Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells.
(2013) In BMC Cancer 13(May,10).- Abstract
- Epidemiological studies have shown direct associations between type 2 diabetes and obesity, both conditions associated with hyperglycaemia and hyperinsulinemia, and the risk of pancreatic cancer. Up to 80% of pancreatic cancer patients present with either new-onset type 2 diabetes or impaired glucose tolerance at the time of diagnosis. Recent population studies indicate that the incidence of pancreatic cancer is reduced among diabetics taking metformin. In this study, the effects of exposure of pancreatic cancer cells to high glucose levels on their growth and response to metformin were investigated.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3804634
- author
- Karnevi, Emelie LU ; Said Hilmersson, Katarzyna LU ; Andersson, Roland LU and Rosendahl, Ann LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Cancer
- volume
- 13
- issue
- May,10
- article number
- 235
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000319268900001
- pmid:23663483
- scopus:84877251996
- pmid:23663483
- ISSN
- 1471-2407
- DOI
- 10.1186/1471-2407-13-235
- language
- English
- LU publication?
- yes
- id
- b11ef0ac-6b4a-46a1-a2af-496a50fe5d9c (old id 3804634)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23663483?dopt=Abstract
- date added to LUP
- 2016-04-01 13:22:24
- date last changed
- 2022-03-21 18:13:05
@article{b11ef0ac-6b4a-46a1-a2af-496a50fe5d9c, abstract = {{Epidemiological studies have shown direct associations between type 2 diabetes and obesity, both conditions associated with hyperglycaemia and hyperinsulinemia, and the risk of pancreatic cancer. Up to 80% of pancreatic cancer patients present with either new-onset type 2 diabetes or impaired glucose tolerance at the time of diagnosis. Recent population studies indicate that the incidence of pancreatic cancer is reduced among diabetics taking metformin. In this study, the effects of exposure of pancreatic cancer cells to high glucose levels on their growth and response to metformin were investigated.}}, author = {{Karnevi, Emelie and Said Hilmersson, Katarzyna and Andersson, Roland and Rosendahl, Ann}}, issn = {{1471-2407}}, language = {{eng}}, number = {{May,10}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Cancer}}, title = {{Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells.}}, url = {{http://dx.doi.org/10.1186/1471-2407-13-235}}, doi = {{10.1186/1471-2407-13-235}}, volume = {{13}}, year = {{2013}}, }