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Photoacoustic Imaging of Enucleated Eyes from Patients with Uveal Melanoma can Reveal Extrascleral Growth

Dahlstrand, Ulf LU ; Merdasa, Aboma LU ; Hult, Jenny LU orcid ; Albinsson, John LU ; Cinthio, Magnus LU ; Sheikh, Rafi LU orcid and Malmsjö, Malin LU (2021) In Open Ophthalmology Journal 15(1). p.270-276
Abstract
Background:
Uveal melanoma is treated by either enucleation (removal of the eye) or local eye-sparing therapies, depending on tumor size and whether there are signs of extrascleral growth. Photoacoustic (PA) imaging is a novel imaging modality that provides high-resolution images of the molecular composition of tissues.

Objective:
In this study, the feasibility of PA imaging for uveal melanomas and detection of extrascleral growth was explored.

Methods:
Seven enucleated human eyes with uveal melanomas were examined using PA imaging. The spectral signatures of the melanomas and the layers of the normal eyewall were characterized using 59 excitation wavelengths from 680 to 970... (More)
Background:
Uveal melanoma is treated by either enucleation (removal of the eye) or local eye-sparing therapies, depending on tumor size and whether there are signs of extrascleral growth. Photoacoustic (PA) imaging is a novel imaging modality that provides high-resolution images of the molecular composition of tissues.

Objective:
In this study, the feasibility of PA imaging for uveal melanomas and detection of extrascleral growth was explored.

Methods:
Seven enucleated human eyes with uveal melanomas were examined using PA imaging. The spectral signatures of the melanomas and the layers of the normal eyewall were characterized using 59 excitation wavelengths from 680 to 970 nm.

Results:
Significant differences were seen between the spectra obtained from melanoma and the healthy eyewall. Using spectral unmixing, melanin, hemoglobin and collagen could be mapped out, showing the architecture of the tumor in relation to the eyewall. This allowed visualization of regions where the tumor extended into the extrascleral space.

Conclusion:
PA imaging appears to have the potential to aid in assessing uveal melanomas and as a diagnostic tool for the detection of extrascleral growth. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Open Ophthalmology Journal
volume
15
issue
1
pages
270 - 276
publisher
Bentham Science Publishers
external identifiers
  • scopus:85124847806
ISSN
1874-3641
DOI
10.2174/1874364102115010270
language
English
LU publication?
yes
id
acef9618-ce88-440c-ac53-bd22b18af3cd
date added to LUP
2022-01-12 00:18:03
date last changed
2022-11-08 07:16:10
@article{acef9618-ce88-440c-ac53-bd22b18af3cd,
  abstract     = {{Background:<br/>Uveal melanoma is treated by either enucleation (removal of the eye) or local eye-sparing therapies, depending on tumor size and whether there are signs of extrascleral growth. Photoacoustic (PA) imaging is a novel imaging modality that provides high-resolution images of the molecular composition of tissues.<br/><br/>Objective:<br/>In this study, the feasibility of PA imaging for uveal melanomas and detection of extrascleral growth was explored.<br/><br/>Methods:<br/>Seven enucleated human eyes with uveal melanomas were examined using PA imaging. The spectral signatures of the melanomas and the layers of the normal eyewall were characterized using 59 excitation wavelengths from 680 to 970 nm.<br/><br/>Results:<br/>Significant differences were seen between the spectra obtained from melanoma and the healthy eyewall. Using spectral unmixing, melanin, hemoglobin and collagen could be mapped out, showing the architecture of the tumor in relation to the eyewall. This allowed visualization of regions where the tumor extended into the extrascleral space.<br/><br/>Conclusion:<br/>PA imaging appears to have the potential to aid in assessing uveal melanomas and as a diagnostic tool for the detection of extrascleral growth.}},
  author       = {{Dahlstrand, Ulf and Merdasa, Aboma and Hult, Jenny and Albinsson, John and Cinthio, Magnus and Sheikh, Rafi and Malmsjö, Malin}},
  issn         = {{1874-3641}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  pages        = {{270--276}},
  publisher    = {{Bentham Science Publishers}},
  series       = {{Open Ophthalmology Journal}},
  title        = {{Photoacoustic Imaging of Enucleated Eyes from Patients with Uveal Melanoma can Reveal Extrascleral Growth}},
  url          = {{http://dx.doi.org/10.2174/1874364102115010270}},
  doi          = {{10.2174/1874364102115010270}},
  volume       = {{15}},
  year         = {{2021}},
}