Association of ventricular-arterial coupling with biomarkers involved in heart failure pathophysiology - the STANISLAS cohort
(2024) In European Journal of Heart Failure- Abstract
AIMS: Impaired left ventricular-arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population-based cohort of middle-aged individuals.
METHODS AND RESULTS: In the forth visit of the STANISLAS family cohort, involving 1309 participants (mean age 48 ± 14 years; 48% male) from parent and children generations, we analysed the association of 32 HF-related proteins with non-invasively assessed VAC using pulse wave velocity (PWV)/global longitudinal strain... (More)
AIMS: Impaired left ventricular-arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population-based cohort of middle-aged individuals.
METHODS AND RESULTS: In the forth visit of the STANISLAS family cohort, involving 1309 participants (mean age 48 ± 14 years; 48% male) from parent and children generations, we analysed the association of 32 HF-related proteins with non-invasively assessed VAC using pulse wave velocity (PWV)/global longitudinal strain (GLS) and arterial elastance (E
a)/ventricular end-systolic elastance (E
es). Among the 32 tested proteins, fatty acid-binding protein adipocyte 4, interleukin-6, growth differentiation factor 15, matrix metalloproteinase (MMP)-1, and MMP-9 and adrenomedullin were positively associated with PWV/GLS whereas transforming growth factor beta receptor type 3, MMP-2 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were negatively associated. In multivariable models, only MMP-2 and NT-proBNP were significantly and inversely associated with PWV/GLS in the whole population and in the parent generation. Higher levels of NT-proBNP were also negatively associated with E
a/E
es in the whole cohort but this association did not persist in the parent subgroup.
CONCLUSION: Elevated MMP-2 and NT-proBNP levels correlate with better VAC (lower PWV/GLS), possibly indicating a compensatory cardiovascular response to regulate left ventricular pressure amidst cardiac remodelling and overload.
(Less)
- author
- organization
- publishing date
- 2024-08-27
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- European Journal of Heart Failure
- publisher
- Elsevier
- external identifiers
-
- scopus:85202146675
- pmid:39189882
- ISSN
- 1879-0844
- DOI
- 10.1002/ejhf.3411
- language
- English
- LU publication?
- yes
- additional info
- © 2024 The Author(s). European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
- id
- aff48069-faf7-4f71-ba97-63a09f8cf409
- date added to LUP
- 2024-09-04 09:21:14
- date last changed
- 2024-09-05 04:03:30
@article{aff48069-faf7-4f71-ba97-63a09f8cf409, abstract = {{<p>AIMS: Impaired left ventricular-arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population-based cohort of middle-aged individuals.</p><p>METHODS AND RESULTS: In the forth visit of the STANISLAS family cohort, involving 1309 participants (mean age 48 ± 14 years; 48% male) from parent and children generations, we analysed the association of 32 HF-related proteins with non-invasively assessed VAC using pulse wave velocity (PWV)/global longitudinal strain (GLS) and arterial elastance (E<br> a)/ventricular end-systolic elastance (E<br> es). Among the 32 tested proteins, fatty acid-binding protein adipocyte 4, interleukin-6, growth differentiation factor 15, matrix metalloproteinase (MMP)-1, and MMP-9 and adrenomedullin were positively associated with PWV/GLS whereas transforming growth factor beta receptor type 3, MMP-2 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were negatively associated. In multivariable models, only MMP-2 and NT-proBNP were significantly and inversely associated with PWV/GLS in the whole population and in the parent generation. Higher levels of NT-proBNP were also negatively associated with E<br> a/E<br> es in the whole cohort but this association did not persist in the parent subgroup.<br> </p><p>CONCLUSION: Elevated MMP-2 and NT-proBNP levels correlate with better VAC (lower PWV/GLS), possibly indicating a compensatory cardiovascular response to regulate left ventricular pressure amidst cardiac remodelling and overload.</p>}}, author = {{Holm, Hannes and Magnusson, Martin and Jujić, Amra and Lagrange, Jérémy and Bozec, Erwan and Lamiral, Zohra and Bresso, Emmanuel and Huttin, Olivier and Baudry, Guillaume and Monzo, Luca and Rossignol, Patrick and Zannad, Faiez and Girerd, Nicolas}}, issn = {{1879-0844}}, language = {{eng}}, month = {{08}}, publisher = {{Elsevier}}, series = {{European Journal of Heart Failure}}, title = {{Association of ventricular-arterial coupling with biomarkers involved in heart failure pathophysiology - the STANISLAS cohort}}, url = {{http://dx.doi.org/10.1002/ejhf.3411}}, doi = {{10.1002/ejhf.3411}}, year = {{2024}}, }