New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia
Lilljebjörn, Henrik LU
and Fioretos, Thoas
LU
(2017)
In Blood
130(12).
p.1395-1401
- Abstract
Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/aea8d834-1351-4c62-af1f-1bc0bd9dde23
- author
- Lilljebjörn, Henrik
LU
and Fioretos, Thoas
LU
- organization
- publishing date
- 2017-09-21
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 130
- issue
- 12
- pages
- 1395 - 1401
- publisher
- American Society of Hematology
- external identifiers
-
- scopus:85029787852
- pmid:28778863
- wos:000411319700005
- ISSN
- 0006-4971
- DOI
- 10.1182/blood-2017-05-742643
- language
- English
- LU publication?
- yes
- id
- aea8d834-1351-4c62-af1f-1bc0bd9dde23
- date added to LUP
- 2017-10-10 15:47:25
- date last changed
- 2024-03-31 16:39:51
@article{aea8d834-1351-4c62-af1f-1bc0bd9dde23,
abstract = {{<p>Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.</p>}},
author = {{Lilljebjörn, Henrik and Fioretos, Thoas}},
issn = {{0006-4971}},
language = {{eng}},
month = {{09}},
number = {{12}},
pages = {{1395--1401}},
publisher = {{American Society of Hematology}},
series = {{Blood}},
title = {{New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia}},
url = {{http://dx.doi.org/10.1182/blood-2017-05-742643}},
doi = {{10.1182/blood-2017-05-742643}},
volume = {{130}},
year = {{2017}},
}