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Learning from the past to plan for the future : A scoping review of musculoskeletal clinical research in Sweden 2010-2020

Diarbakerli, Elias ; Thoreson, Olof ; Björklund, Martin ; Dahlberg, Leif E. LU ; Englund, Martin LU orcid ; Gerdhem, Paul LU ; Kvist, Joanna ; Mohaddes, Maziar LU ; Peolsson, Anneli and Rolfson, Ola , et al. (2022) In Upsala Journal of Medical Sciences 127.
Abstract

Background: The aims of this study are to 1) determine the scope of musculoskeletal (MSK)-related clinical research in Sweden; 2) collate the amount of first-tier funding received; 3) discuss strategies and infrastructure supporting future MSK clinical trials in Sweden. Methods: A systematic scoping review protocol was applied in PubMed, Scopus, and SweCRIS databases. The articles were examined, and data were extracted in multiple stages by three blinded authors. Results: The search strategy resulted in 3,025 publications from 479 Swedish-affiliated authors. Primary health care was the basis for 14% of the publications, 84% from secondary health care, and 2% from occupational health care with a similar proportional distribution of... (More)

Background: The aims of this study are to 1) determine the scope of musculoskeletal (MSK)-related clinical research in Sweden; 2) collate the amount of first-tier funding received; 3) discuss strategies and infrastructure supporting future MSK clinical trials in Sweden. Methods: A systematic scoping review protocol was applied in PubMed, Scopus, and SweCRIS databases. The articles were examined, and data were extracted in multiple stages by three blinded authors. Results: The search strategy resulted in 3,025 publications from 479 Swedish-affiliated authors. Primary health care was the basis for 14% of the publications, 84% from secondary health care, and 2% from occupational health care with a similar proportional distribution of first-tier research grant financing. Approximately one in six publications were randomized controlled trials (RCTs), while the majority were of observational cohort design. The majority of publications in primary and occupational health care were related to pain disorders (51 and 67%, respectively), especially diagnosis, prognosis, and healthcare organizational-related interventions (34%) and rehabilitation (15%) with similar proportional distribution of first-tier research grant financing. In secondary health care, rheumatic inflammatory disorder-related publications were most prevalent (30%), most frequently concerning diagnosis, prognosis, and healthcare organizational-related interventions (20%), attracting approximately half of all first-tier funding. Publications related to degenerative joint disorders (25%), fractures (16%), and joint, tendon, and muscle injuries (13%) frequently concerned surgical and other orthopedic-related interventions (16, 6, and 8%, respectively). Pain disorder-related publications (10%) as well as bone health and osteoporosis-related publications (4%) most frequently concerned diagnosis, prognosis, and healthcare organizational-related interventions (5 and 3%, respectively). Conclusions: Swedish-affiliated MSK disorder research 2010-2020 was predominantly observational cohort rather than RCT based. There was skewed first-tier funding allocation considering prevalence/incidence and burden of disease. Use of infrastructure supporting register-based RCTs, placebo-controlled RCTs, and hybrid effectiveness-implementation studies on prevention and clinical intervention is important strategies for the future in all healthcare sectors.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
clinical research, Musculoskeletal disorders, occupational health care, primary health care, research design, research funding, secondary health care, Sweden
in
Upsala Journal of Medical Sciences
volume
127
publisher
Taylor & Francis
external identifiers
  • pmid:36337277
  • scopus:85141355356
ISSN
0300-9734
DOI
10.48101/ujms.v127.8709
language
English
LU publication?
yes
id
ac6f2244-0f54-40ec-b255-ae645566cc61
date added to LUP
2022-12-09 10:22:30
date last changed
2024-04-18 08:32:37
@article{ac6f2244-0f54-40ec-b255-ae645566cc61,
  abstract     = {{<p>Background: The aims of this study are to 1) determine the scope of musculoskeletal (MSK)-related clinical research in Sweden; 2) collate the amount of first-tier funding received; 3) discuss strategies and infrastructure supporting future MSK clinical trials in Sweden. Methods: A systematic scoping review protocol was applied in PubMed, Scopus, and SweCRIS databases. The articles were examined, and data were extracted in multiple stages by three blinded authors. Results: The search strategy resulted in 3,025 publications from 479 Swedish-affiliated authors. Primary health care was the basis for 14% of the publications, 84% from secondary health care, and 2% from occupational health care with a similar proportional distribution of first-tier research grant financing. Approximately one in six publications were randomized controlled trials (RCTs), while the majority were of observational cohort design. The majority of publications in primary and occupational health care were related to pain disorders (51 and 67%, respectively), especially diagnosis, prognosis, and healthcare organizational-related interventions (34%) and rehabilitation (15%) with similar proportional distribution of first-tier research grant financing. In secondary health care, rheumatic inflammatory disorder-related publications were most prevalent (30%), most frequently concerning diagnosis, prognosis, and healthcare organizational-related interventions (20%), attracting approximately half of all first-tier funding. Publications related to degenerative joint disorders (25%), fractures (16%), and joint, tendon, and muscle injuries (13%) frequently concerned surgical and other orthopedic-related interventions (16, 6, and 8%, respectively). Pain disorder-related publications (10%) as well as bone health and osteoporosis-related publications (4%) most frequently concerned diagnosis, prognosis, and healthcare organizational-related interventions (5 and 3%, respectively). Conclusions: Swedish-affiliated MSK disorder research 2010-2020 was predominantly observational cohort rather than RCT based. There was skewed first-tier funding allocation considering prevalence/incidence and burden of disease. Use of infrastructure supporting register-based RCTs, placebo-controlled RCTs, and hybrid effectiveness-implementation studies on prevention and clinical intervention is important strategies for the future in all healthcare sectors.</p>}},
  author       = {{Diarbakerli, Elias and Thoreson, Olof and Björklund, Martin and Dahlberg, Leif E. and Englund, Martin and Gerdhem, Paul and Kvist, Joanna and Mohaddes, Maziar and Peolsson, Anneli and Rolfson, Ola and Öberg, Birgitta and Abbott, Allan}},
  issn         = {{0300-9734}},
  keywords     = {{clinical research; Musculoskeletal disorders; occupational health care; primary health care; research design; research funding; secondary health care; Sweden}},
  language     = {{eng}},
  publisher    = {{Taylor & Francis}},
  series       = {{Upsala Journal of Medical Sciences}},
  title        = {{Learning from the past to plan for the future : A scoping review of musculoskeletal clinical research in Sweden 2010-2020}},
  url          = {{http://dx.doi.org/10.48101/ujms.v127.8709}},
  doi          = {{10.48101/ujms.v127.8709}},
  volume       = {{127}},
  year         = {{2022}},
}