Targeting dendritic cells in pancreatic ductal adenocarcinoma
Deicher, Anton ; Andersson, Roland LU ; Tingstedt, Bobby LU ; Lindell, Gert LU ; Bauden, Monika LU
and Ansari, Daniel
LU
(2018)
In Cancer Cell International
18(1).
- Abstract
Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growing evidence for the effectiveness of vaccination with DCs pulsed with tumor antigens to initiate adaptive cytolytic immune responses via T cells. Most experience with DC-based vaccination has been gathered for MUC1 and WT1 antigens, where clinical studies in advanced pancreatic cancer have provided encouraging results. In this review, we... (More)
Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growing evidence for the effectiveness of vaccination with DCs pulsed with tumor antigens to initiate adaptive cytolytic immune responses via T cells. Most experience with DC-based vaccination has been gathered for MUC1 and WT1 antigens, where clinical studies in advanced pancreatic cancer have provided encouraging results. In this review, we highlight the role of DC in the course, prognosis and treatment of pancreatic cancer.
(Less)
- author
- Deicher, Anton
; Andersson, Roland
LU
; Tingstedt, Bobby
LU
; Lindell, Gert
LU
; Bauden, Monika
LU
and Ansari, Daniel
LU
- organization
- publishing date
- 2018-06-18
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antigen presenting cell, Dendritic cells, Immunotherapy, Pancreatic cancer, Vaccine
- in
- Cancer Cell International
- volume
- 18
- issue
- 1
- article number
- 85
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85048715485
- pmid:29946224
- ISSN
- 1475-2867
- DOI
- 10.1186/s12935-018-0585-0
- language
- English
- LU publication?
- yes
- id
- ae0b3902-363d-4911-9c73-d8b447a91dab
- date added to LUP
- 2018-06-28 13:57:37
- date last changed
- 2024-01-29 18:07:34
@article{ae0b3902-363d-4911-9c73-d8b447a91dab,
abstract = {{<p>Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growing evidence for the effectiveness of vaccination with DCs pulsed with tumor antigens to initiate adaptive cytolytic immune responses via T cells. Most experience with DC-based vaccination has been gathered for MUC1 and WT1 antigens, where clinical studies in advanced pancreatic cancer have provided encouraging results. In this review, we highlight the role of DC in the course, prognosis and treatment of pancreatic cancer.</p>}},
author = {{Deicher, Anton and Andersson, Roland and Tingstedt, Bobby and Lindell, Gert and Bauden, Monika and Ansari, Daniel}},
issn = {{1475-2867}},
keywords = {{Antigen presenting cell; Dendritic cells; Immunotherapy; Pancreatic cancer; Vaccine}},
language = {{eng}},
month = {{06}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Cancer Cell International}},
title = {{Targeting dendritic cells in pancreatic ductal adenocarcinoma}},
url = {{http://dx.doi.org/10.1186/s12935-018-0585-0}},
doi = {{10.1186/s12935-018-0585-0}},
volume = {{18}},
year = {{2018}},
}