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New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

Lilljebjörn, Henrik LU and Fioretos, Thoas LU (2017) In Blood 130(12). p.1395-1401
Abstract

Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
130
issue
12
pages
1395 - 1401
publisher
American Society of Hematology
external identifiers
  • scopus:85029787852
  • wos:000411319700005
ISSN
0006-4971
DOI
10.1182/blood-2017-05-742643
language
English
LU publication?
yes
id
aea8d834-1351-4c62-af1f-1bc0bd9dde23
date added to LUP
2017-10-10 15:47:25
date last changed
2018-04-22 04:32:48
@article{aea8d834-1351-4c62-af1f-1bc0bd9dde23,
  abstract     = {<p>Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.</p>},
  author       = {Lilljebjörn, Henrik and Fioretos, Thoas},
  issn         = {0006-4971},
  language     = {eng},
  month        = {09},
  number       = {12},
  pages        = {1395--1401},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.1182/blood-2017-05-742643},
  volume       = {130},
  year         = {2017},
}