Vascularization of fetal neocortical grafts implanted in brain infarcts in spontaneously hypertensive rats
(1992) In Neuroscience 51(3). p.673-682- Abstract
- The vascularization of neural grafts in ischemic brain was studied in spontaneously hypertensive rats grafted with a suspension of fetal neocortical tissue into the infarcted area five to six days after ligation of the middle cerebral artery. The brain vasculature was examined by scanning electron microscopy of corrosion vascular casts and the cortical microvasculature was stereologically quantified in light microscopy three months after the occlusion. Patent anastomoses were present between the middle cerebral artery distal to occlusion and the proximal part, as well as to the anterior and posterior cerebral arteries, in both grafted and non-grafted rats. A vascular plexus covering the infarct cavities and the grafts contained... (More)
- The vascularization of neural grafts in ischemic brain was studied in spontaneously hypertensive rats grafted with a suspension of fetal neocortical tissue into the infarcted area five to six days after ligation of the middle cerebral artery. The brain vasculature was examined by scanning electron microscopy of corrosion vascular casts and the cortical microvasculature was stereologically quantified in light microscopy three months after the occlusion. Patent anastomoses were present between the middle cerebral artery distal to occlusion and the proximal part, as well as to the anterior and posterior cerebral arteries, in both grafted and non-grafted rats. A vascular plexus covering the infarct cavities and the grafts contained leptomeningeal vessels intermingled with a thin capillary network which is not normally found on the brain surface. The graft vessels were derived from this vascular plexus. The regular pattern of arterioles and venules penetrating from the cortical surface in normal neocortex was absent in the grafts but the capillary morphology was similar in both types of tissue. The grafts had a lower capillary density than normal tissue and lacked the laminar distribution of capillaries characteristic of normal neocortex. The results demonstrate the plasticity of the vascular system where remodeling of the vascular tree after an ischemic insult provides suitable conditions for the vascularization of neocortical grafts. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106605
- author
- Grabowski, Martin LU ; Christofferson, R H ; Brundin, Patrik LU and Johansson, Barbro LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neuroscience
- volume
- 51
- issue
- 3
- pages
- 673 - 682
- publisher
- Elsevier
- external identifiers
-
- pmid:1488117
- scopus:0026447581
- ISSN
- 1873-7544
- DOI
- 10.1016/0306-4522(92)90306-M
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neurology, Lund (013027000)
- id
- ad6c6fa9-d0f1-4493-ace9-311b95702d2c (old id 1106605)
- date added to LUP
- 2016-04-01 11:41:57
- date last changed
- 2021-08-15 03:31:28
@article{ad6c6fa9-d0f1-4493-ace9-311b95702d2c,
abstract = {{The vascularization of neural grafts in ischemic brain was studied in spontaneously hypertensive rats grafted with a suspension of fetal neocortical tissue into the infarcted area five to six days after ligation of the middle cerebral artery. The brain vasculature was examined by scanning electron microscopy of corrosion vascular casts and the cortical microvasculature was stereologically quantified in light microscopy three months after the occlusion. Patent anastomoses were present between the middle cerebral artery distal to occlusion and the proximal part, as well as to the anterior and posterior cerebral arteries, in both grafted and non-grafted rats. A vascular plexus covering the infarct cavities and the grafts contained leptomeningeal vessels intermingled with a thin capillary network which is not normally found on the brain surface. The graft vessels were derived from this vascular plexus. The regular pattern of arterioles and venules penetrating from the cortical surface in normal neocortex was absent in the grafts but the capillary morphology was similar in both types of tissue. The grafts had a lower capillary density than normal tissue and lacked the laminar distribution of capillaries characteristic of normal neocortex. The results demonstrate the plasticity of the vascular system where remodeling of the vascular tree after an ischemic insult provides suitable conditions for the vascularization of neocortical grafts.}},
author = {{Grabowski, Martin and Christofferson, R H and Brundin, Patrik and Johansson, Barbro}},
issn = {{1873-7544}},
language = {{eng}},
number = {{3}},
pages = {{673--682}},
publisher = {{Elsevier}},
series = {{Neuroscience}},
title = {{Vascularization of fetal neocortical grafts implanted in brain infarcts in spontaneously hypertensive rats}},
url = {{http://dx.doi.org/10.1016/0306-4522(92)90306-M}},
doi = {{10.1016/0306-4522(92)90306-M}},
volume = {{51}},
year = {{1992}},
}