j.fct.2019.110619
language
English
LU publication?
no
id
ab9250e6-146c-40ee-90f2-bf822d4994ad
date added to LUP
2019-09-05 13:53:54
date last changed
2024-06-26 01:54:35
@article{ab9250e6-146c-40ee-90f2-bf822d4994ad,
  abstract     = {{<p>Butyl 10-undecenoate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not expected to be genotoxic. Data on butyl 10-undecenoate and read-across analog methyl undec-10-enoate (CAS # 111-81-9) show that butyl 10-undecenoate is not a safety concern under the current, declared levels of use for the skin sensitization endpoint. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class I material, and the exposure to butyl 10-undecenoate is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; butyl 10-undecenoate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; butyl 10-undecenoate was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are &lt;1.</p>}},
  author       = {{Api, A. M. and Belsito, D. and Botelho, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Francis, M. and Fryer, A. D. and Jones, L. and Joshi, K. and La Cava, S. and Lapczynski, A. and Liebler, D. C. and O'Brien, D. and Patel, A. and Penning, T. M. and Ritacco, G. and Romine, J. and Sadekar, N. and Salvito, D. and Schultz, T. W. and Sipes, I. G. and Sullivan, G. and Thakkar, Y. and Tokura, Y. and Tsang, S.}},
  issn         = {{1873-6351}},
  language     = {{eng}},
  number       = {{Suppl. 1}},
  publisher    = {{Elsevier}},
  series       = {{Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association}},
  title        = {{RIFM fragrance ingredient safety assessment, butyl 10-undecenoate, CAS Registry Number 109-42-2}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2019.110619}},
  doi          = {{10.1016/j.fct.2019.110619}},
  volume       = {{130}},
  year         = {{2019}},
}