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Angiogenesis inhibitor TNP-470 augments the effect of repeated arterial ischemia on growth but does not affect take in a rat liver tumor model

Möller, Fáll Helgi ; Ivarsson, Kjell LU ; Roos, Gunnel LU ; Radnell, Monica ; Persson, B. O. ; Tranberg, Karl Göran LU and Stenram, Unne LU (1997) In Anticancer research 17(4 A). p.2401-2406
Abstract

Transient hepatic arterial occlusion causes necrosis in solid hepatic tumors in the rat, but regrowth of tumor cells and capillaries takes place from the tumor periphery. It was therefore considered of interest to combine this treatment with the angiogenesis inhibitor TNP-470 (therapeutic model). Wistar rats with a dimethylhydrazine-induced adenocarcinoma implanted into the liver received one of the following treatments: TNP-470 + transient hepatic ischemia, transient hepatic ischemia alone, TNP-470 alone or sham solution alone. Rats were sacrificed one week after the start of treatment. In addition, we investigated if TNP-470 decreases the risk of tumor take in the liver after intraportal injection of viable tumor cells (adjuvant... (More)

Transient hepatic arterial occlusion causes necrosis in solid hepatic tumors in the rat, but regrowth of tumor cells and capillaries takes place from the tumor periphery. It was therefore considered of interest to combine this treatment with the angiogenesis inhibitor TNP-470 (therapeutic model). Wistar rats with a dimethylhydrazine-induced adenocarcinoma implanted into the liver received one of the following treatments: TNP-470 + transient hepatic ischemia, transient hepatic ischemia alone, TNP-470 alone or sham solution alone. Rats were sacrificed one week after the start of treatment. In addition, we investigated if TNP-470 decreases the risk of tumor take in the liver after intraportal injection of viable tumor cells (adjuvant study). Transient hepatic ischemia combined with TNP-470 gave a smaller increase in tumor volume than transient hepatic ischemia (p < 0.01), TNP-470 (p < 0.001) alone or no treatment (p < 0.001). Transient hepatic ischemia or TNP-470 caused a significant suppression of tumor growth when compared to controls (p < 0.01 in both cases). In the adjuvant study, TNP-470 caused retardation of tumor growth (p < 0.01 as compared to controls) but did not affect tumor number. It is concluded that TNP-470 suppressed tumor growth, both alone and in combination with transient hepatic ischemia, but did not affect take of tumor.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dearterialization, Hepatic ischemia, Rat liver tumor, TNP-470
in
Anticancer research
volume
17
issue
4 A
pages
6 pages
publisher
International Institute of Cancer Research
external identifiers
  • pmid:9252654
  • scopus:1842411967
ISSN
0250-7005
language
English
LU publication?
yes
id
b08e90bd-b77f-4ea6-91c4-56e77fc1bdba
date added to LUP
2019-06-15 16:57:20
date last changed
2024-10-02 04:52:41
@article{b08e90bd-b77f-4ea6-91c4-56e77fc1bdba,
  abstract     = {{<p>Transient hepatic arterial occlusion causes necrosis in solid hepatic tumors in the rat, but regrowth of tumor cells and capillaries takes place from the tumor periphery. It was therefore considered of interest to combine this treatment with the angiogenesis inhibitor TNP-470 (therapeutic model). Wistar rats with a dimethylhydrazine-induced adenocarcinoma implanted into the liver received one of the following treatments: TNP-470 + transient hepatic ischemia, transient hepatic ischemia alone, TNP-470 alone or sham solution alone. Rats were sacrificed one week after the start of treatment. In addition, we investigated if TNP-470 decreases the risk of tumor take in the liver after intraportal injection of viable tumor cells (adjuvant study). Transient hepatic ischemia combined with TNP-470 gave a smaller increase in tumor volume than transient hepatic ischemia (p &lt; 0.01), TNP-470 (p &lt; 0.001) alone or no treatment (p &lt; 0.001). Transient hepatic ischemia or TNP-470 caused a significant suppression of tumor growth when compared to controls (p &lt; 0.01 in both cases). In the adjuvant study, TNP-470 caused retardation of tumor growth (p &lt; 0.01 as compared to controls) but did not affect tumor number. It is concluded that TNP-470 suppressed tumor growth, both alone and in combination with transient hepatic ischemia, but did not affect take of tumor.</p>}},
  author       = {{Möller, Fáll Helgi and Ivarsson, Kjell and Roos, Gunnel and Radnell, Monica and Persson, B. O. and Tranberg, Karl Göran and Stenram, Unne}},
  issn         = {{0250-7005}},
  keywords     = {{Dearterialization; Hepatic ischemia; Rat liver tumor; TNP-470}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{4 A}},
  pages        = {{2401--2406}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{Angiogenesis inhibitor TNP-470 augments the effect of repeated arterial ischemia on growth but does not affect take in a rat liver tumor model}},
  volume       = {{17}},
  year         = {{1997}},
}