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Asymmetric reduction of ketones with enzymes from acetic acid bacteria

Adlercreutz, Patrick LU orcid (1991) In Biotechnology Letters 13(4). p.229-234
Abstract

Six strains of acetic acid bacteria were evaluated with respect to their capability to catalyze the stereoselective reduction of ketones. The cells were permeabilized before the bioconversions. The best strains were Gluconobacter oxydans DSM 50049 and Acetobacter aceti DSM 2002. Using either of these two strains it was possible to reduce all 12 ketones to (S)-alcohols with an enantiomeric excess of ≥94 %. The highest level of enzymatic activity was found in Acetobacter aceti DSM 2002.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biotechnology Letters
volume
13
issue
4
pages
6 pages
publisher
Springer
external identifiers
  • scopus:0025884262
ISSN
0141-5492
DOI
10.1007/BF01041475
language
English
LU publication?
yes
id
b02939e1-a6e7-4637-8fa1-6fee77eb89b8
date added to LUP
2019-06-22 18:45:45
date last changed
2021-01-03 04:46:23
@article{b02939e1-a6e7-4637-8fa1-6fee77eb89b8,
  abstract     = {{<p>Six strains of acetic acid bacteria were evaluated with respect to their capability to catalyze the stereoselective reduction of ketones. The cells were permeabilized before the bioconversions. The best strains were Gluconobacter oxydans DSM 50049 and Acetobacter aceti DSM 2002. Using either of these two strains it was possible to reduce all 12 ketones to (S)-alcohols with an enantiomeric excess of ≥94 %. The highest level of enzymatic activity was found in Acetobacter aceti DSM 2002.</p>}},
  author       = {{Adlercreutz, Patrick}},
  issn         = {{0141-5492}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  pages        = {{229--234}},
  publisher    = {{Springer}},
  series       = {{Biotechnology Letters}},
  title        = {{Asymmetric reduction of ketones with enzymes from acetic acid bacteria}},
  url          = {{http://dx.doi.org/10.1007/BF01041475}},
  doi          = {{10.1007/BF01041475}},
  volume       = {{13}},
  year         = {{1991}},
}