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The efficiency of continuous regional intra-arterial infusion in the treatment of infected pancreatic necrosis

Zhou, Mengtao; Chen, Bicheng; Sun, Hongwei; Chen, Xiaolei; Yu, Zhengping; Shi, Hongqi; Yao, Jiangao; Xu, Zhengkeng; Zhang, Qiyu and Andersson, Roland LU (2013) In Pancreatology 13(3). p.212-215
Abstract
Objective: Our aim was to investigate the efficiency of continuous regional intra-arterial infusion (CRAI) with antisecretory agents and antibiotics in the treatment of infected pancreatic necrosis. Materials and methods: CRAI was used as a new clinical technique to treat acute pancreatitis patients during a 4-year period at the First Affiliated Hospital, Wenzhou Medical College, China. In this retrospective study, thirty-four patients with proven infected pancreatic necrosis were included. Twelve patients were treated with CRAL and were matched according to age, sex, APACHE II scores, Ranson scores and remote organ dysfunction, with 22 patients with IPN treated surgically. The clinical outcome following surgery and CRAI were compared.... (More)
Objective: Our aim was to investigate the efficiency of continuous regional intra-arterial infusion (CRAI) with antisecretory agents and antibiotics in the treatment of infected pancreatic necrosis. Materials and methods: CRAI was used as a new clinical technique to treat acute pancreatitis patients during a 4-year period at the First Affiliated Hospital, Wenzhou Medical College, China. In this retrospective study, thirty-four patients with proven infected pancreatic necrosis were included. Twelve patients were treated with CRAL and were matched according to age, sex, APACHE II scores, Ranson scores and remote organ dysfunction, with 22 patients with IPN treated surgically. The clinical outcome following surgery and CRAI were compared. Results: No difference was found between the two groups when comparing age, gender, APACHE II scores, Ranson scores and remote organ dysfunction (p > 0.05). The patients treated with CRAI had a lower incidence of complications (33.3% vs 72.7%), duration of hospitalization (27.1 +/- 4.7 days vs 43.0 +/- 12.0 days) and cost of hospitalization (4.09 +/- 1.64 thousand RMB vs 8.77 +/- 3.74 thousand RMB) as compared to patients treated with surgery (p < 0.05). The survival rate was significantly higher in the CRAI group as compared to the surgical group (91.7% vs 63.6%; p < 0.01). However, the two groups had similar rates of concomitant operative treatment and incidence of remote organ dysfunction (p > 0.05). Conclusions: CRAI or CRAI in combination with abscess drainage seemingly improve the clinical outcome in patients with infected pancreatic necrosis. Further confirmative prospective randomized multicenter studies are warranted prior to broad introduction of the CRAI concept. Copyright (C) 2013, IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Infected pancreatic necrosis, Continuous regional intra-arterial, infusion, Antibiotics, Treatment
in
Pancreatology
volume
13
issue
3
pages
212 - 215
publisher
Karger
external identifiers
  • wos:000320074500005
  • scopus:84884671675
ISSN
1424-3903
DOI
10.1016/j.pan.2013.02.004
language
English
LU publication?
yes
id
b07c7360-b8ca-44fb-aab4-df4fe2578c26 (old id 3930348)
date added to LUP
2013-08-01 07:36:32
date last changed
2019-01-06 03:16:44
@article{b07c7360-b8ca-44fb-aab4-df4fe2578c26,
  abstract     = {Objective: Our aim was to investigate the efficiency of continuous regional intra-arterial infusion (CRAI) with antisecretory agents and antibiotics in the treatment of infected pancreatic necrosis. Materials and methods: CRAI was used as a new clinical technique to treat acute pancreatitis patients during a 4-year period at the First Affiliated Hospital, Wenzhou Medical College, China. In this retrospective study, thirty-four patients with proven infected pancreatic necrosis were included. Twelve patients were treated with CRAL and were matched according to age, sex, APACHE II scores, Ranson scores and remote organ dysfunction, with 22 patients with IPN treated surgically. The clinical outcome following surgery and CRAI were compared. Results: No difference was found between the two groups when comparing age, gender, APACHE II scores, Ranson scores and remote organ dysfunction (p &gt; 0.05). The patients treated with CRAI had a lower incidence of complications (33.3% vs 72.7%), duration of hospitalization (27.1 +/- 4.7 days vs 43.0 +/- 12.0 days) and cost of hospitalization (4.09 +/- 1.64 thousand RMB vs 8.77 +/- 3.74 thousand RMB) as compared to patients treated with surgery (p &lt; 0.05). The survival rate was significantly higher in the CRAI group as compared to the surgical group (91.7% vs 63.6%; p &lt; 0.01). However, the two groups had similar rates of concomitant operative treatment and incidence of remote organ dysfunction (p &gt; 0.05). Conclusions: CRAI or CRAI in combination with abscess drainage seemingly improve the clinical outcome in patients with infected pancreatic necrosis. Further confirmative prospective randomized multicenter studies are warranted prior to broad introduction of the CRAI concept. Copyright (C) 2013, IAP and EPC. Published by Elsevier India, a division of Reed Elsevier India Pvt. Ltd. All rights reserved.},
  author       = {Zhou, Mengtao and Chen, Bicheng and Sun, Hongwei and Chen, Xiaolei and Yu, Zhengping and Shi, Hongqi and Yao, Jiangao and Xu, Zhengkeng and Zhang, Qiyu and Andersson, Roland},
  issn         = {1424-3903},
  keyword      = {Infected pancreatic necrosis,Continuous regional intra-arterial,infusion,Antibiotics,Treatment},
  language     = {eng},
  number       = {3},
  pages        = {212--215},
  publisher    = {Karger},
  series       = {Pancreatology},
  title        = {The efficiency of continuous regional intra-arterial infusion in the treatment of infected pancreatic necrosis},
  url          = {http://dx.doi.org/10.1016/j.pan.2013.02.004},
  volume       = {13},
  year         = {2013},
}