Pancreatic cancer stroma : controversies and current insights
Ansari, Daniel LU ; Carvajo, Maria ; Bauden, Monika LU
and Andersson, Roland
LU
(2017)
In Scandinavian Journal of Gastroenterology
52(6-7).
p.641-646
- Abstract
Pancreatic cancer is characterized by a dense stromal response. The stroma includes a heterogeneous mass of cells, including pancreatic stellate cells, fibroblasts, immune cells and nerve cells, as well as extracellular matrix proteins, cytokines and growth factors, which interact with the tumor cells. Previous research has indicated that stromal elements contribute to tumor growth and aggressiveness. However, recent studies suggest that some elements of the stroma may actually restrain the tumor. This review focuses on the complex interactions between the stromal microenvironment and tumor cells, discussing molecular mechanisms and potential future diagnostic and therapeutic approaches by targeting the stroma.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ad696397-14a6-4dff-9188-bcac2a36241f
- author
- Ansari, Daniel
LU
; Carvajo, Maria
; Bauden, Monika
LU
and Andersson, Roland
LU
- organization
- publishing date
- 2017-07-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- desmoplasia, microenvironment, Pancreatic cancer, stroma, targeted therapy
- in
- Scandinavian Journal of Gastroenterology
- volume
- 52
- issue
- 6-7
- pages
- 641 - 646
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:28276831
- wos:000399808100005
- scopus:85018626416
- ISSN
- 0036-5521
- DOI
- 10.1080/00365521.2017.1293726
- language
- English
- LU publication?
- yes
- id
- ad696397-14a6-4dff-9188-bcac2a36241f
- date added to LUP
- 2017-06-07 15:00:48
- date last changed
- 2024-02-12 20:20:41
@article{ad696397-14a6-4dff-9188-bcac2a36241f,
abstract = {{<p>Pancreatic cancer is characterized by a dense stromal response. The stroma includes a heterogeneous mass of cells, including pancreatic stellate cells, fibroblasts, immune cells and nerve cells, as well as extracellular matrix proteins, cytokines and growth factors, which interact with the tumor cells. Previous research has indicated that stromal elements contribute to tumor growth and aggressiveness. However, recent studies suggest that some elements of the stroma may actually restrain the tumor. This review focuses on the complex interactions between the stromal microenvironment and tumor cells, discussing molecular mechanisms and potential future diagnostic and therapeutic approaches by targeting the stroma.</p>}},
author = {{Ansari, Daniel and Carvajo, Maria and Bauden, Monika and Andersson, Roland}},
issn = {{0036-5521}},
keywords = {{desmoplasia; microenvironment; Pancreatic cancer; stroma; targeted therapy}},
language = {{eng}},
month = {{07}},
number = {{6-7}},
pages = {{641--646}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Gastroenterology}},
title = {{Pancreatic cancer stroma : controversies and current insights}},
url = {{http://dx.doi.org/10.1080/00365521.2017.1293726}},
doi = {{10.1080/00365521.2017.1293726}},
volume = {{52}},
year = {{2017}},
}