Tuning the polymer release from hydrophilic matrix tablets by mixing short and long matrix polymers
(2005) In Journal of Pharmaceutical Sciences 94(4). p.759-769- Abstract
- In this work a rotating disc method was developed for studying the dissolution process of "bimodal" polymer tablets, whose dissolution rates have been tuned by mixing low-molecular weight and high-molecular weight samples of poly(ethylene oxide) in various proportions. The tablets were prepared along different routes, by mixing the polymer fractions as powders or by mixing on a molecular level so that the effect of tablet heterogeneity could be assessed, but also by purifying the original powders so the effect of additives could be determined. When the mixed tablet was dominated by the lowmolecular weight fraction, a faster dissolution was observed for the tablet mixed at the powder level. In those cases small gel pieces were released from... (More)
- In this work a rotating disc method was developed for studying the dissolution process of "bimodal" polymer tablets, whose dissolution rates have been tuned by mixing low-molecular weight and high-molecular weight samples of poly(ethylene oxide) in various proportions. The tablets were prepared along different routes, by mixing the polymer fractions as powders or by mixing on a molecular level so that the effect of tablet heterogeneity could be assessed, but also by purifying the original powders so the effect of additives could be determined. When the mixed tablet was dominated by the lowmolecular weight fraction, a faster dissolution was observed for the tablet mixed at the powder level. In those cases small gel pieces were released from the tablet during the whole dissolution process. As long as no gel piece erosion was observed, it did not matter if the two polymer fractions were blended on the molecular level or on the powder level, the steady-state dissolution rate was the same. The presence of small amounts of additives in the nonpurified commercial samples had no significant effect on the tablet dissolution within the uncertainty of the experiment. (c) 2005 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/157434
- author
- Körner, Anna LU ; Larsson, A ; Piculell, Lennart LU and Wittgren, B
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Pharmaceutical Sciences
- volume
- 94
- issue
- 4
- pages
- 759 - 769
- publisher
- Elsevier
- external identifiers
-
- wos:000228150400006
- pmid:15723282
- scopus:17744396350
- ISSN
- 0022-3549
- DOI
- 10.1002/jps.20288
- language
- English
- LU publication?
- yes
- id
- b03e8a88-a004-4ccf-880e-b3b9a09df032 (old id 157434)
- date added to LUP
- 2016-04-01 12:12:25
- date last changed
- 2023-01-11 00:34:31
@article{b03e8a88-a004-4ccf-880e-b3b9a09df032,
abstract = {{In this work a rotating disc method was developed for studying the dissolution process of "bimodal" polymer tablets, whose dissolution rates have been tuned by mixing low-molecular weight and high-molecular weight samples of poly(ethylene oxide) in various proportions. The tablets were prepared along different routes, by mixing the polymer fractions as powders or by mixing on a molecular level so that the effect of tablet heterogeneity could be assessed, but also by purifying the original powders so the effect of additives could be determined. When the mixed tablet was dominated by the lowmolecular weight fraction, a faster dissolution was observed for the tablet mixed at the powder level. In those cases small gel pieces were released from the tablet during the whole dissolution process. As long as no gel piece erosion was observed, it did not matter if the two polymer fractions were blended on the molecular level or on the powder level, the steady-state dissolution rate was the same. The presence of small amounts of additives in the nonpurified commercial samples had no significant effect on the tablet dissolution within the uncertainty of the experiment. (c) 2005 Wiley-Liss, Inc.}},
author = {{Körner, Anna and Larsson, A and Piculell, Lennart and Wittgren, B}},
issn = {{0022-3549}},
language = {{eng}},
number = {{4}},
pages = {{759--769}},
publisher = {{Elsevier}},
series = {{Journal of Pharmaceutical Sciences}},
title = {{Tuning the polymer release from hydrophilic matrix tablets by mixing short and long matrix polymers}},
url = {{http://dx.doi.org/10.1002/jps.20288}},
doi = {{10.1002/jps.20288}},
volume = {{94}},
year = {{2005}},
}