A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.
Rönn, Tina LU ; Wen, J ; Yang, Z ; Lu, B ; Du, Y ; Groop, Leif LU ; Hu, R and Ling, Charlotte LU
(2009)
In Diabetologia
Feb 25.
p.830-833
- Abstract
- AIMS/HYPOTHESIS: Recently, three groups independently reported that variation in MTNR1B, the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 diabetes, increased fasting plasma glucose and impaired insulin secretion in populations of European ancestry. In the present study, we investigated whether a single MTNR1B polymorphism was associated with type 2 diabetes in Han Chinese individuals, to elucidate whether this is a cross-populational effect. METHODS: The MTNR1B variant rs10830963 was genotyped in 1,165 type 2 diabetic patients and 1,105 normoglycaemic control individuals of southern Han Chinese ancestry who were residents of the metropolitan area of Shanghai. The risk of developing type 2 diabetes... (More)
- AIMS/HYPOTHESIS: Recently, three groups independently reported that variation in MTNR1B, the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 diabetes, increased fasting plasma glucose and impaired insulin secretion in populations of European ancestry. In the present study, we investigated whether a single MTNR1B polymorphism was associated with type 2 diabetes in Han Chinese individuals, to elucidate whether this is a cross-populational effect. METHODS: The MTNR1B variant rs10830963 was genotyped in 1,165 type 2 diabetic patients and 1,105 normoglycaemic control individuals of southern Han Chinese ancestry who were residents of the metropolitan area of Shanghai. The risk of developing type 2 diabetes was calculated using a logistic regression model adjusted for age, sex and BMI. A possible association with fasting plasma glucose was analysed in the normoglycaemic control individuals using a multiple linear regression analysis with adjustments for age, sex and BMI. RESULTS: The genetic variant rs10830963 was associated with an increased risk of type 2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p = 4 x 10(-5)) per risk allele. CONCLUSIONS/INTERPRETATION: A common variant in the MTNR1B gene is associated with an increased risk of type 2 diabetes and increased fasting plasma glucose in Han Chinese, suggesting an important role for this polymorphism in populations of different ethnic and environmental backgrounds. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1302237
- author
- Rönn, Tina
LU
; Wen, J
; Yang, Z
; Lu, B
; Du, Y
; Groop, Leif
LU
; Hu, R
and Ling, Charlotte
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetologia
- volume
- Feb 25
- pages
- 830 - 833
- publisher
- Springer
- external identifiers
-
- wos:000264884100014
- pmid:19241057
- scopus:64149094603
- pmid:19241057
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-009-1297-8
- language
- English
- LU publication?
- yes
- id
- ae07cd08-32ab-4b30-ba79-1d3002b27054 (old id 1302237)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19241057?dopt=Abstract
- date added to LUP
- 2016-04-04 08:54:59
- date last changed
- 2024-03-29 21:40:13
@article{ae07cd08-32ab-4b30-ba79-1d3002b27054,
abstract = {{AIMS/HYPOTHESIS: Recently, three groups independently reported that variation in MTNR1B, the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 diabetes, increased fasting plasma glucose and impaired insulin secretion in populations of European ancestry. In the present study, we investigated whether a single MTNR1B polymorphism was associated with type 2 diabetes in Han Chinese individuals, to elucidate whether this is a cross-populational effect. METHODS: The MTNR1B variant rs10830963 was genotyped in 1,165 type 2 diabetic patients and 1,105 normoglycaemic control individuals of southern Han Chinese ancestry who were residents of the metropolitan area of Shanghai. The risk of developing type 2 diabetes was calculated using a logistic regression model adjusted for age, sex and BMI. A possible association with fasting plasma glucose was analysed in the normoglycaemic control individuals using a multiple linear regression analysis with adjustments for age, sex and BMI. RESULTS: The genetic variant rs10830963 was associated with an increased risk of type 2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p = 4 x 10(-5)) per risk allele. CONCLUSIONS/INTERPRETATION: A common variant in the MTNR1B gene is associated with an increased risk of type 2 diabetes and increased fasting plasma glucose in Han Chinese, suggesting an important role for this polymorphism in populations of different ethnic and environmental backgrounds.}},
author = {{Rönn, Tina and Wen, J and Yang, Z and Lu, B and Du, Y and Groop, Leif and Hu, R and Ling, Charlotte}},
issn = {{1432-0428}},
language = {{eng}},
pages = {{830--833}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.}},
url = {{https://lup.lub.lu.se/search/files/5208235/1366291.pdf}},
doi = {{10.1007/s00125-009-1297-8}},
volume = {{Feb 25}},
year = {{2009}},
}