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Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations

Toft, Gunnar ; Long, Manhai ; Krüger, Tanja ; Hjelmborg, Philip S. ; Bonde, Jens Peter ; Rignell-Hydbom, Anna LU ; Tyrkiel, Ewa ; Hagmar, Lars LU ; Giwercman, Aleksander LU and Spanó, Marcello , et al. (2007) In Environmental Health Perspectives 115(SUPPL1). p.15-20
Abstract

BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in raw lipophilic serum extracts free of proteins. RESULTS: All together, 319 men from Warsaw (Poland), Greenland, Kharkiv (Ukraine), and Sweden provided semen and blood samples. No strong and consistent associations between xenobiotic activity and semen quality measures were observed in the four populations. However, when the data were combined... (More)

BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in raw lipophilic serum extracts free of proteins. RESULTS: All together, 319 men from Warsaw (Poland), Greenland, Kharkiv (Ukraine), and Sweden provided semen and blood samples. No strong and consistent associations between xenobiotic activity and semen quality measures were observed in the four populations. However, when the data were combined across populations sperm concentration increased 40% per unit increase in XER activity [95% confidence interval (CI), 1-79%] in the subgroup with XER activity below the reference level. Among subjects with XER activity above the reference level an increase of 14% (95% CI, 2-28%) was found. Furthermore, an increase of 10% motile sperm per unit increase in XER activity below reference level (95% CI, 0.2-20) was found. We are unable to exclude that the associations are chance findings. CONCLUSION: Alteration of XER, XAR, or AhR transactivity within the range found in serum from the general European and Inuit population seems not to markedly deteriorate sperm cell concentration, motility, or morphology in adult men.

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type
Contribution to journal
publication status
published
subject
keywords
Androgen receptor, Aryl hydrocarbon receptor, Calux, Endocrine disruption, Estrogen receptor, Human, Sperm
in
Environmental Health Perspectives
volume
115
issue
SUPPL1
pages
6 pages
publisher
National Institute of Environmental Health Sciences
external identifiers
  • scopus:40949160699
  • pmid:18174945
ISSN
0091-6765
DOI
10.1289/ehp.9352
language
English
LU publication?
yes
id
adb58324-3c45-459d-838e-dbdf3be2149d
date added to LUP
2019-05-21 21:21:25
date last changed
2021-02-17 03:00:44
@article{adb58324-3c45-459d-838e-dbdf3be2149d,
  abstract     = {<p>BACKGROUND: Semen quality in humans may be influenced by exposure to endocrine-disrupting compounds. OBJECTIVES: We analyzed associations between semen characteristics and serum xenoestrogen receptor (XER), xenoandrogen receptor (XAR), and aryl hydrocarbon receptor (AhR) transactivity. XER and XAR activity were measured in serum samples cleared for endogenous steroid hormones and AhR activity in raw lipophilic serum extracts free of proteins. RESULTS: All together, 319 men from Warsaw (Poland), Greenland, Kharkiv (Ukraine), and Sweden provided semen and blood samples. No strong and consistent associations between xenobiotic activity and semen quality measures were observed in the four populations. However, when the data were combined across populations sperm concentration increased 40% per unit increase in XER activity [95% confidence interval (CI), 1-79%] in the subgroup with XER activity below the reference level. Among subjects with XER activity above the reference level an increase of 14% (95% CI, 2-28%) was found. Furthermore, an increase of 10% motile sperm per unit increase in XER activity below reference level (95% CI, 0.2-20) was found. We are unable to exclude that the associations are chance findings. CONCLUSION: Alteration of XER, XAR, or AhR transactivity within the range found in serum from the general European and Inuit population seems not to markedly deteriorate sperm cell concentration, motility, or morphology in adult men.</p>},
  author       = {Toft, Gunnar and Long, Manhai and Krüger, Tanja and Hjelmborg, Philip S. and Bonde, Jens Peter and Rignell-Hydbom, Anna and Tyrkiel, Ewa and Hagmar, Lars and Giwercman, Aleksander and Spanó, Marcello and Bizzaro, Davide and Pedersen, Henning S. and Lesovoy, Vladymir and Ludwicki, Jan K. and Bonefeld-Jørgensen, Eva C.},
  issn         = {0091-6765},
  language     = {eng},
  month        = {12},
  number       = {SUPPL1},
  pages        = {15--20},
  publisher    = {National Institute of Environmental Health Sciences},
  series       = {Environmental Health Perspectives},
  title        = {Semen quality in relation to xenohormone and dioxin-like serum activity among inuits and three european populations},
  url          = {http://dx.doi.org/10.1289/ehp.9352},
  doi          = {10.1289/ehp.9352},
  volume       = {115},
  year         = {2007},
}