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Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease

Breen, David P; Nombela, Cristina; Vuono, Romina; Jones, P Simon; Fisher, Kate; Burn, David J; Brooks, David J; Reddy, Akhilesh B; Rowe, James B and Barker, Roger A LU (2016) In Movement Disorders 31(7). p.6-1062
Abstract

BACKGROUND: Recent studies have suggested that melatonin-a hormone produced by the pineal gland under circadian control-contributes to PD-related sleep dysfunction. We hypothesized that degenerative changes to the neural structures controlling pineal function (especially the suprachiasmatic nuclei of the anterior hypothalamus) may be responsible for reduced melatonin output in these patients. We compared hypothalamic volumes in PD patients with matched controls and determined whether volume loss correlated with reduced melatonin output in the PD group.

METHODS: A total of 12 PD patients and 12 matched controls underwent magnetic resonance imaging to determine hypothalamic volume. In addition, PD patients underwent 24-hour blood... (More)

BACKGROUND: Recent studies have suggested that melatonin-a hormone produced by the pineal gland under circadian control-contributes to PD-related sleep dysfunction. We hypothesized that degenerative changes to the neural structures controlling pineal function (especially the suprachiasmatic nuclei of the anterior hypothalamus) may be responsible for reduced melatonin output in these patients. We compared hypothalamic volumes in PD patients with matched controls and determined whether volume loss correlated with reduced melatonin output in the PD group.

METHODS: A total of 12 PD patients and 12 matched controls underwent magnetic resonance imaging to determine hypothalamic volume. In addition, PD patients underwent 24-hour blood sampling in a controlled environment to determine serum melatonin concentrations using enzyme-linked immunosorbent assays.

RESULTS: PD patients had significantly reduced hypothalamic gray matter volume when compared with matched controls. Melatonin levels were significantly associated with hypothalamic gray matter volume and disease severity in PD patients.

CONCLUSION: Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. This provides anatomical and physiological support for an intrinsic sleep and circadian phenotype in PD. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Journal Article
in
Movement Disorders
volume
31
issue
7
pages
5 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:84977577111
ISSN
0885-3185
DOI
10.1002/mds.26592
language
English
LU publication?
no
id
abf3bcb9-13e1-47c3-92ff-f7550fc67103
date added to LUP
2016-11-23 13:15:08
date last changed
2017-10-29 04:54:22
@article{abf3bcb9-13e1-47c3-92ff-f7550fc67103,
  abstract     = {<p>BACKGROUND: Recent studies have suggested that melatonin-a hormone produced by the pineal gland under circadian control-contributes to PD-related sleep dysfunction. We hypothesized that degenerative changes to the neural structures controlling pineal function (especially the suprachiasmatic nuclei of the anterior hypothalamus) may be responsible for reduced melatonin output in these patients. We compared hypothalamic volumes in PD patients with matched controls and determined whether volume loss correlated with reduced melatonin output in the PD group.</p><p>METHODS: A total of 12 PD patients and 12 matched controls underwent magnetic resonance imaging to determine hypothalamic volume. In addition, PD patients underwent 24-hour blood sampling in a controlled environment to determine serum melatonin concentrations using enzyme-linked immunosorbent assays.</p><p>RESULTS: PD patients had significantly reduced hypothalamic gray matter volume when compared with matched controls. Melatonin levels were significantly associated with hypothalamic gray matter volume and disease severity in PD patients.</p><p>CONCLUSION: Melatonin levels are associated with hypothalamic gray matter volume loss and disease severity in PD patients. This provides anatomical and physiological support for an intrinsic sleep and circadian phenotype in PD. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.</p>},
  author       = {Breen, David P and Nombela, Cristina and Vuono, Romina and Jones, P Simon and Fisher, Kate and Burn, David J and Brooks, David J and Reddy, Akhilesh B and Rowe, James B and Barker, Roger A},
  issn         = {0885-3185},
  keyword      = {Journal Article},
  language     = {eng},
  number       = {7},
  pages        = {6--1062},
  publisher    = {John Wiley & Sons},
  series       = {Movement Disorders},
  title        = {Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease},
  url          = {http://dx.doi.org/10.1002/mds.26592},
  volume       = {31},
  year         = {2016},
}