Proinsulin secretion during the first 3 years after diagnosis in diabetic patients with and without islet cell antibodies
(1996) In Diabetes Care 19(6). p.659-662- Abstract
OBJECTIVE - To evaluate proinsulin secretion in different types of NIDDM. RESEARCH DESIGN AND METHODS - Proinsulin and insulin were evaluated at diagnosis of diabetes and 3 years later (fasting and after stimulation with intravenous glucose and glucagon) in 10 NIDDM patients without islet cell antibodies (ICAs) at diagnosis (age 52 ± 4 years), 11 NIDDM patients with ICAs at diagnosis (age 50 ± 5 years), and 21 healthy control subjects (age 53 ± 4 years). RESULTS - At diagnosis, fasting proinsulin was higher in NIDDM patients without ICAs than in control subjects (39.6 ± 10.0 vs. 12.8 ± 1.6 pmol/l, P < 0.01). Proinsulin response to intravenous glucose decreased in NIDDM patients with ICAs (from 35.6 ± 6.2 to 13.5 ± 5.4 pmol/l, P <... (More)
OBJECTIVE - To evaluate proinsulin secretion in different types of NIDDM. RESEARCH DESIGN AND METHODS - Proinsulin and insulin were evaluated at diagnosis of diabetes and 3 years later (fasting and after stimulation with intravenous glucose and glucagon) in 10 NIDDM patients without islet cell antibodies (ICAs) at diagnosis (age 52 ± 4 years), 11 NIDDM patients with ICAs at diagnosis (age 50 ± 5 years), and 21 healthy control subjects (age 53 ± 4 years). RESULTS - At diagnosis, fasting proinsulin was higher in NIDDM patients without ICAs than in control subjects (39.6 ± 10.0 vs. 12.8 ± 1.6 pmol/l, P < 0.01). Proinsulin response to intravenous glucose decreased in NIDDM patients with ICAs (from 35.6 ± 6.2 to 13.5 ± 5.4 pmol/l, P < 0.05), but remained unchanged in those without ICAs. At 3 years after diagnosis, fasting proinsulin (10.0 ± 3.7 vs. 59.1 ± 17.0 pmol/l) and proinsulin responses to intravenous glucose (13.5 ± 5.4 vs. 103.9 ± 35.1 pmol/l) and to intravenous glucagon (7.4 ± 3.9 vs. 36.0 ± 7.7 pmol/l) were much lower (P < 0.01) in NIDDM patients with ICAs than in those without ICAs. CONCLUSIONS - After diagnosis of diabetes, proinsulin secretion decreases significantly in NIDDM patients with ICAs and remains constant in those without.
(Less)
- author
- Gottsäter, A. LU ; Owens, D. R. ; Luzio, S. and Sundkvist, G. LU
- organization
- publishing date
- 1996-06
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 19
- issue
- 6
- pages
- 4 pages
- publisher
- American Diabetes Association
- external identifiers
-
- pmid:8725869
- scopus:0029897364
- ISSN
- 0149-5992
- DOI
- 10.2337/diacare.19.6.659
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 1996 by the American Diabetes Association
- id
- adf06897-82cf-455f-bd70-753590ea36f4
- date added to LUP
- 2020-12-11 14:32:26
- date last changed
- 2024-01-03 00:53:40
@article{adf06897-82cf-455f-bd70-753590ea36f4, abstract = {{<p>OBJECTIVE - To evaluate proinsulin secretion in different types of NIDDM. RESEARCH DESIGN AND METHODS - Proinsulin and insulin were evaluated at diagnosis of diabetes and 3 years later (fasting and after stimulation with intravenous glucose and glucagon) in 10 NIDDM patients without islet cell antibodies (ICAs) at diagnosis (age 52 ± 4 years), 11 NIDDM patients with ICAs at diagnosis (age 50 ± 5 years), and 21 healthy control subjects (age 53 ± 4 years). RESULTS - At diagnosis, fasting proinsulin was higher in NIDDM patients without ICAs than in control subjects (39.6 ± 10.0 vs. 12.8 ± 1.6 pmol/l, P < 0.01). Proinsulin response to intravenous glucose decreased in NIDDM patients with ICAs (from 35.6 ± 6.2 to 13.5 ± 5.4 pmol/l, P < 0.05), but remained unchanged in those without ICAs. At 3 years after diagnosis, fasting proinsulin (10.0 ± 3.7 vs. 59.1 ± 17.0 pmol/l) and proinsulin responses to intravenous glucose (13.5 ± 5.4 vs. 103.9 ± 35.1 pmol/l) and to intravenous glucagon (7.4 ± 3.9 vs. 36.0 ± 7.7 pmol/l) were much lower (P < 0.01) in NIDDM patients with ICAs than in those without ICAs. CONCLUSIONS - After diagnosis of diabetes, proinsulin secretion decreases significantly in NIDDM patients with ICAs and remains constant in those without.</p>}}, author = {{Gottsäter, A. and Owens, D. R. and Luzio, S. and Sundkvist, G.}}, issn = {{0149-5992}}, language = {{eng}}, number = {{6}}, pages = {{659--662}}, publisher = {{American Diabetes Association}}, series = {{Diabetes Care}}, title = {{Proinsulin secretion during the first 3 years after diagnosis in diabetic patients with and without islet cell antibodies}}, url = {{http://dx.doi.org/10.2337/diacare.19.6.659}}, doi = {{10.2337/diacare.19.6.659}}, volume = {{19}}, year = {{1996}}, }