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Outcome of PCI with Xience versus other commonly used modern drug eluting stents : A SCAAR report

Grimfjärd, Per ; Bergman, Elin ; Buccheri, Sergio ; Erlinge, David LU orcid ; Lagerqvist, Bo ; Svennblad, Bodil ; Völz, Sebastian ; Angerås, Oskar and James, Stefan (2021) In Catheterization and Cardiovascular Interventions 98(2).
Abstract

Objectives: To analyze the clinical outcome of percutaneous coronary intervention (PCI) using the Xience drug eluting stent (DES) versus other modern DES. Methods: This retrospective study based on the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) analyzed the outcome of PCI using Xience versus other commonly used modern DES, 2007 to 2017. The primary outcome measure was a combination of all-cause death, myocardial infarction (MI) and revascularisation with PCI. Angiographical outcome measures were in-stent restenosis (ISR) and stent thrombosis (ST). Results: Rates of the primary outcome measure for Xience and other DES were 31.9% and 28.2% respectively, adjusted hazard ratio (HR) 0.99 (95% CI 0.95–1.03). Crude rates of... (More)

Objectives: To analyze the clinical outcome of percutaneous coronary intervention (PCI) using the Xience drug eluting stent (DES) versus other modern DES. Methods: This retrospective study based on the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) analyzed the outcome of PCI using Xience versus other commonly used modern DES, 2007 to 2017. The primary outcome measure was a combination of all-cause death, myocardial infarction (MI) and revascularisation with PCI. Angiographical outcome measures were in-stent restenosis (ISR) and stent thrombosis (ST). Results: Rates of the primary outcome measure for Xience and other DES were 31.9% and 28.2% respectively, adjusted hazard ratio (HR) 0.99 (95% CI 0.95–1.03). Crude rates of ISR were 2.9% versus 2.1% over 4.3 and 2.9 years respectively, adjusted HR 0.93 (95% CI 0.81–1.06). Crude rates of ST were 0.9% versus 0.7%, adjusted HR 1.07 (95% CI 0.82–1.39). Results were consistent in all sensitivity analyses. Conclusions: This nationally complete, real-world study confirms that Xience is a safe and effective DES with low-event rates of ISR and ST. Compared with a control group containing a large proportion of thinner strut stents and absorbable polymers, Xience exhibits similar results in all important clinical endpoints.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
drug eluting stent, PCI, restenosis, stent thrombosis
in
Catheterization and Cardiovascular Interventions
volume
98
issue
2
publisher
Wiley-Blackwell
external identifiers
  • scopus:85102631520
  • pmid:33719169
ISSN
1522-1946
DOI
10.1002/ccd.29641
language
English
LU publication?
yes
id
aed13f84-2aa1-4783-b227-4b58d6743004
date added to LUP
2021-03-29 11:20:14
date last changed
2024-06-15 08:50:06
@article{aed13f84-2aa1-4783-b227-4b58d6743004,
  abstract     = {{<p>Objectives: To analyze the clinical outcome of percutaneous coronary intervention (PCI) using the Xience drug eluting stent (DES) versus other modern DES. Methods: This retrospective study based on the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) analyzed the outcome of PCI using Xience versus other commonly used modern DES, 2007 to 2017. The primary outcome measure was a combination of all-cause death, myocardial infarction (MI) and revascularisation with PCI. Angiographical outcome measures were in-stent restenosis (ISR) and stent thrombosis (ST). Results: Rates of the primary outcome measure for Xience and other DES were 31.9% and 28.2% respectively, adjusted hazard ratio (HR) 0.99 (95% CI 0.95–1.03). Crude rates of ISR were 2.9% versus 2.1% over 4.3 and 2.9 years respectively, adjusted HR 0.93 (95% CI 0.81–1.06). Crude rates of ST were 0.9% versus 0.7%, adjusted HR 1.07 (95% CI 0.82–1.39). Results were consistent in all sensitivity analyses. Conclusions: This nationally complete, real-world study confirms that Xience is a safe and effective DES with low-event rates of ISR and ST. Compared with a control group containing a large proportion of thinner strut stents and absorbable polymers, Xience exhibits similar results in all important clinical endpoints.</p>}},
  author       = {{Grimfjärd, Per and Bergman, Elin and Buccheri, Sergio and Erlinge, David and Lagerqvist, Bo and Svennblad, Bodil and Völz, Sebastian and Angerås, Oskar and James, Stefan}},
  issn         = {{1522-1946}},
  keywords     = {{drug eluting stent; PCI; restenosis; stent thrombosis}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Catheterization and Cardiovascular Interventions}},
  title        = {{Outcome of PCI with Xience versus other commonly used modern drug eluting stents : A SCAAR report}},
  url          = {{http://dx.doi.org/10.1002/ccd.29641}},
  doi          = {{10.1002/ccd.29641}},
  volume       = {{98}},
  year         = {{2021}},
}