Serum osteocalcin levels do not change during rapidly induced hypercalcemia in healthy subjects
(1992) In Hormone Research 37(1-2). p.29-32- Abstract
Since osteocalcin has been suggested to play a role in calcium homeostasis, we investigated its serum levels in 6 healthy subjects during a rapid calcium infusion. Serum levels of intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH) D3] and 1,25-dihydroxyvitamin D [1,25-(OH)2 D3] were also determined. The calcium infusion increased plasma-ionized calcium levels from 1.25 +/- 0.04 to 1.54 +/- 0.07 mmol/l at 30 min (p less than 0.05). Concomitantly, serum levels of intact PTH declined from 2.1 +/- 0.9 to 0.2 +/- 0.3 mmol/l (p less than 0.05). In contrast, serum osteocalcin levels did not change. Further, during calcium infusion, serum levels of 1,25-(OH)2 D3 decreased from 81 +/- 17 to 75 +/- 15 pmol/l (p less than 0.05) whereas... (More)
Since osteocalcin has been suggested to play a role in calcium homeostasis, we investigated its serum levels in 6 healthy subjects during a rapid calcium infusion. Serum levels of intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH) D3] and 1,25-dihydroxyvitamin D [1,25-(OH)2 D3] were also determined. The calcium infusion increased plasma-ionized calcium levels from 1.25 +/- 0.04 to 1.54 +/- 0.07 mmol/l at 30 min (p less than 0.05). Concomitantly, serum levels of intact PTH declined from 2.1 +/- 0.9 to 0.2 +/- 0.3 mmol/l (p less than 0.05). In contrast, serum osteocalcin levels did not change. Further, during calcium infusion, serum levels of 1,25-(OH)2 D3 decreased from 81 +/- 17 to 75 +/- 15 pmol/l (p less than 0.05) whereas serum levels of 25-(OH) D3 did not change. The results therefore suggest that calcium per se does not influence osteocalcin secretion.
(Less)
- author
- Bergenfelz, A LU and Ahrén, B LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Calcifediol, Calcitriol, Calcium, Female, Humans, Kinetics, Middle Aged, Osteocalcin, Parathyroid Hormone, Journal Article, Research Support, Non-U.S. Gov't
- in
- Hormone Research
- volume
- 37
- issue
- 1-2
- pages
- 4 pages
- publisher
- Karger
- external identifiers
-
- pmid:1398473
- scopus:0026753440
- ISSN
- 0301-0163
- DOI
- 10.1159/000182277
- language
- English
- LU publication?
- yes
- id
- ad37d2bb-6034-4201-95a6-9b3d20bf95c8
- date added to LUP
- 2017-05-10 13:45:34
- date last changed
- 2024-01-13 20:34:52
@article{ad37d2bb-6034-4201-95a6-9b3d20bf95c8,
abstract = {{<p>Since osteocalcin has been suggested to play a role in calcium homeostasis, we investigated its serum levels in 6 healthy subjects during a rapid calcium infusion. Serum levels of intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25-(OH) D3] and 1,25-dihydroxyvitamin D [1,25-(OH)2 D3] were also determined. The calcium infusion increased plasma-ionized calcium levels from 1.25 +/- 0.04 to 1.54 +/- 0.07 mmol/l at 30 min (p less than 0.05). Concomitantly, serum levels of intact PTH declined from 2.1 +/- 0.9 to 0.2 +/- 0.3 mmol/l (p less than 0.05). In contrast, serum osteocalcin levels did not change. Further, during calcium infusion, serum levels of 1,25-(OH)2 D3 decreased from 81 +/- 17 to 75 +/- 15 pmol/l (p less than 0.05) whereas serum levels of 25-(OH) D3 did not change. The results therefore suggest that calcium per se does not influence osteocalcin secretion.</p>}},
author = {{Bergenfelz, A and Ahrén, B}},
issn = {{0301-0163}},
keywords = {{Calcifediol; Calcitriol; Calcium; Female; Humans; Kinetics; Middle Aged; Osteocalcin; Parathyroid Hormone; Journal Article; Research Support, Non-U.S. Gov't}},
language = {{eng}},
number = {{1-2}},
pages = {{29--32}},
publisher = {{Karger}},
series = {{Hormone Research}},
title = {{Serum osteocalcin levels do not change during rapidly induced hypercalcemia in healthy subjects}},
url = {{http://dx.doi.org/10.1159/000182277}},
doi = {{10.1159/000182277}},
volume = {{37}},
year = {{1992}},
}