Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

A Swedish population-based study to evaluate the usefulness of resting heart rate in the prediction of suicidal behavior among males

Lannoy, Séverine ; Ohlsson, Henrik LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Edwards, Alexis C. (2024) In Suicide and Life-Threatening Behavior
Abstract

Introduction: Resting heart rate has been distinctly related to both internalizing (high pulse) and externalizing (low pulse) disorders. We aimed to explore the associations between resting heart rate and suicidal behavior (nonfatal suicide attempt [SA] and suicide death [SD]) and evaluate if such associations exist beyond the effects of internalizing/externalizing symptomatology. Method: We used Cox proportional hazards models to evaluate the associations between resting heart rate (age 19) and later SA/SD in 357,290 Swedish men. Models were controlled for internalizing disorders, externalizing disorders, and resilience (the ability to deal with adversity). Co-relative analysis (comparing pairs of different genetic relatedness) was... (More)

Introduction: Resting heart rate has been distinctly related to both internalizing (high pulse) and externalizing (low pulse) disorders. We aimed to explore the associations between resting heart rate and suicidal behavior (nonfatal suicide attempt [SA] and suicide death [SD]) and evaluate if such associations exist beyond the effects of internalizing/externalizing symptomatology. Method: We used Cox proportional hazards models to evaluate the associations between resting heart rate (age 19) and later SA/SD in 357,290 Swedish men. Models were controlled for internalizing disorders, externalizing disorders, and resilience (the ability to deal with adversity). Co-relative analysis (comparing pairs of different genetic relatedness) was used to control for unmeasured family confounders and improve causal inference. Results: In baseline models, low resting heart rate was associated with SA (HR = 0.96; 95% CI: 0.95,0.98) and high resting heart rate with SD (HR = 1.04; 95% CI: 1.002,1.07). The association with SA remained after adjustment for all confounders (HR = 0.98). However, the association with SD did not persist after controlling for covariates. Co-relative analysis did not support causal associations. Conclusions: Our findings raise interesting etiological questions for the understanding of suicidal behaviors but do not support the usefulness of resting heart rate in suicide prediction.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
death, pulse, resilience, suicide attempt
in
Suicide and Life-Threatening Behavior
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:38554058
  • scopus:85189621940
ISSN
0363-0234
DOI
10.1111/sltb.13077
language
English
LU publication?
yes
id
abc1bec1-2f35-402f-a0aa-68a41ca7a7db
date added to LUP
2024-04-25 13:18:59
date last changed
2024-06-20 18:29:14
@article{abc1bec1-2f35-402f-a0aa-68a41ca7a7db,
  abstract     = {{<p>Introduction: Resting heart rate has been distinctly related to both internalizing (high pulse) and externalizing (low pulse) disorders. We aimed to explore the associations between resting heart rate and suicidal behavior (nonfatal suicide attempt [SA] and suicide death [SD]) and evaluate if such associations exist beyond the effects of internalizing/externalizing symptomatology. Method: We used Cox proportional hazards models to evaluate the associations between resting heart rate (age 19) and later SA/SD in 357,290 Swedish men. Models were controlled for internalizing disorders, externalizing disorders, and resilience (the ability to deal with adversity). Co-relative analysis (comparing pairs of different genetic relatedness) was used to control for unmeasured family confounders and improve causal inference. Results: In baseline models, low resting heart rate was associated with SA (HR = 0.96; 95% CI: 0.95,0.98) and high resting heart rate with SD (HR = 1.04; 95% CI: 1.002,1.07). The association with SA remained after adjustment for all confounders (HR = 0.98). However, the association with SD did not persist after controlling for covariates. Co-relative analysis did not support causal associations. Conclusions: Our findings raise interesting etiological questions for the understanding of suicidal behaviors but do not support the usefulness of resting heart rate in suicide prediction.</p>}},
  author       = {{Lannoy, Séverine and Ohlsson, Henrik and Sundquist, Jan and Sundquist, Kristina and Edwards, Alexis C.}},
  issn         = {{0363-0234}},
  keywords     = {{death; pulse; resilience; suicide attempt}},
  language     = {{eng}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Suicide and Life-Threatening Behavior}},
  title        = {{A Swedish population-based study to evaluate the usefulness of resting heart rate in the prediction of suicidal behavior among males}},
  url          = {{http://dx.doi.org/10.1111/sltb.13077}},
  doi          = {{10.1111/sltb.13077}},
  year         = {{2024}},
}