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Within-session reproducibility of forced oscillometry

Wollmer, Per LU ; Tufvesson, Ellen LU ; Wennersten, André LU ; Malmqvist, Ulf LU ; Engström, Gunnar LU ; Olsson, Henric K LU ; Zaigham, Suneela LU ; Frantz, Sophia LU and Nihlén, Ulf LU (2021) In Clinical Physiology and Functional Imaging 41(5). p.401-407
Abstract

BACKGROUND: The forced oscillation technique (FOT) provides detailed information about the mechanics of the respiratory system, while requiring minimal co-operation by the patient. FOT may be abnormal in subjects with normal spirometry and appears to be more closely related to airway symptoms. It is, therefore, attractive in epidemiological studies, where a large number of different examinations are made in each subjects in a short period of time. Current technical standards recommend the mean of three consecutive measurements to be used, but there is limited information regarding within-session variability of FOT measurements.

OBJECTIVE: The purpose of this study was to examine the within-session variability in FOT measurements... (More)

BACKGROUND: The forced oscillation technique (FOT) provides detailed information about the mechanics of the respiratory system, while requiring minimal co-operation by the patient. FOT may be abnormal in subjects with normal spirometry and appears to be more closely related to airway symptoms. It is, therefore, attractive in epidemiological studies, where a large number of different examinations are made in each subjects in a short period of time. Current technical standards recommend the mean of three consecutive measurements to be used, but there is limited information regarding within-session variability of FOT measurements.

OBJECTIVE: The purpose of this study was to examine the within-session variability in FOT measurements in a large, population-based sample.

METHODS: We performed three consecutive FOT measurements in 700 subjects using the impulse oscillometry system. The first measurement was compared to the mean of three measurements for resistance at 5 and 20 Hz (R5 and R20, respectively), R5-R20, reactance at 5 Hz (X5) and resonant frequency (fres ).

RESULTS: The differences between the first and the mean of three measurements (median, interquartile range) were minimal, for example 0.002, -0.008 to 0.014 kPa L-1 s for R5 and -0.001, -0.008 to 0.005 kPa L-1 s for X5. Findings were numerically similar for men and women as well as for subjects with and without airflow obstruction at spirometry.

CONCLUSIONS: We conclude that, whereas in clinical situations, three FOT measurements are to be preferred, a single measurement may suffice in epidemiological studies.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging
volume
41
issue
5
pages
401 - 407
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85106227422
  • pmid:33914403
ISSN
1475-0961
DOI
10.1111/cpf.12706
language
English
LU publication?
yes
id
b0b22115-00b7-44fe-92e4-1ab8d241a386
date added to LUP
2021-06-16 16:04:11
date last changed
2024-04-20 07:32:17
@article{b0b22115-00b7-44fe-92e4-1ab8d241a386,
  abstract     = {{<p>BACKGROUND: The forced oscillation technique (FOT) provides detailed information about the mechanics of the respiratory system, while requiring minimal co-operation by the patient. FOT may be abnormal in subjects with normal spirometry and appears to be more closely related to airway symptoms. It is, therefore, attractive in epidemiological studies, where a large number of different examinations are made in each subjects in a short period of time. Current technical standards recommend the mean of three consecutive measurements to be used, but there is limited information regarding within-session variability of FOT measurements.</p><p>OBJECTIVE: The purpose of this study was to examine the within-session variability in FOT measurements in a large, population-based sample.</p><p>METHODS: We performed three consecutive FOT measurements in 700 subjects using the impulse oscillometry system. The first measurement was compared to the mean of three measurements for resistance at 5 and 20 Hz (R5 and R20, respectively), R5-R20, reactance at 5 Hz (X5) and resonant frequency (fres ).</p><p>RESULTS: The differences between the first and the mean of three measurements (median, interquartile range) were minimal, for example 0.002, -0.008 to 0.014 kPa L-1 s for R5 and -0.001, -0.008 to 0.005 kPa L-1 s for X5. Findings were numerically similar for men and women as well as for subjects with and without airflow obstruction at spirometry.</p><p>CONCLUSIONS: We conclude that, whereas in clinical situations, three FOT measurements are to be preferred, a single measurement may suffice in epidemiological studies.</p>}},
  author       = {{Wollmer, Per and Tufvesson, Ellen and Wennersten, André and Malmqvist, Ulf and Engström, Gunnar and Olsson, Henric K and Zaigham, Suneela and Frantz, Sophia and Nihlén, Ulf}},
  issn         = {{1475-0961}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{5}},
  pages        = {{401--407}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Clinical Physiology and Functional Imaging}},
  title        = {{Within-session reproducibility of forced oscillometry}},
  url          = {{http://dx.doi.org/10.1111/cpf.12706}},
  doi          = {{10.1111/cpf.12706}},
  volume       = {{41}},
  year         = {{2021}},
}