Specific subsets of mesenchymal stroma cells to treat lung disorders - Finding the Holy Grail.
Rolandsson Enes, Sara LU
; Karlsson, Jenny C
LU
; Scheding, Stefan
LU
and Westergren-Thorsson, Gunilla
LU
(2014)
In Pulmonary Pharmacology & Therapeutics
29(2).
p.93-95
- Abstract
- Accumulating studies, both in animals and human clinical trials with mesenchymal stroma cells (MSC) support the hypothesis of therapeutic effects of these cells in various disorders. However, despite success in immune-mediated disorders such as Crohns' disease, lung disorders such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary disease (IPF) treated with MSC have so far not yielded a revolutionary effect on clinical symptoms. Promising data on immunomodulatory effects in COPD have kept nourishing the research into finding specific traits of MSC beneficial in disease. A heterogeneous population of injected cells might drown a potential therapeutic role of a specific group of MSC. Thus careful analysis of MSC... (More)
- Accumulating studies, both in animals and human clinical trials with mesenchymal stroma cells (MSC) support the hypothesis of therapeutic effects of these cells in various disorders. However, despite success in immune-mediated disorders such as Crohns' disease, lung disorders such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary disease (IPF) treated with MSC have so far not yielded a revolutionary effect on clinical symptoms. Promising data on immunomodulatory effects in COPD have kept nourishing the research into finding specific traits of MSC beneficial in disease. A heterogeneous population of injected cells might drown a potential therapeutic role of a specific group of MSC. Thus careful analysis of MSC regarding their molecular capabilities such as delivering specific therapeutic vesicles to the environment, or plain cytokine/chemokine fingerprinting might prove useful in augmenting therapies against lung diseases. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4691180
- author
- Rolandsson Enes, Sara
LU
; Karlsson, Jenny C
LU
; Scheding, Stefan
LU
and Westergren-Thorsson, Gunilla
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pulmonary Pharmacology & Therapeutics
- volume
- 29
- issue
- 2
- pages
- 93 - 95
- publisher
- Elsevier
- external identifiers
-
- pmid:25239767
- wos:000345949900002
- scopus:84922584613
- ISSN
- 1522-9629
- DOI
- 10.1016/j.pupt.2014.08.001
- language
- English
- LU publication?
- yes
- id
- aee9bf77-0f11-4aaf-aa9c-3eb16c3331de (old id 4691180)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25239767?dopt=Abstract
- date added to LUP
- 2016-04-01 11:14:20
- date last changed
- 2024-01-07 11:01:00
@article{aee9bf77-0f11-4aaf-aa9c-3eb16c3331de,
abstract = {{Accumulating studies, both in animals and human clinical trials with mesenchymal stroma cells (MSC) support the hypothesis of therapeutic effects of these cells in various disorders. However, despite success in immune-mediated disorders such as Crohns' disease, lung disorders such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary disease (IPF) treated with MSC have so far not yielded a revolutionary effect on clinical symptoms. Promising data on immunomodulatory effects in COPD have kept nourishing the research into finding specific traits of MSC beneficial in disease. A heterogeneous population of injected cells might drown a potential therapeutic role of a specific group of MSC. Thus careful analysis of MSC regarding their molecular capabilities such as delivering specific therapeutic vesicles to the environment, or plain cytokine/chemokine fingerprinting might prove useful in augmenting therapies against lung diseases.}},
author = {{Rolandsson Enes, Sara and Karlsson, Jenny C and Scheding, Stefan and Westergren-Thorsson, Gunilla}},
issn = {{1522-9629}},
language = {{eng}},
number = {{2}},
pages = {{93--95}},
publisher = {{Elsevier}},
series = {{Pulmonary Pharmacology & Therapeutics}},
title = {{Specific subsets of mesenchymal stroma cells to treat lung disorders - Finding the Holy Grail.}},
url = {{https://lup.lub.lu.se/search/files/2497739/5310410}},
doi = {{10.1016/j.pupt.2014.08.001}},
volume = {{29}},
year = {{2014}},
}