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Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells.

Karnevi, Emelie LU ; Said Hilmersson, Katarzyna LU ; Andersson, Roland LU and Rosendahl, Ann LU (2013) In BMC Cancer 13(May,10).
Abstract
Epidemiological studies have shown direct associations between type 2 diabetes and obesity, both conditions associated with hyperglycaemia and hyperinsulinemia, and the risk of pancreatic cancer. Up to 80% of pancreatic cancer patients present with either new-onset type 2 diabetes or impaired glucose tolerance at the time of diagnosis. Recent population studies indicate that the incidence of pancreatic cancer is reduced among diabetics taking metformin. In this study, the effects of exposure of pancreatic cancer cells to high glucose levels on their growth and response to metformin were investigated.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Cancer
volume
13
issue
May,10
publisher
BioMed Central
external identifiers
  • wos:000319268900001
  • pmid:23663483
  • scopus:84877251996
ISSN
1471-2407
DOI
10.1186/1471-2407-13-235
language
English
LU publication?
yes
id
b11ef0ac-6b4a-46a1-a2af-496a50fe5d9c (old id 3804634)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23663483?dopt=Abstract
date added to LUP
2013-06-06 16:41:10
date last changed
2019-02-17 03:51:49
@article{b11ef0ac-6b4a-46a1-a2af-496a50fe5d9c,
  abstract     = {Epidemiological studies have shown direct associations between type 2 diabetes and obesity, both conditions associated with hyperglycaemia and hyperinsulinemia, and the risk of pancreatic cancer. Up to 80% of pancreatic cancer patients present with either new-onset type 2 diabetes or impaired glucose tolerance at the time of diagnosis. Recent population studies indicate that the incidence of pancreatic cancer is reduced among diabetics taking metformin. In this study, the effects of exposure of pancreatic cancer cells to high glucose levels on their growth and response to metformin were investigated.},
  articleno    = {235},
  author       = {Karnevi, Emelie and Said Hilmersson, Katarzyna and Andersson, Roland and Rosendahl, Ann},
  issn         = {1471-2407},
  language     = {eng},
  number       = {May,10},
  publisher    = {BioMed Central},
  series       = {BMC Cancer},
  title        = {Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells.},
  url          = {http://dx.doi.org/10.1186/1471-2407-13-235},
  volume       = {13},
  year         = {2013},
}