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Serum osteocalcin levels do not change during rapidly induced hypercalcemia in healthy subjects

Bergenfelz, A LU and Ahrén, B LU (1992) In Hormone Research 37(1-2). p.29-32
Abstract

Since osteocalcin has been suggested to play a role in calcium homeostasis, we investigated its serum levels in 6 healthy subjects during a rapid calcium infusion. Serum levels of intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH) D3] and 1,25-dihydroxyvitamin D [1,25-(OH)2 D3] were also determined. The calcium infusion increased plasma-ionized calcium levels from 1.25 +/- 0.04 to 1.54 +/- 0.07 mmol/l at 30 min (p less than 0.05). Concomitantly, serum levels of intact PTH declined from 2.1 +/- 0.9 to 0.2 +/- 0.3 mmol/l (p less than 0.05). In contrast, serum osteocalcin levels did not change. Further, during calcium infusion, serum levels of 1,25-(OH)2 D3 decreased from 81 +/- 17 to 75 +/- 15 pmol/l (p less than 0.05) whereas... (More)

Since osteocalcin has been suggested to play a role in calcium homeostasis, we investigated its serum levels in 6 healthy subjects during a rapid calcium infusion. Serum levels of intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH) D3] and 1,25-dihydroxyvitamin D [1,25-(OH)2 D3] were also determined. The calcium infusion increased plasma-ionized calcium levels from 1.25 +/- 0.04 to 1.54 +/- 0.07 mmol/l at 30 min (p less than 0.05). Concomitantly, serum levels of intact PTH declined from 2.1 +/- 0.9 to 0.2 +/- 0.3 mmol/l (p less than 0.05). In contrast, serum osteocalcin levels did not change. Further, during calcium infusion, serum levels of 1,25-(OH)2 D3 decreased from 81 +/- 17 to 75 +/- 15 pmol/l (p less than 0.05) whereas serum levels of 25-(OH) D3 did not change. The results therefore suggest that calcium per se does not influence osteocalcin secretion.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Calcifediol, Calcitriol, Calcium, Female, Humans, Kinetics, Middle Aged, Osteocalcin, Parathyroid Hormone, Journal Article, Research Support, Non-U.S. Gov't
in
Hormone Research
volume
37
issue
1-2
pages
4 pages
publisher
Karger
external identifiers
  • scopus:0026753440
ISSN
0301-0163
DOI
10.1159/000182277
language
English
LU publication?
yes
id
ad37d2bb-6034-4201-95a6-9b3d20bf95c8
date added to LUP
2017-05-10 13:45:34
date last changed
2017-05-23 15:22:16
@article{ad37d2bb-6034-4201-95a6-9b3d20bf95c8,
  abstract     = {<p>Since osteocalcin has been suggested to play a role in calcium homeostasis, we investigated its serum levels in 6 healthy subjects during a rapid calcium infusion. Serum levels of intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH) D3] and 1,25-dihydroxyvitamin D [1,25-(OH)2 D3] were also determined. The calcium infusion increased plasma-ionized calcium levels from 1.25 +/- 0.04 to 1.54 +/- 0.07 mmol/l at 30 min (p less than 0.05). Concomitantly, serum levels of intact PTH declined from 2.1 +/- 0.9 to 0.2 +/- 0.3 mmol/l (p less than 0.05). In contrast, serum osteocalcin levels did not change. Further, during calcium infusion, serum levels of 1,25-(OH)2 D3 decreased from 81 +/- 17 to 75 +/- 15 pmol/l (p less than 0.05) whereas serum levels of 25-(OH) D3 did not change. The results therefore suggest that calcium per se does not influence osteocalcin secretion.</p>},
  author       = {Bergenfelz, A and Ahrén, B},
  issn         = {0301-0163},
  keyword      = {Calcifediol,Calcitriol,Calcium,Female,Humans,Kinetics,Middle Aged,Osteocalcin,Parathyroid Hormone,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {1-2},
  pages        = {29--32},
  publisher    = {Karger},
  series       = {Hormone Research},
  title        = {Serum osteocalcin levels do not change during rapidly induced hypercalcemia in healthy subjects},
  url          = {http://dx.doi.org/10.1159/000182277},
  volume       = {37},
  year         = {1992},
}