Are collagenous and lymphocytic colitis different aspects of the same disease?
Vigren, Lina LU ; Olesen, Martin ; Benoni, Cecilia LU and Sjöberg, Klas LU
(2012)
In Scandinavian Journal of Gastroenterology
47(12).
p.1448-1453
- Abstract
- Objective. Collagenous colitis (CC) and lymphocytic colitis (LC) are two subtypes of microscopic colitis (MC). Even though they most often are described as different entities they share many clinical and histological features. The aim of this study was to investigate the occurrence of conversion between CC and LC in a larger cohort of patients. Materials and methods. All 664 patients in our Pathology register with a diagnosis of CC and LC were scrutinized and those where additional endoscopies had been carried out were included, and their biopsies were re-examined. Results. Sixty-five patients (55 women, 10 men, median age 58 years; range 29-86) fulfilled our criteria for inclusion. The primary diagnosis was CC in 47 patients (39 women, 8... (More)
- Objective. Collagenous colitis (CC) and lymphocytic colitis (LC) are two subtypes of microscopic colitis (MC). Even though they most often are described as different entities they share many clinical and histological features. The aim of this study was to investigate the occurrence of conversion between CC and LC in a larger cohort of patients. Materials and methods. All 664 patients in our Pathology register with a diagnosis of CC and LC were scrutinized and those where additional endoscopies had been carried out were included, and their biopsies were re-examined. Results. Sixty-five patients (55 women, 10 men, median age 58 years; range 29-86) fulfilled our criteria for inclusion. The primary diagnosis was CC in 47 patients (39 women, 8 men, median age 58 years; range 29-86) and LC in 18 patients (16 women, 2 men, median age 58 years; range 33-74). Conversion occurred in nine of the 65 patients (14%, all women, median age 59 years; range 41-72), three from CC to LC and six from LC to CC. Conclusion. This study has found that patients can show histological features consistent with both CC and LC over time. These patients could represent a subgroup with a true conversion between two separate entities. Alternatively, MC could be a spectral disease where the varying histological features are manifestations of the natural fluctuation. A third possibility could be that the histological changes reflect different manifestations during the disease course and consequently, the diagnostic criteria could be too vague. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3366291
- author
- Vigren, Lina
LU
; Olesen, Martin
; Benoni, Cecilia
LU
and Sjöberg, Klas
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bile acid diarrhea, coeliac disease, collagenous colitis, conversion, follow-up, lymphocytic colitis, microscopic colitis
- in
- Scandinavian Journal of Gastroenterology
- volume
- 47
- issue
- 12
- pages
- 1448 - 1453
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000312427800006
- scopus:84869995780
- pmid:23016916
- ISSN
- 1502-7708
- DOI
- 10.3109/00365521.2012.729085
- language
- English
- LU publication?
- yes
- id
- b085faf9-38aa-4b6a-a72d-f5d039a45cb2 (old id 3366291)
- date added to LUP
- 2016-04-01 14:23:28
- date last changed
- 2023-04-18 20:15:50
@article{b085faf9-38aa-4b6a-a72d-f5d039a45cb2,
abstract = {{Objective. Collagenous colitis (CC) and lymphocytic colitis (LC) are two subtypes of microscopic colitis (MC). Even though they most often are described as different entities they share many clinical and histological features. The aim of this study was to investigate the occurrence of conversion between CC and LC in a larger cohort of patients. Materials and methods. All 664 patients in our Pathology register with a diagnosis of CC and LC were scrutinized and those where additional endoscopies had been carried out were included, and their biopsies were re-examined. Results. Sixty-five patients (55 women, 10 men, median age 58 years; range 29-86) fulfilled our criteria for inclusion. The primary diagnosis was CC in 47 patients (39 women, 8 men, median age 58 years; range 29-86) and LC in 18 patients (16 women, 2 men, median age 58 years; range 33-74). Conversion occurred in nine of the 65 patients (14%, all women, median age 59 years; range 41-72), three from CC to LC and six from LC to CC. Conclusion. This study has found that patients can show histological features consistent with both CC and LC over time. These patients could represent a subgroup with a true conversion between two separate entities. Alternatively, MC could be a spectral disease where the varying histological features are manifestations of the natural fluctuation. A third possibility could be that the histological changes reflect different manifestations during the disease course and consequently, the diagnostic criteria could be too vague.}},
author = {{Vigren, Lina and Olesen, Martin and Benoni, Cecilia and Sjöberg, Klas}},
issn = {{1502-7708}},
keywords = {{bile acid diarrhea; coeliac disease; collagenous colitis; conversion; follow-up; lymphocytic colitis; microscopic colitis}},
language = {{eng}},
number = {{12}},
pages = {{1448--1453}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Gastroenterology}},
title = {{Are collagenous and lymphocytic colitis different aspects of the same disease?}},
url = {{https://lup.lub.lu.se/search/files/3948108/4180038.pdf}},
doi = {{10.3109/00365521.2012.729085}},
volume = {{47}},
year = {{2012}},
}