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Pancreatic cancer stroma : controversies and current insights

Ansari, Daniel LU ; Carvajo, Maria; Bauden, Monika LU and Andersson, Roland LU (2017) In Scandinavian Journal of Gastroenterology 52(6-7). p.641-646
Abstract

Pancreatic cancer is characterized by a dense stromal response. The stroma includes a heterogeneous mass of cells, including pancreatic stellate cells, fibroblasts, immune cells and nerve cells, as well as extracellular matrix proteins, cytokines and growth factors, which interact with the tumor cells. Previous research has indicated that stromal elements contribute to tumor growth and aggressiveness. However, recent studies suggest that some elements of the stroma may actually restrain the tumor. This review focuses on the complex interactions between the stromal microenvironment and tumor cells, discussing molecular mechanisms and potential future diagnostic and therapeutic approaches by targeting the stroma.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
desmoplasia, microenvironment, Pancreatic cancer, stroma, targeted therapy
in
Scandinavian Journal of Gastroenterology
volume
52
issue
6-7
pages
641 - 646
publisher
Taylor & Francis
external identifiers
  • scopus:85018626416
  • wos:000399808100005
ISSN
0036-5521
DOI
10.1080/00365521.2017.1293726
language
English
LU publication?
yes
id
ad696397-14a6-4dff-9188-bcac2a36241f
date added to LUP
2017-06-07 15:00:48
date last changed
2017-09-18 11:39:01
@article{ad696397-14a6-4dff-9188-bcac2a36241f,
  abstract     = {<p>Pancreatic cancer is characterized by a dense stromal response. The stroma includes a heterogeneous mass of cells, including pancreatic stellate cells, fibroblasts, immune cells and nerve cells, as well as extracellular matrix proteins, cytokines and growth factors, which interact with the tumor cells. Previous research has indicated that stromal elements contribute to tumor growth and aggressiveness. However, recent studies suggest that some elements of the stroma may actually restrain the tumor. This review focuses on the complex interactions between the stromal microenvironment and tumor cells, discussing molecular mechanisms and potential future diagnostic and therapeutic approaches by targeting the stroma.</p>},
  author       = {Ansari, Daniel and Carvajo, Maria and Bauden, Monika and Andersson, Roland},
  issn         = {0036-5521},
  keyword      = {desmoplasia,microenvironment,Pancreatic cancer,stroma,targeted therapy},
  language     = {eng},
  month        = {07},
  number       = {6-7},
  pages        = {641--646},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Gastroenterology},
  title        = {Pancreatic cancer stroma : controversies and current insights},
  url          = {http://dx.doi.org/10.1080/00365521.2017.1293726},
  volume       = {52},
  year         = {2017},
}