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Targeting dendritic cells in pancreatic ductal adenocarcinoma

Deicher, Anton; Andersson, Roland LU ; Tingstedt, Bobby LU ; Lindell, Gert LU ; Bauden, Monika LU and Ansari, Daniel LU (2018) In Cancer Cell International 18(1).
Abstract

Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growing evidence for the effectiveness of vaccination with DCs pulsed with tumor antigens to initiate adaptive cytolytic immune responses via T cells. Most experience with DC-based vaccination has been gathered for MUC1 and WT1 antigens, where clinical studies in advanced pancreatic cancer have provided encouraging results. In this review, we... (More)

Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growing evidence for the effectiveness of vaccination with DCs pulsed with tumor antigens to initiate adaptive cytolytic immune responses via T cells. Most experience with DC-based vaccination has been gathered for MUC1 and WT1 antigens, where clinical studies in advanced pancreatic cancer have provided encouraging results. In this review, we highlight the role of DC in the course, prognosis and treatment of pancreatic cancer.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antigen presenting cell, Dendritic cells, Immunotherapy, Pancreatic cancer, Vaccine
in
Cancer Cell International
volume
18
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85048715485
ISSN
1475-2867
DOI
10.1186/s12935-018-0585-0
language
English
LU publication?
yes
id
ae0b3902-363d-4911-9c73-d8b447a91dab
date added to LUP
2018-06-28 13:57:37
date last changed
2019-01-06 13:58:40
@article{ae0b3902-363d-4911-9c73-d8b447a91dab,
  abstract     = {<p>Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growing evidence for the effectiveness of vaccination with DCs pulsed with tumor antigens to initiate adaptive cytolytic immune responses via T cells. Most experience with DC-based vaccination has been gathered for MUC1 and WT1 antigens, where clinical studies in advanced pancreatic cancer have provided encouraging results. In this review, we highlight the role of DC in the course, prognosis and treatment of pancreatic cancer.</p>},
  articleno    = {85},
  author       = {Deicher, Anton and Andersson, Roland and Tingstedt, Bobby and Lindell, Gert and Bauden, Monika and Ansari, Daniel},
  issn         = {1475-2867},
  keyword      = {Antigen presenting cell,Dendritic cells,Immunotherapy,Pancreatic cancer,Vaccine},
  language     = {eng},
  month        = {06},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Cancer Cell International},
  title        = {Targeting dendritic cells in pancreatic ductal adenocarcinoma},
  url          = {http://dx.doi.org/10.1186/s12935-018-0585-0},
  volume       = {18},
  year         = {2018},
}