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Reduced Body Mass Index in Parkinson's Disease: Contribution of Comorbid Depression.

Pilhatsch, Maximilian; Kroemer, Nils B; Schneider, Christine; Ebersbach, Georg; Jost, Wolfgang H; Fuchs, Gerd; Odin, Per LU ; Reifschneider, Gerd; Bauer, Michael and Reichmann, Heinz, et al. (2013) In Journal of Nervous and Mental Disease 201(1). p.76-79
Abstract
ABSTRACT: Courses of Parkinson's disease (PD) that are complicated by weight loss result in poorer overall treatment outcome and lower quality of life. To determine the contribution of depression, which has not yet been specified in the etiology of weight loss in PD, symptomatology and anamnesis from 215 outpatients diagnosed with PD were assessed using a comprehensive battery of neuropsychiatric scales. A percentage of 31 comorbid depressed patients and a comparison with a control population allowed an accurate characterization of effect sizes, sex differences, and patterns of the contribution of comorbid depression to weight loss. Our study showed that comorbid depression had a clinically relevant effect concerning reduced body mass... (More)
ABSTRACT: Courses of Parkinson's disease (PD) that are complicated by weight loss result in poorer overall treatment outcome and lower quality of life. To determine the contribution of depression, which has not yet been specified in the etiology of weight loss in PD, symptomatology and anamnesis from 215 outpatients diagnosed with PD were assessed using a comprehensive battery of neuropsychiatric scales. A percentage of 31 comorbid depressed patients and a comparison with a control population allowed an accurate characterization of effect sizes, sex differences, and patterns of the contribution of comorbid depression to weight loss. Our study showed that comorbid depression had a clinically relevant effect concerning reduced body mass index in male (0.3; Hedges' g) but not in female PD patients. Although some possible confounders are not controlled here, our results support the need of monitoring depressive symptoms in the courses of PD, particularly in male patients. (Less)
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Contribution to journal
publication status
published
subject
keywords
sex effect, weight loss, Parkinson's disease, depression
in
Journal of Nervous and Mental Disease
volume
201
issue
1
pages
76 - 79
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000313028900014
  • pmid:23274301
  • scopus:84871899044
ISSN
0022-3018
DOI
10.1097/NMD.0b013e31827ab2cc
language
English
LU publication?
yes
id
ae0e4ae0-92c9-4b1e-89ff-362f995b3750 (old id 3439161)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23274301?dopt=Abstract
date added to LUP
2013-02-04 09:28:12
date last changed
2019-02-20 06:20:20
@article{ae0e4ae0-92c9-4b1e-89ff-362f995b3750,
  abstract     = {ABSTRACT: Courses of Parkinson's disease (PD) that are complicated by weight loss result in poorer overall treatment outcome and lower quality of life. To determine the contribution of depression, which has not yet been specified in the etiology of weight loss in PD, symptomatology and anamnesis from 215 outpatients diagnosed with PD were assessed using a comprehensive battery of neuropsychiatric scales. A percentage of 31 comorbid depressed patients and a comparison with a control population allowed an accurate characterization of effect sizes, sex differences, and patterns of the contribution of comorbid depression to weight loss. Our study showed that comorbid depression had a clinically relevant effect concerning reduced body mass index in male (0.3; Hedges' g) but not in female PD patients. Although some possible confounders are not controlled here, our results support the need of monitoring depressive symptoms in the courses of PD, particularly in male patients.},
  author       = {Pilhatsch, Maximilian and Kroemer, Nils B and Schneider, Christine and Ebersbach, Georg and Jost, Wolfgang H and Fuchs, Gerd and Odin, Per and Reifschneider, Gerd and Bauer, Michael and Reichmann, Heinz and Storch, Alexander},
  issn         = {0022-3018},
  keyword      = {sex effect,weight loss,Parkinson's disease,depression},
  language     = {eng},
  number       = {1},
  pages        = {76--79},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Nervous and Mental Disease},
  title        = {Reduced Body Mass Index in Parkinson's Disease: Contribution of Comorbid Depression.},
  url          = {http://dx.doi.org/10.1097/NMD.0b013e31827ab2cc},
  volume       = {201},
  year         = {2013},
}